A5032408957- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
Universität Hamburg
2022-2024
University Medical Center Hamburg-Eppendorf
2022-2024
Potential differences in the breadth, distribution and magnitude of CD4
The nonstructural protein 12 (NSP12) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has a high sequence identity with common cold coronaviruses (CCC). Here, we comprehensively assessed breadth and specificity NSP12-specific T-cell response after in vitro expansion 185 overlapping 15-mer peptides covering entire SARS-CoV-2 NSP12 at single-peptide resolution cohort 27 disease 2019 (COVID-19) patients. Samples nine uninfected seronegative individuals, as well five...
Here, we longitudinally assessed the ex vivo frequency and phenotype of SARS-CoV-2 membrane protein (aa145-164) epitope-specific CD4+ T-cells an anti-CD20-treated patient with prolonged viral positivity in direct comparison to immunocompetent through MHC class II DRB1*11:01 Tetramer analysis. We detected a high stable membrane-specific T-cell response both patients, higher frequencies virus-specific B-cell-depleted patient. However, found altered memory that was skewed towards late...
Background: Chronic HCV infection leads to a complex interplay with adaptive immune cells that may result in B cell dyscrasias like cryoglobulinemia or lymphoma. While direct-acting antiviral therapy has decreased the incidence of severe liver damage, its effect on extrahepatic manifestations such as is still unclear. Methods: We sequenced receptor (BCR) repertoires patients chronic mono-infection and sustained virological response (SVR) after therapy. This data set was mined for highly...
Abstract Chronic hepatitis C virus (HCV) infection leads to a complex interplay with adaptive immune cells that may result in cryoglobulinemia or lymphoma. Although direct-acting antiviral (DAA) therapy has decreased the incidence of severe liver damage, its effect on extrahepatic HCV manifestations such as B cell dyscrasias is still unclear. Here, we used immunosequencing analyze imprinting receptor (BCR) repertoires patients chronic mono-infection sustained virological response (SVR) after...