A5025900583- 3D Printing in Biomedical Research
- Computational Drug Discovery Methods
- Nanoparticles: synthesis and applications
- Bacteriophages and microbial interactions
- Graphene and Nanomaterials Applications
- Protein Structure and Dynamics
- Extracellular vesicles in disease
- Supramolecular Self-Assembly in Materials
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Fuel Cells and Related Materials
- Metamaterials and Metasurfaces Applications
- Advanced Battery Materials and Technologies
- Orbital Angular Momentum in Optics
- MXene and MAX Phase Materials
- Advanced biosensing and bioanalysis techniques
- Additive Manufacturing and 3D Printing Technologies
- Wound Healing and Treatments
- Plasmonic and Surface Plasmon Research
- nanoparticles nucleation surface interactions
- Nanotechnology research and applications
- Molecular spectroscopy and chirality
- Advanced Nanomaterials in Catalysis
- Bioinformatics and Genomic Networks
- Bone Tissue Engineering Materials
Boğaziçi University
2025
University of Michigan
2018-2024
BioSurfaces (United States)
2018-2024
Brigham and Women's Hospital
2009-2012
Bluebird Bio (United States)
2009-2010
Harvard University
2009-2010
Zinc oxide nanoparticles cause marked up-regulation of pyrimidine biosynthesis and sugar metabolism but consistent down-regulation amino acid synthesis in MRSA, suggesting a previously unrecognized mechanism action.
Chiral plasmonic surfaces with 3D “forests” from nanohelicoids should provide strong optical rotation due to alignment of helical axis propagation vector photons. However, such three-dimensional nanostructures also demand multi-step nanofabrication, which is incompatible many substrates. Large-scale photonic patterns on polymeric and flexible substrates remain unattainable. Here, we demonstrate the substrate-tolerant direct-write printing patterning silver out-of-plane orientation using...
Development of new methods for analysis protein-protein interactions (PPIs) at molecular and nanometer scales gives insights into intracellular signaling pathways will improve understanding protein functions, as well other nanoscale structures biological abiological origins. Recent advances in computational tools, particularly the ones involving modern deep learning algorithms, have been shown to complement experimental approaches describing rationalizing PPIs. However, most existing works...
Tissue engineering based on building blocks is an emerging method to fabricate 3D tissue constructs. This requires depositing and assembling (cell-laden microgels) at high throughput. The current technologies (e.g., molding photolithography) microgels have throughput challenges provide limited control over block properties cell density). cell-encapsulating droplet generation technique has potential address these challenges. In this study, we monitored individual for viability, proliferation...
Abstract Chirality is an essential geometric property unifying small molecules, biological macromolecules, inorganic nanomaterials, microparticles, and many other chemical structures. Numerous chirality measures have attempted to quantify this of mirror asymmetry correlate these with physical properties. However, their utility has been widely limited because correlations largely notional. Furthermore, also require prohibitively demanding computations, especially for chiral structures...
The incessant mutations of viruses, variable immune responses, and likely emergence new viral threats necessitate multiple approaches to novel antiviral therapeutics. Furthermore, the agents should have broad-spectrum activity be environmentally stable. Here, we show that biocompatible tapered CuS nanoparticles (NPs) efficiently agglutinate coronaviruses with binding affinity dependent on chirality surface ligands particle shape. L- penicillamine-stabilized NPs left-handed curved apexes...
Self-assembled compartments from nanoscale components are found in all life forms. Their characteristic dimensions 50-1000 nm scale, typically assembled a variety of bioorganic "building blocks". Among the various functions that these mesoscale carry out, protection content environment is central. Finding synthetic pathways to similarly complex and functional particles technologically friendly inorganic nanoparticles (NPs) needed for multitude biomedical, biochemical, biotechnological...
Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization high throughput fabrication the main challenges. To address these in this study, feasibility of bioprinting cell-laden hydrogel to fabricate at was investigated response tracked by using lensless charge-coupled device (CCD) technology. This study indicated that (i) a collagen printing platform capable immobilizing cells (smooth...
