A5051496452- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Bacterial Infections and Vaccines
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- Neurological Complications and Syndromes
- COVID-19 Impact on Reproduction
- Advanced Breast Cancer Therapies
- Neonatal and fetal brain pathology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- RNA Research and Splicing
- Antibiotic Resistance in Bacteria
- RNA regulation and disease
- Cancer Cells and Metastasis
University of Minnesota, Duluth
2015-2019
Ovarian cancer is a complex disease marked by tumor heterogeneity, which contributes to difficulties in diagnosis and treatment. New molecular targets better profiles defining subsets of patients are needed. tRNA fragments (tRFs) offer recently identified group noncoding RNAs that often as abundant microRNAs cells. Initially their presence deep sequencing data sets was attributed the breakdown mature tRNAs, however, it now clear they actively generated function multiple regulatory events....
Mycobacterium tuberculosis releases membrane vesicles (MV) that modulate host immune responses and aid in iron acquisition, although they may have additional unappreciated functions. MV production appears to be a regulated process, but virR remains the only characterized genetic regulator of vesiculogenesis. Here, we present data supporting role for M. Pst/SenX3-RegX3 signal transduction system regulating production. Deletion pstA1, which encodes transmembrane component phosphate-specific...
Preeclampsia is a prevalent pregnancy complication characterized by new-onset maternal hypertension and inflammation, with placental ischemia as the initiating event. Studies of others have provided evidence for importance lymphocytes in ischemia-induced hypertension; however, contributions B1 versus B2 are unknown. We hypothesized that peritoneal important hypertension. As an initial test this hypothesis, effect anti-CD20 depletion on both B-cell populations was determined reduced...
Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insufficiency the initiating event. Cigarette smoking during pregnancy decreases risk of preeclampsia. Nicotine, major component cigarettes, stimulates efferent cholinergic...
Abstract ELF5 is a master regulator of breast lobular development, enriched in luminal progenitor cells and has been implicated carcinogenesis may be chemopreventive biomarker target. In our laboratory, mammary cancer prone mice treated with the anti-estrogen tamoxifen have fewer hyperplastic lobules, reduced mRNA expression tumor incidence. also expressed multiple cell lines clinical tumors predominantly basal phenotype. However, presence not strictly negative factor, as forced aggressive...
Preeclampsia is characterized by new onset hypertension during pregnancy, reduced placental perfusion, and increased activation of complement, part the innate immune system. In uterine perfusion pressure (RUPP) model ischemia‐induced in rat, our previous work demonstrated importance complement activation, particularly products C3a C5a, mediating maternal hypertension. addition, we have deposition IgM component C3 placenta following ischemia suggesting a potential role for natural antibody...
Preeclampsia is a pregnancy specific disease characterized by new‐onset maternal hypertension and increased systemic inflammation, including complement activation. Although the exact pathophysiology unknown, abnormal arterial remodeling placental insufficiency have been implicated as initiating events. Studies of others provided evidence for importance B cell in ischemia‐induced hypertension, but contribution B1 lineage innate lymphocytes vs. traditional B2 unknown. Our previous studies...