A5056300578- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Gas Sensing Nanomaterials and Sensors
- Microfluidic and Bio-sensing Technologies
- Nanoplatforms for cancer theranostics
- EEG and Brain-Computer Interfaces
- Electrocatalysts for Energy Conversion
- Photodynamic Therapy Research Studies
- Fuel Cells and Related Materials
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- bioluminescence and chemiluminescence research
- CO2 Reduction Techniques and Catalysts
- Advanced Photocatalysis Techniques
- Muscle activation and electromyography studies
- Pesticide and Herbicide Environmental Studies
University of Freiburg
2016-2025
Bernstein Center for Computational Neuroscience Freiburg
2018-2023
Brain (Germany)
2018-2023
Sensors (United States)
2014-2019
ETH Zurich
2016
EarthTech International (United States)
2009
We present a novel, multiparametric microphysiometry system for the dynamic online monitoring of human cancer cell metabolism. The optically transparent, modular, hybrid microsystem is based on glass chip and combines cultivation chamber, microfluidics metabolic with fully integrated chemo- biosensors. pH oxygen are measured in culture area, biosensors lactate glucose connected downstream by microfluidics. wafer-level fabrication features thin-film platinum iridium oxide microelectrodes...
An organ-on-chip platform equipped with microsensors for long-term microfluidic cultivation and metabolic monitoring (O 2 , Glu, Lac) of 3D tumour organoid cultures grown from patient-derived single cancer stem cells.
This article describes the electrochemical phenomena occurring at nanostructured platinum electrodes with high electrochemically active surface areas.
The excessive use of antibiotics in human and veterinary medicine causes the emergence multidrug resistant bacteria. In this context, surveillance many different provokes a worldwide challenge. Hence, fast versatile multianalyte single-use biosensors are increasing interest for fields such as medical analysis or environmental food control. Here we present microfluidic platform enabling electrochemical readout up to eight enzyme-linked assays (ELAs), simultaneously. To demonstrate...
Glyphosate (GLY) is a broad-spectrum herbicide and the most used pesticide worldwide. This vast usage has raised strong interest in ecotoxicological impacts human risks, with contamination of water being major concern. Decentralized analytical techniques for monitoring are high importance. In this work, we present small, low-cost, time-effective electrochemical, chip-based microfluidic device direct electrochemical detection GLY downstream molecularly imprinted polymer (MIP) concentrator. We...
The Sensing Cell Culture Flask (SCCF) is a cell culture monitoring system accessing the cellular microenvironment in 2D using electrochemical microsensors. based on microfabricated sensor chips embedded standard flasks. Ideally, could be equipped with any sensor. Its transparency allows optical inspection of cells during measurement. surface chip in-plane flask allowing undisturbed growth chip. A custom developed rack easy usage multiple flasks parallel within an incubator. presented data...
The limited performance of platinum-based electrocatalysts for glucose electrooxidation is a major concern fuel cells, since characterized by slow reaction kinetics and low diffusion coefficient. Here, the presented graphene-supported hierarchical nanostructures attain highly enhanced electrocatalytic activity towards oxidation. Platinum nanoparticles electrodeposited on graphene support retain mechanical stability act as junctions allowing reliable, smooth dense growth platinum nanowires...
Three-dimensional (3D) cell agglomerates, such as microtissues, organoids, and spheroids, become increasingly relevant in biomedicine. They can provide vitro models that recapitulate functions of the original tissue body have applications cancer research. For example, they are widely used organ-on-chip systems. Microsensors essential real-time information on metabolism well reliability quality culture conditions. The combination sensors 3D cultures, especially single is challenging terms...
Abstract Objectives Here we present an application, in two tumour cell lines, based on the Sensing Cell Culture Flask system as a culture monitoring tool for pericellular oxygen sensing. Materials and methods T‐47D (human breast cancer) T98G brain cells were cultured either atmospheric air or glove‐box set at 4% oxygen, both cases with 5% CO 2 gas phase. Pericellular tension was measured help of integrated sensor chip comprising arrays. Results Obtained results illustrate variation attached...
In this paper, we present a multiparametric microsensor platform for metabolic monitoring in vivo. contrast to silicon or ceramic-based systems, the flexible, implantable polymer-based sensor strip is manufactured cost-effective hybrid of thin-film and laminate technology wafer-level process. Flexibility allows easy handling placement soft tissue. It comprises microelectrode array up four electrochemical, amperometric micro-(bio)sensors, an integrated reference electrode. The energy...
Miniaturized and microstructured reactors in process engineering are essential for a more decentralized, flexible, sustainable, resilient chemical production. Modern, additive manufacturing methods metals enable complex reactor-geometries, increased functionality, faster design iterations, clear advantage over classical subtractive machining polymer-based approaches. Integrated microsensors allow online, situ monitoring to optimize processes like the direct synthesis of hydrogen peroxide. We...
Objective. The stability of platinum and other noble metal electrodes is critical for neural implants, electrochemical sensors, energy sources. Beyond the acidic or alkaline environment found in most studies, investigation electrode corrosion neutral pH chloride containing electrolytes essential, particularly regarding long-term interfaces, such as brain stimulation cochlear implants. In addition, increased use microfabricated devices demands thin-film combination with performance.Approach....