A5091152739- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Ocular Surface and Contact Lens
- Herpesvirus Infections and Treatments
- Surfactants and Colloidal Systems
- Pain Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Toxin Mechanisms and Immunotoxins
- Sirtuins and Resveratrol in Medicine
- Characterization and Applications of Magnetic Nanoparticles
- Dental Implant Techniques and Outcomes
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Contact Dermatitis and Allergies
- Wound Healing and Treatments
- Pharmacology and Obesity Treatment
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
Auburn University
2018-2024
Quality Research
2024
United States Food and Drug Administration
2024
Abstract Cyclosporine A (CsA) is a cyclic peptide immunosuppressant drug that beneficial in the treatment of various ocular diseases. However, its bioavailability posterior eye limited due to poor aqueous solubility. Conventional CsA formulations such as solution or emulsion permeate poorly across static and dynamic barriers eye. Dissolvable microneedle (MN)-based patches can be used overcome barrier properties and, thus, enhance CsA-loaded dissolvable MN were fabricated using...
Daunorubicin (DNR) was delivered using a pH-sensitive liposomal system in B16-BL6 melanoma cell lines for enhanced cytotoxic effects. DNR encapsulated within liposomes and CL as component of the lipid bilayer. PEGylated liposomes, containing CL, were prepared molar ratio 40:30:5:17:8 DOPE/cholesterol/DSPE-mPEG (2000)/CL/SA film hydration method loaded with (drug: 1:5). The exhibited high drug encapsulation efficiency (>90%), small size (~94 nm), narrow distribution (polydispersity index...
Despite rapid progress in tissue engineering, the repair and regeneration of bone defects remains challenging, especially for non-homogenous complicated defects. We have developed characterized biodegradable drug-eluting scaffolds utilizing direct powder extrusion-based three-dimensional (3D) printing techniques. The PLGA were fabricated using poly (lactic-co-glycolic acid) (PLGA) with inherent viscosities 0.2 dl/g 0.4 ketoprofen. effect parameters such as infill, geometry, wall thickness...
Purpose: Difluprednate ophthalmic emulsion (Durezol®) is currently used for the treatment of anterior uveitis; however, recent studies have shown that difluprednate can treat posterior eye conditions. Topical formulations limit amount drug capable permeating to segment due permeation barriers, lacrimation, and lymphatic clearance. Methods: Resomer®-based microneedle patches were fabricated using poly(acrylic acid) (PAA) rapidly dissolvable backing. The analyzed uniformity sharpness scanning...
Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing inflammation and acute pain. Although available oral parenteral formulations such as capsule, tablet, suspension, solution, frequent administration is necessary to maintain therapeutic efficacy, which can increase adverse effects patient non-compliance. To address these issues, several sustained drug delivery strategies oral, transdermal, transmucosal, injectable, implantable systems have been...
This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl Boldine (DAB) and evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro. Using pseudo-ternary phase diagram, the optimal region was identified, particle size, viscosity, pH, vitro release characteristics were determined. Permeation studies performed on excised human skin using Franz diffusion assembly. The formulations B16BL6 lines evaluated by MTT...
A simple, rapid and accurate stability-indicating HPLC assay was developed for the determination of acyclovir lidocaine in topical formulations. Chromatographic separation achieved using a reversed-phase C18 column gradient mobile phase (20 mm ammonium acetate pH 3.5 water acetonitrile). The degradation products samples were analyzed by ultra performance liquid chromatography-time flight mass spectrometry. method successfully resolved analytes from impurities formulation. Furthermore,...
Hispolon, a phenolic pigment isolated from the mushroom species Phellinus linteus, has been investigated for anti-inflammatory, antioxidant, and anticancer properties; however, low solubility poor bioavailability have limited its potential clinical translation. In this study, inclusion complex of hispolon with Sulfobutylether-β-cyclodextrin (SBEβCD) was characterized, Hispolon-SBEβCD Complex (HSC) included within sterically stabilized liposomes (SL) to further investigate activity against...
A surgically implantable device is an inevitable treatment option for millions of people worldwide suffering from diseases arising orthopedic injuries. global paradigm shift currently underway to tailor and personalize replacement or reconstructive joints. Additive manufacturing (AM) has provided dynamic outflow the customized fabrication implants by enabling need-based design surface modification possibilities. Surgical grade 316L Stainless Steel (316L SS) promising with its cost, strength,...
To develop a topical sildenafil hydrogel and evaluate its effect on wound healing in dogs.6 purpose-bred, sexually intact, adult Beagles.Hydrogels containing citrate, N-methyl-2-pyrrolidone, propylene glycol, poloxamer 407 were developed. Four excision wounds created along the dorsum of dogs. Each was treated for 21 days with nonadherent bandage (C) or 0% (G), 5% (5S), 10% (10S) sildenafil. Daily changes imaging performed. Biopsy specimens collected 5 times.Hydrogels homogenous at room...
Aim: Additively manufactured (3D printed), stainless steel implants were coated with dexamethasone using gelatin, chondroitin sulfate for use in bone graft surgeries. Materials & methods: The drug and polymers deposited on the a rough surface high precision air brush. gelatin-chondroitin layers cross-linked glutaraldehyde. Results: content uniformity was within 100 ± 5%, thickness of polymer layer 410 5.2 μm. vitro release studies showed biphasic pattern an initial burst followed by slow up...
Hydroxytyrosol (HT), a naturally occurring polyphenol from the olive plant, is potent antioxidant, cardioprotective, neuroprotective, and anti-inflammatory agent. Upon oral administration, HT undergoes rapid elimination within minutes thus limiting its therapeutic utility. Due to hydrophilic nature, percutaneous absorption transdermal delivery of are very low. The aim this research was enhance skin permeation hydroxytyrosol using niosome gel formulation. formulations prepared with Span 60 as...
Daunorubicin (DNR) and cardiolipin (CL) were co-delivered using thermosensitive liposomes (TSLs). 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (MSPC), cholesterol, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] or DSPE-mPEG (2000) CL used in the formulation of at a molar ratio 57:40:30:3:20, respectively. forms raft-like microdomains that may relocate change lipid organization outer inner...
Therapeutic strategies for ARID1A-mutant ovarian cancers are limited. Higher basal reactive oxygen species (ROS) and lower glutathione (GSH) empower the aggressive proliferation ability strong metastatic property of OCCCs, indicated by increased marker epithelial-mesenchymal transition (EMT) serving immunosuppressive microenvironment. However, aberrant redox homeostasis also empowers sensitivity DQ-Lipo/Cu in a mutant cell line. DQ, carbamodithioic acid derivative, generates dithiocarbamate...