A5057935632- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Quinazolinone synthesis and applications
- Dermatological diseases and infestations
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects of Natural Compounds
- Fungal Infections and Studies
- Cell Adhesion Molecules Research
- Antimicrobial Resistance in Staphylococcus
- Disaster Response and Management
- Immunotherapy and Immune Responses
- Leptospirosis research and findings
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Entomological Studies and Ecology
- Parasitic Infections and Diagnostics
- COVID-19 and healthcare impacts
- Ultrasound in Clinical Applications
- Vasculitis and related conditions
- Parasites and Host Interactions
- Fungal Biology and Applications
- Cancer therapeutics and mechanisms
- Hepatitis B Virus Studies
University Medical Center Hamburg-Eppendorf
2019-2024
Bernhard Nocht Institute for Tropical Medicine
2019-2024
Universität Hamburg
2019-2024
German Center for Infection Research
2022-2024
University of Groningen
2013-2020
Johns Hopkins University
2018-2020
World Health Organization
2019
Indiana University – Purdue University Indianapolis
2019
Nagasaki University
2019
National Center for Global Health and Medicine
2019
Addressing the transmission enigma of neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring causative agent, Mycobacterium ulcerans, and BU. Here tested contaminated skin model BU by dipping tails from healthy mice in cultures ulcerans. Tails were exposed to mosquito (Aedes notoscriptus Aedes aegypti) blood feeding or punctured with sterile needles. Two 12 M. ulcerans A. developed There no...
Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It most prevalent in western central Africa Australia. Standard antimicrobial treatment with oral rifampicin 10 mg/kg plus intramuscular streptomycin 15 once daily for 8 weeks (RS8) highly effective, but injections are painful potentially harmful. We aimed to compare efficacy tolerability of fully clarithromycin extended release (RC8) RS8 early lesions.
Buruli ulcer is a neglected tropical disease caused by Myocobacterium ulcerans; it manifests as skin lesion, nodule, or that can be extensive and disabling. To assess the global burden progress on control, we analyzed epidemiologic data reported countries to World Health Organization during 2010-2017. During this period, 23,206 cases of were reported. Globally, declined 2,217 in 2017, but local epidemics seem arise, such Australia Liberia. In 2013, formulated 4 programmatic targets for...
Mycobacterium ulcerans causes Buruli ulcer (BU), a debilitating infection of subcutaneous tissue. There is WHO-recommended antibiotic treatment requiring an 8-week course streptomycin and rifampicin. This regime has revolutionized the BU but there are problems that include reliance on daily injections side effects such as ototoxicity. Trials all-oral treatments for show promise additional drug combinations make safer shorter would be welcome. Following from reports avermectins have activity...
The antileprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment shortening when added to the first-line drug-susceptible tuberculosis in mouse model. However, causes dose- and duration-dependent skin discoloration patients, optimal dosing strategy context is unknown. We utilized well-established model systematically address impacts duration, dose, companion drugs on...
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash major risk factor for bacterial infections severe complications. Here, we evaluated treatment outcome of 2866 asylum seekers who received (preventive) scabies before during intervention programme (SIP) in main reception centre Netherlands between January 2014 March 2016. A SIP was introduced national based on frequent observations its complications amongst Eritrean Ethiopian Netherlands. On arrival, all from...
Background Buruli ulcer may induce severe disabilities impacting on a person's well-being and quality of life. Information about long-term participation restrictions is scanty. The objective this study was to gain insight into among former patients in Ghana Benin. Methods In cross-sectional study, were interviewed using the Participation Scale, Ulcer Functional Limitation Score measure functional limitations, Explanatory Model Interview Catalogue perceived stigma. Healthy community controls...
Telacebec (Q203) is a new antitubercular drug with extremely potent activity against Mycobacterium ulcerans . Here, we explored the treatment-shortening potential of Q203 alone or in combination rifampin (RIF) mouse footpad infection model. The first study compared at 5 and 10 mg/kg doses rifampin. rendered most footpads culture negative 2 weeks. Combining resulted relapse-free cure 24 weeks after completing treatment, to 25% relapse rate mice receiving RIF clarithromycin, current standard...
Potential differences in the breadth, distribution and magnitude of CD4
The opportunistic pathogen Staphylococcus aureus is known to interfere with wound healing and represents a significant risk factor for infections invasive disease. It generally assumed that one individual predominantly colonized by S. type. Nevertheless, patients the genetic blistering disease epidermolysis bullosa (EB) often carry multiple types. We therefore investigated whether different types are present in wounds of EB and, if so, how they spatially distributed. staphylococcal...
