Bis(3-amino-1-hydroxybenzyl)diselenide containing two ortho groups was synthesized from 7-nitro-3H-2,1-benzoxaselenole and in situ generated sodium benzene tellurolate (PhTeNa). One-pot synthesis of 1,3-benzoselenazoles achieved bis(3-amino-1-hydroxybenzyl)diselenide aryl aldehydes using acetic acid as a catalyst. The X-ray crystal structure chloro-substituted benzoselenazole revealed planar with T-shaped geometry around the Se atom. Both natural bond orbital atoms molecules calculations...

Copper-catalyzed direct selenation of substituted 2-bromo-N-phenylbenzamide substrates with elemental selenium powder provided a series methoxy-substituted isoselenazolones via the C-Se and Se-N bond formations. Phenolic have been obtained by O-demethylation corresponding analogues using boron tribromide. Some structurally characterized X-ray single-crystal analysis. The glutathione peroxidase (GPx)-like antioxidant activity has evaluated both in thiophenol coupled-reductase assays. All...

In the present study, extract from stem of Euphorbia neriifolia was used to investigate its antioxidant and antidiabetic activity. The potential investigated in streptozotocin-induced diabetic rats. Standard phytochemical methods were for qualitative quantitative studies. scavenging activity 2,2-diphenyl-2-picrylhydrazyl hydrogen peroxide study hydroalcoholic (HAE). Plasma glucose content, lipid profiles, insulin levels, GLUT-4 protein content muscle homogenates, inhibition amylase...

The synthesis of diarylamine-based organoselenium compounds via the nucleophilic substitution reactions has been described. Symmetrical monoselenides and diselenides were conveniently synthesized by reduction their corresponding selenocyanates using sodium borohydride. Selenocyanates obtained from 2-chloro acetamides displacement with potassium selenocyanate. Selenides treating in situ generated butyl selenolate as nucleophile. Further, newly evaluated for glutathione peroxidase (GPx)-like...

From the oral health perspective, it is well established that microorganisms have an important role in caries aetiology. dawn of civilization, herbal plants served array roles. Triphala a tradtional Ayurvedic formula consists three native fruits india including Terminalia Chebula (T. chebula), Bellirica bellirica) and Embilica Officinalis (E. officinalis). As per Formulary India (AFI) prepared by combining 1:1:1 mixture ground dry called myrobalans. Till date, inadequate number clinical...

<italic>N</italic>-Methyl ebselenamines carrying an aminic group in very close proximity to selenium as excellent chain-breaking and glutathione peroxidase-like antioxidants could reduce the production of ROS C6 astroglial cell lines with minimal toxic effects.

Antioxidants act as weapons to neutralize the damaging effects of free radicals that are produced in living systems during cellular activities and responsible for a number diseases.Plants major source antioxidants form enzymatic well non-enzymatic which is proved by several pieces research on various natural products have potent capability mimic deleterious radicals.Among antioxidants, such polyphenols, vitamins, carotenoids, glutathione, etc. been isolated screened anti-oxidant properties...

Background: Keeping in view the importance of natural plant products, bioactivity‑guided isolation phytoconstituents was attempted from Lawsonia inermis L. Materials and Methods: Various polar non‑polar extract/fractions were isolated evaluated for genotoxic antigenotoxic potential against mutagens viz., 4‑nitroquinoline‑1‑oxide nitrofurantoin SOS chromotest using Escherichia coli PQ37 tester strain H2O2 DNA protection assay. In order to decipher mode action, antioxidant activity different...

Abstract Selenazolonamines 10 a – d with free amine (‐NH 2 ) group, new series of preventive and radical‐trapping antioxidants were synthesized from their corresponding diselenides. The antioxidant capacity compounds was determined in chlorobenzene/water membrane‐like model system which azo ‐initiated peroxidation linoleic acid carried out the lipid phase. regeneration occurred aqueous ascorbic as co‐antioxidant, could regenerate enhance inhibition times. best substituted para ‐NMe strong...

Synthesis of N -thiophenyl ebselenamines and selenenyl sulphides as efficient radical-trapping hydroperoxide-decomposing antioxidants, respectively has been described.

Objective: To study the antioxidant activity of different extracts nuts Semecarpus anacardium in vitro . Methods: The antioxdant was investigated by two methods: estimating degree non-enzymatic haemoglobin glycosylation measured colorimetrically at 520 nm and assaying DPPH free radical scavenging activity. Results: It found that petroleum ether ethanol S. showed higher than other it. activities are close identical magnitude comparable to standard compounds used. were concentration dependant....

Phenolic organochalcogen chain-breaking antioxidants, i.e. 6-bromo-8 (hexadecyltellanyl)-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-9-ol and 2-methyl-2,3-dihydrobenzo[b]selenophene-5-ol, have been investigated in a two-phase (chlorobenzene/water) lipid peroxidation model system as potent inhibitors of peroxyl radicals with various co-antioxidants at pH values. The has significant effect on the antioxidant activities phenolic organochalcogens. key mechanism profile was attributed...

Retrieval of meaningful information out voluminous data available on the internet is a big challenge these days. Named entity recognition system deals with this efficiently and achieves promising results in accessing interest several NLP applications. The present study proposes deep learning-based named using hybrid embedding which combination fasttext bidirectional LSTM based character embedding. These embeddings capture contextual, syntactic semantic properties text improves cognitive...

Extraction of meaningful information from a huge amount data available on the web is quite challenging task. The challenges faced in extraction can be overcome with help an efficient named entity recognition (NER) system. Named entities are proper names that play important role searching interest. In this study, deep learning-based NER technique has been proposed which recognizes belonging to general domain Hindi, Punjabi, and bilingual Hindi Punjabi text. An variant recurrent neural...

In search for better synthetic antioxidants, aminic organoselenides carrying amine and benzamide groups at ortho‐positions to the selenium atom were synthesized from alkyl halides in situ generated sodiumselenolates as nucleophile by sodium borohydride reduction of corresponding diselenides. The single crystal X‐ray structure one compound showed weak intramolecular Se×××H interactions with free group. presence Se···H was confirmed using natural bond orbital (NBO) atoms molecules (AIM)...