A5031187847- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Graphene and Nanomaterials Applications
- Fish biology, ecology, and behavior
- Skin Protection and Aging
- Inhalation and Respiratory Drug Delivery
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Organoselenium and organotellurium chemistry
- Electrochemical Analysis and Applications
- Multicomponent Synthesis of Heterocycles
- Analytical chemistry methods development
- Neonatal Respiratory Health Research
- Barrier Structure and Function Studies
- Extracellular vesicles in disease
- Probiotics and Fermented Foods
- Microfluidic and Bio-sensing Technologies
- Carbon and Quantum Dots Applications
Panjab University
2021-2025
Delhi Technological University
2013-2016
University of Delhi
2015
In light of growing global challenge posed by antimicrobial resistance, it is very important to explore alternatives that can target pathogenic microorganisms. One such strategy involves the use peptides (AMPs) and Stigmurin one AMP present in Brazilian scorpion Tityus stigmurus which possesses antimicrobial, antiproliferative antiparasitic activity. The study commenced with successful synthesis characterization its analogues, designated S1 S2. Studies on analogues have demonstrated exhibit...
Bis(3-amino-1-hydroxybenzyl)diselenide containing two ortho groups was synthesized from 7-nitro-3H-2,1-benzoxaselenole and in situ generated sodium benzene tellurolate (PhTeNa). One-pot synthesis of 1,3-benzoselenazoles achieved bis(3-amino-1-hydroxybenzyl)diselenide aryl aldehydes using acetic acid as a catalyst. The X-ray crystal structure chloro-substituted benzoselenazole revealed planar with T-shaped geometry around the Se atom. Both natural bond orbital atoms molecules calculations...
We report, for the first time, bio-inspired synthesis of a bioactive glass-ceramic with superior textural properties in atmospheric conditions using CT-DNA as template. The phase composition, structure, morphology, and glass sample were evaluated various analytical techniques before after vitro tests. BET surface area analysis obtained reveals that it possesses high range (micro- to meso-) pore sizes. TEM indicates amorphous consists spherical particles, whereas crystalline is found have...
Respiratory diseases (RD) are a group of common ailments with rapidly increasing global prevalence, posing significant threat to humanity, especially the elderly population, and imposing substantial burden on society economy. RD represents an unmet medical need that requires development viable pharmacotherapies. While various promising strategies have been devised advance potential treatments for RD, their implementation has hindered by difficulties in drug delivery, particularly critically...
Proteins are essential building blocks in humans that have garnered huge attention from researchers worldwide due to their numerous therapeutic applications. To date, different computational tools been developed extract pre-existing information on these biological molecules, but most of suffer limitations such as non-user friendly interface, redundancy data, etc. overcome limitations, a user-friendly the Peptide Utility (PU) webserver (https://chain-searching.herokuapp.com/) has for...
Abstract The current work involves the use of dehydroacetic acid based chalcone derivatives for synthesis spirooxindole grafted pyrrolidine moieties. All synthesized compounds have been characterized using spectroscopic techniques such as NMR ( 1 H-NMR and 13 C-NMR), IR, mass elemental analysis. Molecular mechanics studies were performed to comprehend regioselectivity in product formation. docking was with few bacterial proteins Bacillus subtilis Pseudomonas aeruginosa responsible biofilm...
Breast cancer is one of the leading causes death among women globally, making its diagnosis and treatment challenging. The use nanotechnology for an emerging area research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes observed using SEM, while TEM structural integrity MWCNTs after functionalization. Particle...
Pharmaceutical development of cancer therapeutics is a dynamic area research. Even after decades intensive work, continues to be dreadful disease with an ever-increasing global incidence. The progress nanotechnology in research has overcome inherent limitations conventional chemotherapy and fulfilled the need for target-specific drug carriers. Nanotechnology uses altered patho-physiological microenvironment malignant cells offers various advantages like improved solubility, reduced toxicity,...
The present study is focused on a simple execution in the applicability of non-toxic lower generation poly amidoamine (PAMAM) dendrimers as effective nano-vectors targeted gene delivery to skin. So far first three (G1, G2 and G3) PAMAM have been overlooked nucleic acid therapeutics. In this study, we carried out systematic biophysical analysis analyze their ability for plasmid DNA (pDNA) condensation subsequent release by ethidium bromide assay optimize dendrimer charge ratio pDNA release....
A direct insight into the 14-mer oligonucleotide and dendrimer interactions using fluorescence FRET techniques is focus of this study.