A5074787404- Malaria Research and Control
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- Crop Yield and Soil Fertility
- RNA Interference and Gene Delivery
- Insect Pest Control Strategies
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Insect behavior and control techniques
- Smart Agriculture and AI
- Phytochemistry and Bioactivity Studies
- Ovarian cancer diagnosis and treatment
- Bacillus and Francisella bacterial research
- Advanced Drug Delivery Systems
- Legume Nitrogen Fixing Symbiosis
- Toxoplasma gondii Research Studies
- Remote Sensing in Agriculture
- Essential Oils and Antimicrobial Activity
- Potato Plant Research
- Antimicrobial agents and applications
- Hydrogels: synthesis, properties, applications
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
Jawaharlal Nehru Medical College
2024
Institute of Microbial Technology
2022-2024
Guru Angad Dev Veterinary and Animal Sciences University
2019-2024
Kathmandu University
2024
National Center for Disease Control
2024
Czech Academy of Sciences, Institute of Biotechnology
2024
Indian Agricultural Research Institute
2022
Romanian Academy
2022
Warsaw University of Technology
2022
Maharishi Markandeshwar University, Mullana
2022
Drought is significant abiotic stress that affects the development and yield of many crops. The present study to investigate effect arbuscular mycorrhizal fungi (AMF) biochar on root morphological traits, growth, physiological traits in soybean under water stress. Impact AMF spores number soil enzymes' activities were studied drought conditions. After 40 days, plant growth parameters measured. negatively affected parameters, microbial biomass, enzyme activities. Biochar individually increase...
Current strategies for phenotyping above-ground biomass in field breeding nurseries demand significant investment both time and labor. Unmanned aerial vehicles (UAV) can be used to derive vegetation indices (VIs) with high throughput could provide an efficient way predict forage yield accuracy. The main objective of the study is investigate potential UAV-based multispectral data machine learning approaches estimation oat biomass. UAV equipped a sensor was flown over three experimental fields...
Antimalarial drug resistance and unavailability of effective vaccine warrant for newer drugs targets. Hence, anti-inflammatory activity phyto-compound (oleuropein; OLP) was determined in antigen (LPS)-stimulated human THP-1 macrophages (macrophage model inflammation; MMI). Reduction the inflammation controlled by PI3K-Akt1 signaling to establish "immune-homeostasis." Also, OLP treatment influenced cell death/autophagy axis leading modulated extended survival. The findings with MII prompted...
Background: Rheumatoid arthritis (RA) is a common acute inflammatory autoimmune connective tissue arthropathy. The genetic studies, analyses, experimental animal models, and clinical investigations have confirmed that stromal damage pathology driven by RA mounts the chronic inflammation dysregulated immune events. Methods: We developed methotrexate (MTX)-loaded lipid-polymer hybrid nanoparticles (MTX-LPHNPs) aceclofenac (ACE)-loaded nanostructured lipid carriers (ACE-NLCs) for efficient...
The suboptimal efficacies of existing anti-malarial drugs attributed to the emergence drug resistance dampen clinical outcomes. Hence, there is a need for developing novel and targets. Recently silver nanoparticles (AgNPs) constructed with leaf extracts Euphorbia cotinifolia were shown possess antimalarial activity. Therefore, synthesized AgNPs from (EcAgNPs) tested their parasite clearance We determined activity in asexual blood stage infection 3D7 (laboratory strain) P. falciparum. EcAgNPs...
Drug resistance in Plasmodium falciparum presents a formidable challenge to the humanity. And, unavailability of an effective vaccine worsens situation further. Autophagy is one mechanisms employed by parasite evade drug pressure survive. induced P. response oleuropein may answer many questions related survival as well evolving tolerance. The survival/autophagy axis could be important avenue explore order address certain evolution resistance. In addition, humanized mouse model infection...
Breast cancer is one of the leading causes death among women globally, making its diagnosis and treatment challenging. The use nanotechnology for an emerging area research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes observed using SEM, while TEM structural integrity MWCNTs after functionalization. Particle...
