A5002732213- Eating Disorders and Behaviors
- Regulation of Appetite and Obesity
- Obsessive-Compulsive Spectrum Disorders
- Obesity, Physical Activity, Diet
- Eicosanoids and Hypertension Pharmacology
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Hemoglobinopathies and Related Disorders
- Psychology Research and Bibliometrics
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- Adipose Tissue and Metabolism
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Cognitive and psychological constructs research
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Child and Adolescent Psychosocial and Emotional Development
- Impact of Technology on Adolescents
- Stress and Burnout Research
- Hormonal Regulation and Hypertension
- Bipolar Disorder and Treatment
- Alcohol Consumption and Health Effects
- Iron Metabolism and Disorders
Universidad de Extremadura
2014-2025
Hospital Universitario La Paz
2024
Hospital General Universitario De Valencia
2017-2018
Pontificia Universidad Católica de Chile
2012-2014
Clínica CES
2011
Nova Southeastern University
2011
Universidad CES
2011
Abstract Introduction TFAP 2B and KCTD 15 are obesity‐related genes that interact to regulate feeding behavior. We hypothesize variability in these loci, isolated or combination, could also be related the risk of eating disorders ( ED ) and/or associated psychological traits. Methods screened 425 participants (169 patients, 75 obese subjects, 181 controls) for 10 clinically relevant tag single‐nucleotide polymorphisms SNP s) by Sequenom Mass ARRAY platform direct sequencing. Psychometric...
Aim Post-transplant diabetes mellitus (PTDM) is one of the main complications after kidney transplantation. It known that leptin plays an important role in glucose metabolism and mutations receptor gene (LEPR) are responsible for different renal transplant recipients. We aimed to analyse association polymorphisms LEPR with development PTDM these patients.Methods A total 315 recipients were genotyped Lys109Arg, Gln223Arg Lys656Asn polymorphisms. The impact genetic variables together other...
Preclinical studies indicate that arachidonic acid (AA)-derived eicosanoids contribute to hyperglycemia-induced kidney injury. We aimed determine whether plasma and/or urinary levels of dihydroxyeicosatrienoic (DHETs) and 20-hydroxyeicosatetraenoic (20-HETE) acids are associated with diabetic disease (DKD). A total 334 subjects (132 DKD patients 202 non-diabetic individuals) were studied. Plasma 11,12-DHET, 14,15-DHET 20-HETE measured by LC/MS/MS. Urinary concentrations determined...
Objectives: This study aimed to investigate whether genetic variations in the OPRD1 gene affect psychopathological symptoms and personality dimensions eating disorders (ED) patients and/or contribute ED risk. Methods: The involved 221 female with anorexia nervosa (AN), 88 bulimia (BN) 396 controls. Sixteen tag-SNPs were identified. Psychometric evalu-ations conducted using Symptom Checklist 90 Revised (SCL-90R) Eating Dis-orders Inventory Test-2 (EDI-2). P-values obtained by regression...
Background: Dopamine physiological functions make dopaminergic genes suitable candidates for association studies in eating disorders (ED). A Val158Met polymorphism the catechol-O-methyltransferase (COMT) gene, which is involved dopamine degradation, has been studied relation to ED. Objective: We aimed analyze between this and general psychopathological symptoms that are often coupled these disorders. Method: total of 303 ED patients, diagnosed according DSM-5 criteria, completed SCL-90R...
Genes in the epoxygenase pathway of arachidonic acid metabolism leading to vasoactive eicosanoids, mainly 20-hydroxyeicosatetraenoic (20-HETE) and epoxyeicosatrienoic (EETs) acids, have been related glucose-induced renal damage preclinical reports. We genotyped 1088 diabetic kidney disease (DKD) patients controls for seven polymorphisms five genes (CYP2C8, CYP2J2, CYP4F2, CYP4A11, EPHX2) along this metabolic route evaluated their effect on DKD risk, clinical outcomes, plasma/urine levels...
Background Diabetic nephropathy (DN) has become the major cause of end-stage kidney disease and is associated to an extremely high cardiovascular (CV) risk.Methods We screened 318 DN patients for 23 SNPs in four glucose transporters (SLC2A1, SLC2A2, SLC5A1 SLC5A2) KCNJ11 ABCC8, which participate insulin secretion. Regression models were utilised identify associations with renal parameters, atherosclerosis measurements CV events. In addition, 506 individuals normal function also genotyped as...
The goal of this study was to detect the risk factors for adherence psychotherapy in patients with anxiety disorders. sample consists 188 subjects who entered Anxiety Disorders Program a mental health center Santiago, Chile during 2005-2009 period. variables examined were sex, socioeconomic status (SES), initial level according Hamilton Scale, comorbidity depressive disorder, presence pharmacological co-therapy, existence prior treatments, absences from therapeutic sessions and without...
We aimed to examine whether combined donor/recipient variants in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes may affect outcomes renal transplantation. A total of 233 donors their corresponding 307 recipients were genotyped for LEPR rs1805094, rs1137100 rs1137101, ADIPOQ rs1501299 rs224176. Combined genetic scores created investigate associations with delayed graft function (DGF), loss estimated glomerular filtration rate (eGFR). Recipients whose carried variant alleles...
There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 end-stage (ESKD) and 264 controls] were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) to determine metabolic profile 28 amino acids (AAs) biogenic amines test their value as markers CKD risk progression. The kynurenine/tryptophan ratio showed the strongest correlation estimated glomerular filtration rate values (coefficient =...
Cytochrome P450 (CYP) enzymes metabolize arachidonic acid to vasoactive eicosanoids such as epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic (20-HETE), whilst soluble epoxide hydrolase, encoded by the EPHX2 gene, is in charge of EETs degradation. We aimed analyze influence common, functional polymorphisms four genes donor on renal biopsy scores independently assigned pathologists. Additionally, we examined whether this score or presence these SNPs were independent risk factors...
Prostaglandin E2 (PGE2) is a major actor mediating renal injury. We aimed to determine genetic variability in the genes coding for its receptors (PTGER1-4) and study associations with nephrosclerosis risk clinical outcomes. identified 96 tag-SNPs capturing global PTGER1-4 screened 1209 patients controls. The effect of these variants was evaluated by multivariate regression analyses. Two PTGER3 SNPs, rs11209730 rs10399704, remained significant backward elimination model other non-genetic...
Nephrosclerosis patients have a high cardiovascular (CV) risk that is very often of more concern than the renal disease itself. We aimed to determine whether variants in phospholipase-related genes, associated with atherosclerosis and CV outcomes general population, could constitute biomarkers nephrosclerosis and/or its risk. screened 1,209 controls for 86 tag-SNPs were identified SCARB1, PLA2G4A, PLA2G7 gene loci. Regression models utilized evaluate their effect on several clinical...
Diabetic kidney disease (DKD) has been pointed out as a prominent cause of chronic and end-stage renal (ESRD). There is genetic predisposition to DKD, although clinically relevant loci are yet be identified. We utilized custom target next-generation sequencing 70-gene panel screen discovery cohort 150 controls, DKD DKD-ESRD patients. Relevant SNPs for the susceptibility clinical evolution were replicated in an independent validation 824 controls A network analysis aiming assess impact...
: This study aimed to investigate whether genetic variations in the