Manipulation and encapsulation of cells in microdroplets has found many applications various fields such as clinical diagnostics, pharmaceutical research, regenerative medicine. The control over the number individual droplets is important especially for microfluidic bioprinting applications. There a growing need modeling approaches that enable within droplets. In this study, we developed statistical models based on negative binomial regression to determine dependence per droplet three main...
Cell printing is an emerging technology for engineering complex 3D tissue/organ structures. In this study, the proliferation of primary rat bladder smooth muscle cells (SMCs) in printed cell-laden collagen droplets was quantified. The results showed that bioprinting system capable viable cells, while keeping their ability a matrix.
<title>Abstract</title> <bold>Processes of self-replication, engineered using (bio)organic molecules and amphiphilic microdroplets, reveal fundamental requirements for the origin life </bold><italic><bold>(1–4). </bold></italic><bold>However, their practical significance is limited by absence higher-level organization in newly formed chemical species. The next generation self-replicating systems should include emergence partial order although realization chemically challenging....
Bioinspired ion transport membranes have been extensively researched for energy storage applications. Sulfur, due to its natural abundance, low toxicity, high theoretical specific density (2600 Wh/kg), and capacity (1675 mA/g), is attracting significant attention as an alternative battery system replace traditional lithium-ion batteries that limitations in terms of safety, capacity, various However, polysulfide dissolution shuttling pose challenges prevent the mass commercialization metal...
Abstract The emergence of new viral threats, wide applications viruses in biotechnology and challenges associated with contamination necessitate multiple types virustatic agents. Here, we show that highly biocompatible tapered CuS nanoparticles efficiently agglutinate COVID virus binding affinity dependent on chirality surface ligands particle shape. L- penicillamine-stabilized left-handed curved apexes display half-maximal inhibitory concentration as low 0.57 pM for authentic SARS-CoV-2...
Multicompartment Supraparticles In article number 2211244, J. Scott VanEpps, Nicholas A. Kotov, and co-workers report how l-cysteine-stabilized FeS2 nanoparticles self-assemble into supraparticles with multiple interconnected compartments. Their structure can be described by graph theoretical representations that show similar organization complexity to those of viruses. Similarly the latter, inorganic pack nucleic acid cargo for intracellular delivery while protecting it against...
Abstract Background Development of new methods for analysis protein-protein interactions (PPIs) at molecular and nanometer scales gives insights into intracellular signaling pathways will improve understanding protein functions, as well other nanoscale structures biological abiological origins. Recent advances in computational tools, particularly the ones involving modern deep learning algorithms, have been shown to complement experimental approaches describing rationalizing PPIs. However,...
Chiral metasurface with orthogonal nanohelical metal arrays provide strong optical rotation but demands multi-step nanofabrication at low-pressure and/or high-temperature conditions, which is incompatible many substrates and high-throughput assessment. Submillimeter local photonic patterns various polarization were also hitherto unattainable over the same substrate. Here, we demonstrate direct substrate-tolerant printing of silver nanohelicoids a locally variable activity using circularly...
Abstract Small extracellular vesicles, often termed as “exosomes” carry informative cargo containing proteins and lipids, reflective of their cellular origin. Thus, they are promising biomarkers for early diagnosis cancer. However, conventional profiling methods like quantitative polymerase chain reaction (qPCR) require complex procedures, thereby limiting the analytical sensitivity exosomes liquid biopsies. Here, we demonstrate a sensitive microfluidic device (CDEXO) that isolates profiles...
Bioinspired ion transport membranes have been widely investigated for energy storage applications. High theoretical specific density (2600Wh/kg) and high capacity (1675mA/g) along with natural abundance low toxicity of sulfur attracting significant attention development an alternative battery system to replace traditional lithium batteries which suffer from safety capacity/energy limitations in various However, challenges such as polysulfide dissolution shuttling prevent mass...