The rickettsioses, except for typhus fever and scrub (ST), were not really recognized as distinct clinical entities until the early 20th century. Only when specific rickettsial serologic testing was introduced in 1940s could precise etiologies of various diseases (RDs) be determined with certainty. Although ST is a well- zoonotic disease entity, but non-scrub infection like spotted group are well studied India still underestimated.
Abstract Here in, we discuss different types of nanohydrogels in the field biomedicine, highlighting their unique properties such as size, biocompatibility, and tuneable drug release capabilities. Nanohydrogels are considered versatile tools for applications tissue engineering, delivery, diagnostics, with ability to target specific sites therapeutic agents a controlled manner. The controlled‐release characteristics particularly emphasized targeted potentially transforming therapies...
Sweet orange (Citrus sinensis Osbeck) is a highly profitable fruit crop of Nepal. However, for the past five years, farmers experienced poor productivity partly attributed to severe infestation exotic Chinese fly (Bactorcera minax), particularly in Sindhuli and Ramechhap district In this context, we attempted review on identification, life cycle, eco-friendly management fly. The documented based field visit relevant works literature from Journal articles, books, pamphlets, etc. has...
Introduction: Holi is a time of vibrant celebrations and joyful gatherings. However, amidst the hues festive fervour, it's crucial to safeguard your skin, hair nails from potential damage caused by harsh chemicals dyes. Aim: To study pattern cutaneous findings among people Garhwal region Uttarakhand following celebration. Methodology: This was hospital based cross-sectional conducted for period four weeks festival. Patients who attended dermatology outpatient department (OPD) with different...
The anti-inflammatory activity of a phytocompound (oleuropein [OLP]) in the lipopolysaccharide (LPS)-mimicked macrophage model inflammation demonstrates importance PI3K-Akt1 signaling establishing "immune homeostasis." Here, we present protocol for cultivation vitro cultures P. falciparum carrying out drug sensitivity assays. We describe steps parasite synchronization, treatment, DNA isolation, and starvation-induced autophagy. This provides insights into autophagy tolerance to pressure. For...
Gray zone lymphoma (GZL) is an extremely uncommon hematological cancer with characteristics in common both classical Hodgkin's (HL) and diffuse large B-cell lymphoma. In this case report, we present a rare of 22-year-old male who developed HL initially then transitioned to relapsed or refractory GZL. The disease twice throughout, even after the peripheral blood stem cell transplant. initial biopsy suggested it was HL, done late progression disease; features treatment consisted curative...
An emergency medical evaluation for ovarian torsion should be conducted on any female who complains of stomach pain. More women in the reproductive age range experience torsion. Ovarian presenting postmenopausal is an uncommon occurrence. Torsion ovaries can occur alone or with fallopian tubes. Pain main complaint, which may accompanied by swelling, nausea, etc. In this instance, we have a 52-year-old woman complained lower abdominal pain right side. A transvaginal ultrasonography (USG) was...
Deltamethrin is an insecticide used to control harmful agricultural insects that otherwise damage crops and vector-borne diseases. Long-term exposure deltamethrin results in the inflammation of lungs. The present study elucidates molecular mechanism underlying deltamethrin-induced lung damage. samples were extracted from Swiss albino mice following treatment low (2.5 mg/kg) high (5 doses deltamethrin. mRNA expression TCR, IL-4, IL-13 showed upregulation, while NFAT FOS was downregulated a...
Antioxidants reduce the risk of many diseases, including certain cancer and cardiovascular diseases. Medicinal plants can be a promising source essential antioxidants due to presence phytochemicals such as flavonoids, phenolic compounds. In these present paper comparative antioxidant properties Mimosa pudica, Vachellia nilotica, Leucas aspera, Phyllanthus Niruri, Hemidesmus indicus Adhatoda vasica has been studied. The total content, flavonoid assay, DDPH Radical Scavenging activity, ABTS...
Toxoplasma Gondii is an obligate, intracellular coccidian parasite with the ability to infect almost all warm-blooded species. While domestic cats and other felines are natural hosts, humans mammals intermediate hosts that can develop significant diseases in immunocompromised people or developing fetuses. In healthy individuals intact immune systems, clinical disease rare. Around 30 million thought have a Toxoplasmosis-related infection, 20%-60% of get diagnosed Toxoplasmosis. The main...