A5064487009- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Structural Characterization
- Cannabis and Cannabinoid Research
- Dermatology and Skin Diseases
- Bacterial biofilms and quorum sensing
- Hair Growth and Disorders
- Neurotransmitter Receptor Influence on Behavior
- Neurogenetic and Muscular Disorders Research
- Psychedelics and Drug Studies
- Cytomegalovirus and herpesvirus research
- Wnt/β-catenin signaling in development and cancer
- Mast cells and histamine
- Transgenic Plants and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Delphi Technique in Research
- Antifungal resistance and susceptibility
- Forensic Toxicology and Drug Analysis
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Microbial Metabolism and Applications
- Hereditary Neurological Disorders
- Hops Chemistry and Applications
University Medical Center Groningen
2010-2024
University of Groningen
2008-2024
The objective of this study was to identify and specify the problems children with epidermolysis bullosa. questions explored were: (i) What do bullosa experience as most difficult problems; (ii) is impact these on their daily life; (iii) Do experiences differ between mildly severely affected children? Qualitative research methodology used, comprising a series semi-structured interviews different (sub)types were analysed systematically help qualitative software package Atlas-ti. Five main...
Abstract Background Epidermolysis bullosa (EB) is a heterogeneous group of rare and incurable genetic disorders characterized by fragility the skin mucosae, resulting in blisters erosions. Several epidemiological studies other populations have been carried out, reporting varying sometimes inconclusive figures, highlighting need for standardized analyses well‐characterized cohorts. Objectives To evaluate data on EB Netherlands, extracted from molecularly cohort Dutch Registry. Methods In this...
Epidermolysis Bullosa (EB) is a rare genetic blistering-skin disorder with varying degrees of severity, ranging from mild forms to severe forms, chronic progression. The aim this study was identify and specify the problems parents child EB. Qualitative research methodology used, comprising series semistructured interviews eleven families. key were broken down into three themes, related child, family, care providers. These themes comprised nine categories, including (1) being different, (2)...
Junctional epidermolysis bullosa, type Herlitz (JEB-H) is a rare, autosomal recessive disease caused by absence of the epidermal basement membrane adhesion protein laminin-332. It characterized extensive and devastating blistering skin mucous membranes, leading to death in early childhood.To present results long-term follow-up cohort patients with JEB-H, provide guidelines for prognosis, treatment care.All JEB-H included Dutch Epidermolysis Bullosa (EB) Registry between 1988 2011 were...
Epidermolysis bullosa (EB) is a genetic blistering disorder characterized by intense pain related to disease pathology and care‐based interventions. Opioid‐based therapies underpin care in EB; however, they are unable provide adequate analgesia significant proportion of patients. Cannabinoid‐based medicines (CBMs) have been studied increasingly for conditions various aetiologies pose as novel dimension EB. We present three patients with EB who were prescribed pharmaceutical‐grade...
Epidermolysis bullosa (EB) is a group of rare inherited bullous skin disorders that differ in nature and severity. Currently, there no cure for the disease. One complex problems EB repetitive painful care wounds. The purpose this study was to explore how adult patients parents experienced impact wound during childhood which coping strategies they considered as helping. A qualitative performed, comprising semi-structured in-depth interviews with 7 6 parents. impact, physically,...
Human antibody responses to pathogens, like Staphylococcus aureus, are important indicators for in vivo expression and immunogenicity of particular bacterial components. Accordingly, comparing the S. aureus components may serve predict their potential applicability as antigens vaccination. The present study was aimed at assessing immunoglobulin G (IgG) elicited by non-covalently cell surface-bound proteins which thus far received relatively little attention. To this end, we applied plasma...
Abstract Background Epidermolysis bullosa (EB) patient anecdotes and case reports indicate that cannabinoid-based medicines (CBMs) may alleviate pain pruritus improve wound healing. CBM use has not been characterized in the EB population. Objectives To evaluate among patients, including types, effects on symptoms (e.g., pruritus), disease process blistering, wounds, inflammation), well-being sleep, appetite) concomitant medications. Methods English-speaking patients or caregivers completed...
Some subtypes of the heterogeneous genetic blistering disease epidermolysis bullosa (EB) lead to lethality in childhood. The severity and extent leaves these patients living excruciating pain distress their entire lives. Parents experience some specific problems, such as unfamiliarity EB amongst healthcare professionals suffering loss child.To identify needs parents who have lost child lethal EB.A qualitative study was performed, comprising semistructured, in-depth interviews with 16...
The opportunistic pathogen Staphylococcus aureus is known to interfere with wound healing and represents a significant risk factor for infections invasive disease. It generally assumed that one individual predominantly colonized by S. type. Nevertheless, patients the genetic blistering disease epidermolysis bullosa (EB) often carry multiple types. We therefore investigated whether different types are present in wounds of EB and, if so, how they spatially distributed. staphylococcal...
Epidermolysis bullosa (EB) is a genetic blistering skin condition for which no cure exists. Symptom alleviation and quality of life are therefore central to EB care. This study aimed gain insight into patient needs benefits from current clinical Two questionnaires were administered cross-sectionally adult patients at the Dutch expertise centre diseases. Patient analyzed using benefit index survey (PBI-S). Ancillary data compiled pertaining self-reported severity, pain pruritus, as well...
Several forms of epidermolysis bullosa (EB) present oral manifestations. Blistering the (peri)oral mucosa affects opening mouth, mobility tongue and lips, thereby restricting functions. We describe prevalence characteristics manifestations EB in relation to loss functions a cross-sectional study different types patients using standardized measurement techniques. Twenty-two were included. The mandible, lips was measured, mandibular function impairment questionnaire (MFIQ) filled out...
Wound-colonizing microorganisms can form complex and dynamic polymicrobial communities where pathogens commensals may co-exist, cooperate or compete with each other. The present study was aimed at identifying possible interactions between different bacteria isolated from the same chronic wound of a patient genetic blistering disease epidermolysis bullosa (EB). Specifically, this involved two isolates human pathogen Staphylococcus aureus, Bacillus thuringiensis Klebsiella oxytoca. Particular...
The opportunistic pathogen Staphylococcus aureus has become a major threat for human health and well-being by developing resistance to antibiotics fast evolution into new lineages that rapidly spread within the healthy population. This calls development of active or passive immunization strategies prevent treat acute phase infections. Since no such anti-staphylococcal approaches are available clinical implementation, present studies were aimed at identifying leads their development. For this...
Abstract Background Epidermolysis bullosa (EB) is a group of rare genetic skin disorders that primarily manifest as blisters and erosions following mild mechanical trauma. Despite the crucial role parents children with EB in managing disease, studies focusing on parent–child relationship remain gap literature. To address this gap, current quantitative study, involving 55 all types 48 parents, assessed between their quality life coping strategies. Quality was measured Pediatric Life Inventory...
Abstract Background Epidermolysis bullosa is a rare, often severe, genetic disorder characterized by fragility of the skin and mucous membranes. Despite important role parents during wound care, an essential factor in adapting to this disease, studies focusing on parent–child relationship care are scarce. The current study aimed at addressing gap. Methods A quantitative among 31 children (n = 21 ≤ 17 years; n 10 17–25 years) 34 (including 27 dyads) was conducted examine between pain, itch,...