Libraries of benzoxanthenes, as well benzochromenes, were efficiently synthesized via one-pot, three-component reactions 2-naphthol, aldehydes, and cyclic 1,3-diketones/malononitrile/ethyl cyanoacetate in the presence catalytic amount ceric ammonium nitrate (CAN) under solvent free conditions. The protocol offers rapid synthesis structurally diverse benzoxanthenes benzochromenes for biologically screening. All compounds evaluated their anti-proliferative activity, several exhibiting...

Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration corresponding N-substituted formamides, several representative isocyanide-based organic reactions successfully performed. DIPEA = N,N-diisopropylethylamine.

A grinding-induced catalyst- and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), malononitrile/ethyl cyanoacetate. The synthesized were efficiently converted into novel tacrine analogs 7a–7e micelle-promoted microwave irradiation.

Putting osmium in its place: The immobilization of hazardous OsO4 on polymer nanobrushes a microreactor is safe, effective, and green concept. method allows reactions to be performed time- chemical-saving manner, with little environmental impact, as compared spill-over bulk processes.

Generation of hydrogen from renewable sources and its safe utilization for efficient one-pot upgrading biofuels are a challenge. Bimetallic PdAg catalyst supported on Fe3O4/nitrogen-doped reduced graphene oxide (N-rGO) were synthesized generation formic acid with high TOF (497 h–1 at 50 °C), the was subsequently utilized in situ selective defunctionalization lignin-derived chemicals preserved aromatic nature ambient pressure. Hydrodeoxygenation aldehydes ketones gave excellent yields (99%...

The sustainable green chemistry associated with lignocellulosic biomass is of current interest for producing various chemical feedstocks via multi-step transformation processes. Here we introduce a platform system the multicomponent cascade natural resources. We demonstrate concept by developing an integrated continuous two-step microfluidic as tandem direct conversion fructose to diverse furan chemicals excellent yields up 99% decarbonylation, etherification, oxidation and hydrogenolysis...

We present an electrochemical alkylation of azauracils using N-(acyloxy)phthalimides (NHPI esters) as readily available alkyl radical progenitors under metal- and additive-free conditions. Several are shown to undergo with array NHPI esters (1°, 2°, 3°, sterically congested), providing the desired products in good excellent yields. This operationally simple method is robust, scalable, suitable for both batch flow setups.

AbstractAging is associated with increased production of reactive oxygen species (ROS) and oxidation-induced damage to intracellular structures membranes. Caloric restriction (CR) has been demonstrated delay aging in a variety species. Although the mechanisms CR remain be clearly elucidated, reductions oxidative have shown increase lifespan several model systems. Contrary general belief that ROS reduced CR, this article provides evidence not only consumption but enhanced calorie restricted...

We report here a novel IBX-promoted oxidative coupling of primary amines and its utilization to Ugi reaction. Advantageously, the reaction could be carried out in choline chloride urea as natural deep eutectic solvent. A range imines bisamides from pseudo-four-component synthesized under mild metal-free conditions. oxidant (IBX) solvent recycled up five times with only slight loss activity.

This work discloses an electrochemical oxidative cross-coupling of amines with aryl and aliphatic isocyanides. In undivided cell, the reaction proceeds without involving any transition-metal catalyst, oxidant, or toxic reagents providing carbodiimides in good yields, thereby circumventing stoichiometric chemical oxidants, H2 as only byproduct. Moreover, were situ converted into unsymmetrical ureas moderate to yields using electricity ON–OFF strategy.

Indolizine derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we report a novel electro-oxidative cascade cyclization reaction that uses electricity as the primary energy input to promote reaction, leading series of heterocyclic substituted indolizine under exogenous-oxidant-free conditions. It is noteworthy this electrochemical method provides strategy for generating diversity quinazolinones quinolines on indolizines. In addition, sole...

Abstract We have successfully developed a single nucleotide (adenosine 5′‐diphosphate)‐catalyzed enantioselective direct reductive amination of aldehydes and ketones using Hantzsch ester as reducing agent. The process is simple, efficient real mimic the NADH reduction approach for synthesis structurally diverse amines. This reaction first report demonstrating ability catalyst one most genuine biomimetic reactions organic chemistry.

Here, we demonstrate that graphene oxide (GO) can be converted to N-doped reduced GO (rGO) could become a substitute for graphene.

Metal catalyzed post-Ugi cyclization of bis-amides is reported in this study. Exposure to Pd(II) catalyst triggered the formation seven-membered benzoxazepinones. This investigation established that changing a Echavarren’s gold(I) turned off seven member ring and on 6-exo-dig annulations afford family six-membered benzoxazinones. To support proposed mechanisms, quantum chemical based density functional theory calculations have been performed validated. novel method obtained molecular...

A metal-free diastereo-/regioselective modular synthetic approach for the synthesis of highly constrained tetrahydroquinoline-fused tetracyclic heterocycles from easily available substrates has been developed. This two-step strategy utilizes an Ugi four-component reaction, followed by intramolecular spirocarbocyclization and iodination reactions in a single operation. The transformation is mild operationally simple, which provides architecturally complex polycyclic with high...

A novel electrochemical cross-dehydrogenative C-S bond coupling of aryl thiols with 2H-indazole is reported. Thiol-functionalized 2H-indazoles were synthesized under catalyst-, oxidant-, and metal-free conditions innocuous hydrogen as the sole byproduct at ambient temperature. Furthermore, continuous flow using a graphite/Ni cell used to obtained 3-(arylthio)-2H-indazole compounds on gram scale within residence time 39 min. Detailed mechanistic studies including control experiments cyclic...

The combination of the Ugi reaction and electro-organic synthesis can aid in creation novel heterocycles that have not been previously explored. In this study, a new strategy utilizing bis-amides from has developed, which produce C–S, C–Se, C–C═O functionalized five-membered spirolactams mediated by electricity under catalyst- metal-free conditions. Notably, approach be applied using microelectro-flow reactor (μ-EFR) for gram-scale synthesis. described synthesize complex azaspiro-fused...

The quest to reduce greenhouse gases has triggered the development of new chemical fixation carbon dioxide.