Abstract Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with autoimmune disease granulomatosis polyangiitis (GPA) is a risk factor for relapse. To date, it was neither known whether GPA show similar humoral immune responses to S. as healthy carriers, nor specific types are associated GPA. Therefore, this study aimed at assessing against antigens relation genetic diversity their isolates. A retrospective cohort conducted, including 85 and 18 controls (HC). Humoral...
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical skin and soft tissue infection that associated with disability social stigma. The mainstay of BU treatment an 8-week course rifampin (RIF) at 10 mg/kg body weight 150 streptomycin (STR). Recently, the injectable STR has been shown to be replaceable oral clarithromycin (CLR) for smaller lesions last 4 weeks treatment. A shorter, all-oral, highly efficient regimen needed, as long duration indirect costs currently...
Background Buruli ulcer is a stigmatising disease treated with antibiotics and wound care, sometimes surgical intervention necessary. Permanent limitations in daily activities are common long term consequence. It unknown to what extent patients perceive problems participation social activities. The psychometric properties of the Participation Scale used other disabling diseases, such as leprosy, was assessed for use former patients. Methods Former Ghana Benin, their relatives, healthy...
Buruli ulcer (BU) is a neglected tropical disease caused by infection with Mycobacterium ulcerans . Unclear transmission, no available vaccine, and suboptimal treatment regimens hamper the control of this disease. Carefully designed preclinical research needed to address these shortcomings. In vivo imaging (IVIS ® , Perkin Elmer, Waltham, MA) an emerging tool that permits monitoring progression reduces need using large numbers mice at different time-points during experiment, as individual...
Telacebec (Q203) is a new antituberculosis drug in clinical development that has extremely potent activity against Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU). The potency Q203 prompted investigation its potential role ultrashort, even single-dose, treatment regimens for BU mouse models. However, relationships dose, dose schedule, duration, and host immune status to outcomes remain unclear, as does risk emergence resistance with monotherapy. Here, we used footpad...
Rifampin (RIF) plus clarithromycin (CLR) for 8 weeks is now the standard of care Buruli ulcer (BU) treatment, but CLR may not be an ideal companion rifamycins due to bidirectional drug-drug interactions. The oxazolidinone linezolid (LZD) was previously shown active against Mycobacterium ulcerans infection in mice has dose- and duration-dependent toxicity humans. Sutezolid (SZD) tedizolid (TZD) safer than LZD. Here, we evaluated efficacy these oxazolidinones combination with rifampin a murine...
Treatment of mycobacterial diseases such as tuberculosis (TB) entails long and intense antimicrobial therapy. TB patients are at risk coinfection with other multidrug-resistant bacteria, those from Enterobacteriaceae family, because selection pressure nosocomial transmission during prolonged hospital admission. Here, we report on two treated for TB, who developed severe sepsis due to an extended spectrum β-lactamase producing organism. Diagnostic culture identified the venous access port...
Neopterin is closely associated with activation of the cellular immune system. levels differed between controls and patients Buruli ulcer disease. No differences or without paradoxical responses were observed. Therefore, neopterin has no value in detecting among limited lower receiving clarithromycin. This finding might indicate a slower recovery, possible consequences future therapy
Introduction Lassa fever (LF) is a severe and often fatal systemic disease in humans affects large number of countries West Africa. Treatment options are limited to supportive care the broad-spectrum antiviral agent ribavirin. However, evidence for ribavirin efficacy patients with LF poor pharmacokinetic (PK) data not available. Irrua Specialist Teaching Hospital (ISTH) developed an intravenous regimen different WHO recommendation. Apart from lower total daily dose drug usually administered...
Abstract Addressing the transmission enigma of neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring causative agent, Mycobacterium ulcerans , and BU. Here tested contaminated skin model BU by dipping tails from healthy mice in cultures . Tails were exposed to mosquito ( Aedes notoscriptus aegypti ) blood feeding or punctured with sterile needles. Two 11 M. A. developed Eighteen 20 subjected...
Lassa fever is a viral hemorrhagic treated with supportive care and the broad-spectrum antiviral drug ribavirin. The pathophysiology, especially role of hyperinflammation, this disease unknown. We report successful remission complicated in 2 patients Nigeria who received antiinflammatory agent dexamethasone standard
Electroencephalography (EEG) has been used for almost a century in well-equipped medical centers to facilitate the diagnosis of epilepsy and other brain disorders. Lassa fever (LF) emerging viral infections (EVI) are known cause neurological complications, including meningitis, seizures, encephalopathy, though date it remains unclear whether these secondary metabolic disturbances caused by disease or direct involvement central nervous system (CNS). To better characterize how virus (LASV)...