A5036260969- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Occupational exposure and asthma
- Indoor Air Quality and Microbial Exposure
- IL-33, ST2, and ILC Pathways
- Healthcare and Environmental Waste Management
- Municipal Solid Waste Management
- IoT and GPS-based Vehicle Safety Systems
- Orthopedic Surgery and Rehabilitation
- Elevator Systems and Control
- Operations Management Techniques
- Sports injuries and prevention
- Viral-associated cancers and disorders
- Body Contouring and Surgery
- Food Drying and Modeling
- Otolaryngology and Infectious Diseases
- Vitamin D Research Studies
- Total Knee Arthroplasty Outcomes
- Immunotherapy and Immune Responses
- Antimicrobial Resistance in Staphylococcus
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
Roswell Park Comprehensive Cancer Center
2024
Cancer Genetics (United States)
2024
University of Wisconsin–Madison
2016-2024
The Royal Wolverhampton NHS Trust
2024
TScan Therapeutics (United States)
2023-2024
Vellore Institute of Technology University
2022-2023
SRM Institute of Science and Technology
2023
Florida State University
2021
Vardhman Mahavir Medical College & Safdarjung Hospital
2016
North Dakota State University
2013
Epstein-Barr virus (EBV) infection causes B cell lymphomas in humanized mouse models and contributes to a variety of different types human lymphomas. T cells directed against viral antigens play critical role controlling EBV infection, EBV-positive are particularly common immunocompromised hosts. We previously showed that induces with high frequency cord blood-humanized model which EBV-infected blood is injected intraperitoneally into NOD/LtSz-scid/IL2Rγnull (NSG) mice. Since our former...
A central issue for adoptive cellular immunotherapy is overcoming immunosuppressive signals to achieve tumor clearance. While γδ T cells are known be potent cytolytic effectors that can kill a variety of cancers, it not clear whether they inhibited by suppressive ligands expressed in microenvironments. Here, we have used powerful preclinical model where EBV infection drives the de novo generation human B cell lymphomas vivo, and autologous lymphocytes held check PD-1/CTLA-4–mediated...
Abstract By binding to its ligand ICAM-1, LFA-1 is known mediate both adhesion and costimulatory signaling for T cell activation. The constitutively high surface expression of invariant NKT (iNKT) cells has been shown be responsible their distinctive tissue homing residency within ICAM-rich endothelial vessels. However, the functional impact on activation iNKT other innate lymphocyte subsets remained largely unexplored. In particular, it not clear whether contributes innate-like pathways...
Invariant natural killer T (iNKT) cells are innate lymphocytes that promote host defense against a variety of microbial pathogens. Whether ligands required for their protective effects remains unclear. Here, we show iNKT stimulate human-monocyte-derived dendritic (DCs) to produce inflammatory mediators in manner does not require the presence compounds. Interleukin 2 (IL-2)-exposed selectively induced repeated cytoplasmic Ca(2+) fluxes DCs were dependent on signaling by P2X7 purinergic...
Abstract The cytokine IL-1β plays a central role in inflammatory responses that are initiated by microbial challenges, as well those due to endogenous processes (often called sterile inflammation). secretion occurs independently of stimulation is typically associated with the presence alarmins, such extracellular ATP (an indicator cytopathic damage). In this study, we show IL-2–activated human invariant NKT (iNKT) cells stimulate protein peripheral blood monocytes manner requires neither...
Nutritional rickets can be treated by various regimes ranging from daily or weekly oral therapy to single highdose (stosstherapy) intramuscular therapy.The advantage of high-dose over other is avoidance dose, thereby increasing patient compliance and decreasing cost therapy.On the hand, main disadvantages are injection site morbidity potential complication vitamin D toxicity.Stosstherapy has been used since early 19 th century for treating (4).However, there no clear cut
Elevators have found use almost everywhere in the modern society. They are used residential buildings, commercial hospitals, malls, industries, et cetera. In fact, every building with more than 5 floors employs of elevators. This extensive elevators is also accompanied by instances failure machine. Often, people stuck for hours, and severe cases, such failures may cause loss life. Thus, entailing need a system deployable time an emergency. paper thus focuses on creation Internet Things...
Abstract Objectives: Methicillin-resistant Staphylococcus aureus infections are becoming an increasing problem, but the link with symptomatic sino-nasal infection has not previously been quantified. The aim of this study was to determine incidence methicillin-resistant in patients undergoing surgery. Design: A retrospective case notes. Setting: district general hospital. Patients: One hundred and fifty-one adult in-patient endonasal surgery over a 12-month period were considered for study....
Invariant natural killer T (iNKT) cells are a conserved population of innate lymphocytes that uniquely suitable as off-the-shelf cellular immunotherapies due to their lack alloreactivity. Two major subpopulations human iNKT have been delineated, CD4
Abstract iNKT cells are innate-like CD1d-restricted T that mediate potent anti-tumor responses in murine models and have shown therapeutic potential clinical trials. In humans, expression of CD4 delineates two functionally distinct cell subsets, with CD4- mainly producing TH1 cytokines showing cytolytic activity, while CD4+ display a polyfunctional phenotype linked to regulatory pathways. Here, we used an EBV-driven B-lymphoma model investigate the effects these subsets. live imaging system,...
Aims Arthroplasty has been shown to generate the most waste among all orthopaedic subspecialties, and it is estimated that hip knee arthroplasty in excess of three million kg annually UK. Infectious generates up ten times more CO2 compared with recycled waste, previous studies have over 90% infectious stream misallocated. We assessed effect real-time segregation by an unscrubbed team member on generation cases, this a simple educational intervention during ‘team brief’ at start operating...
<h3>Background</h3> While T cell receptor (TCR)-engineered (TCR-T) therapy has transformed the landscape of cancer immunotherapy, efficacy and durability response are often limited by tumor heterogeneity, antigenic escape, loss heterozygosity. Treatment solid tumors with multiple TCR-Ts specific for different antigens restricted to several human leukocyte (HLAs) is a promising strategy overcome immune evasion, potentially increase TCR-T therapy. MAGE-A4 expressed in malignancies, including...
Waste segregation is a top priority in many countries across the world. Even this day and age, individuals are unable to discern between biodegradable, recyclable, landfill waste. As result, world currently dealing with serious basic issue garbage disposal. In study, we use deep learning algorithms handle trash categorization problem. Organic waste, recyclable rubbish, three major types of A way speed up whole process by doing waste sorting, which could be done computer using image...
<h3>Background</h3> Engineered T cell therapy holds great promise for treating solid tumors. To date, clinical investigations of TCR-T therapies have targeted one antigen/HLA at a time and produced encouraging but partial response rates with limited durations. While heterogeneity antigen expression is appreciated as likely driver patient relapse, the contribution HLA loss heterozygosity (LOH), occurring in up to 40% tumors, only now gaining attention. address both LOH requires collection...