A5014188994- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Dendrimers and Hyperbranched Polymers
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Chemical Synthesis and Analysis
- Metal complexes synthesis and properties
- Synthesis of Tetrazole Derivatives
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Curcumin's Biomedical Applications
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Organometallic Compounds Synthesis and Characterization
- Asymmetric Synthesis and Catalysis
- Chemistry and Chemical Engineering
- Synthesis of β-Lactam Compounds
- Microwave-Assisted Synthesis and Applications
- Ferrocene Chemistry and Applications
- Bone Tissue Engineering Materials
- Hair Growth and Disorders
- Composting and Vermicomposting Techniques
Bhabha Hospital
2024
Lalit Narayan Mithila University
2018-2023
Laboratoire de Chimie de Coordination
2017-2021
Centre National de la Recherche Scientifique
2018-2021
Université de Toulouse
2021
Shyam Shah Medical College
2020
Netaji Subhash Chandra Bose Medical College
2013-2020
Central Drug Research Institute
1978-2019
Darbhanga Medical College and Hospital
2018
Medical College and Hospital, Kolkata
2015-2017
An efficient and green method has been developed for the synthesis of tryptanthrin employing β-cyclodextrin as a catalyst in aqueous media at room temperature from isatoic anhydride isatin. The reactions were performed under mild conditions to afford biologically active natural product excellent yields.
Abstract Coordination compounds and organometallics have very special place in chemistry due to their different structural arrangements application various fields. They also play vital role biological system particularly human plant life. The blood oxygen carrier haemoglobin is a coordination compound of iron which essential for life, the chlorophyll magnesium life continuation on this planet. These are not only biologically important but comprise group drug like molecules medicines. such as...
The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability the drug is main factor for therapeutic failure, which development cases. Therefore, there an urgent need design develop novel antimycobacterial agents minimizing period reducing propagation resistance at same time. Here, we report original noncytotoxic polycationic phosphorus dendrimers...
An efficient new multicomponent protocol for the C-3 functionalization of indoles with dihydrocoumarin has been developed using an artificial sweetener (saccharin)-based functional ionic liquid (imidazolium saccharinate). The reaction consists Knoevenagel coupling salicylaldehyde and Meldrum's acid followed by a Michael type indole, resulting in concomitant lactonization via decarboxylative elimination to yield indole-3-dihydro-coumarins good excellent yields at room temperature.
Abstract In this study, the ligands based on azo dye of 3,6- diamino-10-methyl acridinium chloride (MAA) and its complexes Co(II) Cu(II) were synthesized characterized successfully via mass, UV-Vis, infrared spectroscopy elemental analysis.The energies HOMO LUMO orbitals MAA ligand calculated density functional theory (DFT). The orbital is appropriate to donate electron injection condition band TiO 2 . energy was 1.8 eV which encourages using it a sensitizing in dye-sensitized solar cells....
The distribution of stress on short platform switched dental implants is interest. Hence, the mandibular posterior molar area was modelled using a three-dimensional finite element method (FEM) with continuous 1.5 mm cortical bone thickness and an inner cancellous core. used in study were 5 long, 4.5 wide 3.5 at abutments. 120 N force applied both vertical oblique (20° 35°) directions to create realistic simulation. ANSYS Workbench generated for each model. Von Mises assessed bones varying...
A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use Surfactant, water as reaction medium, room temperature, high yield ease purification made the process very effective ecofriendly in nature. To demonstrate wide scope Isatoic anhydride Isatin used reactants different sets reactions that leads to formation Quinazolinones spiroquinazolinones. total...
In present work, we have reported the synthesis and characterisation of novel hexahydrospiro[indoline-3,3′-pyrrolizine]-2-one derivatives in good to excellent yields via [3+2] cycloaddtion reaction regioselective manner. These compounds were synthesized multicomponent substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline at room temperature. All hexahydrospiro molecules characterized by 1H 13C NMR, IR spectra, mass spectra elemental analysis. Regioselectivity also...
Background: The role of uric acid as a risk factor in cases acute ischaemic stroke is controversial. present study was conducted with the aim to clinical profile and incidence patients normal elevated its correlation other factors.Methods: This 100 who were admitted NSCB Hospital Jabalpur from August 2009 July 2010.Clinical records their serum level investigated. severity neurological deficit recorded according scandinavian scale (SSS). Patients followed up during hospital stay outcome...
An efficient β-cyclodextrin catalyzed multicomponent synthetic protocol has been developed for the synthesis of spiro[indoline-3,2'-quinazoline]-2,4'(3’H)-dione from isatoic anhydride, isatin and primary amine in aqueous medium. This methodology offers a convenient method spiroindole quinazolines excellent yields. To extend utility some dihydro have also synthesized.
Background: Rheumatic heart disease remains a considerable cause of cardiovascular morbidity and mortality in developing countries such as India. The aim the present study was to compare ventricular (LV RV) function patients with severe mitral stenosis (MS) undergoing balloon Valvuloplasty (BMV) those on medical management also healthy controls assess burden systolic dysfunction, its determinants, reversibility percutaneous using speckle tracking echocardiography MS.Methods: This prospective...
Background: Diabetes mellitus and Metabolic syndrome, both are established risk factors for CAD. In our study, we tried to compare the effects of these two diseases individually as well their combined effect.Methods: performed an Observational, cross-sectional, hospital-based, single center study on 240 patients presenting at hospital with chest pain. assessed severity CAD Syntax score divided population into three groups SS <=22, 23-32 >=33.Results: statistically significant...
A series of substituted curcumin analogues have been designed and synthesized via condensation reaction benzaldehydes dehydroacetic acid. Synthesized molecules were further evaluated for their inhibitory activity against various cancer cell lines. Most the compounds significantly inhibited growth these Ten most active in screened to check effect filarial topoisomerase II enzyme. All exhibited excellent inhibition upto percentage more than 95 %. Further, structure-activity relationships...
Present work demonstrates a facile synthesis of series 20 dihydropyrazole derivatives from well designed curcumin analogues by reaction chalcone with phenylhydrazine. All the synthesized compounds were characterized spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data elemental analysis. Synthesized dihydropyrazoles have diversity points on attached phenyl ring. Effect substituent reactivity was explained basis electronic effect generated due to groups Presence dd...
Background: Insulin resistance is the essential defect in development of type 2 diabetes mellitus, hypertension and cardiovascular diseases. The aim present study was to evaluate correlation between insulin resistance, metabolic syndrome their associated factors hypertensive patients.Methods: This comparative conducted on 100 patients who attended Department Medicine, NSCB Medical College, Jabalpur, Madhya Pradesh, India. 50 both sexes having were participated considered as group. Other...