A5083075685- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Electrochemical sensors and biosensors
- Photonic and Optical Devices
- Electrochemical Analysis and Applications
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Diabetes Management and Research
- Acoustic Wave Resonator Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanofabrication and Lithography Techniques
- Mechanical and Optical Resonators
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mycotoxins in Agriculture and Food
- Force Microscopy Techniques and Applications
- Advanced Fiber Optic Sensors
- Semiconductor Lasers and Optical Devices
- Gas Sensing Nanomaterials and Sensors
- Indoor Air Quality and Microbial Exposure
- Biosimilars and Bioanalytical Methods
- Cardiovascular and exercise physiology
- Cancer, Hypoxia, and Metabolism
Jobst Technologies (Germany)
2015-2025
National Tsing Hua University
2009
TU Wien
1991-2005
Graz University of Technology
1996-2005
University of Freiburg
1998-2003
Ludwig Boltzmann Institute for Digital Health and Prevention
1990-1997
University of Applied Sciences Technikum Wien
1997
University of Vienna
1996
University of Kassel
1932
We present a novel, multiparametric microphysiometry system for the dynamic online monitoring of human cancer cell metabolism. The optically transparent, modular, hybrid microsystem is based on glass chip and combines cultivation chamber, microfluidics metabolic with fully integrated chemo- biosensors. pH oxygen are measured in culture area, biosensors lactate glucose connected downstream by microfluidics. wafer-level fabrication features thin-film platinum iridium oxide microelectrodes...
A complete Mach-Zehnder interferometer monolithically integrated on silicon is presented and employed as a refractive index bio-chemical sensor. The device consists of broad-band light sources optically coupled to photodetectors through monomodal waveguides forming arrays interferometers, all components being mainstream technology. photonically engineered in way that the phase difference travelling sensing reference arms approximately wavelength independent. Consequently, upon effective...
Broad-band Mach-Zehnder interferometry is analytically described and experimentally demonstrated as an analytical tool capable of high accuracy refractive index measurements over a wide spectral range. Suitable photonic engineering the interferometer sensing reference waveguides result in sinusoidal TE TM spectra with substantially different eigen-frequencies. This allows for instantaneous deconvolution multiplexed polarizations enables large shifts noise reduction through filtering Fourier...
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means photopatterning enzyme-containing photosensitive membrane precursors. This shows no cross-talk a lifetime both the sensors more than 2 weeks when continuously operated in undiluted bovine serum. Linear response ranges up to 40 mM 25 l-lactate, combination with 95% times <30 s, were realized. The devices are mass thin-film technology on flexible carriers give catheter-type multisensing vivo...
1IntroductionCell and gene therapies (CGTs) are new treatment modalities with demonstrated clinical results against a wide range of hard-to-treat diseases.[1, 2] They either ex vivo treatments, obtained by manipulating cells in laboratory before returning them to the patient, or applications, that involve direct injection genetic material into bloodstream target organ.[3] Cell therapy (CGT) products significantly different from previous generations biologics, such as recombinant proteins...
A silicon-based miniaturized sensor chip combined with an advanced microfluidic module for the simultaneous, label-free immunochemical determination of four allergens, bovine milk protein, peanut soy and gliadin, is presented. The consists array 10 broad-band Mach–Zehnder interferometers (BB-MZIs) monolithically integrated on silicon, along their respective light sources. BB-MZIs were biofunctionalized targeted allergens responses during immunoreaction monitored by multiplexing transmission...
The Sensing Cell Culture Flask (SCCF) is a cell culture monitoring system accessing the cellular microenvironment in 2D using electrochemical microsensors. based on microfabricated sensor chips embedded standard flasks. Ideally, could be equipped with any sensor. Its transparency allows optical inspection of cells during measurement. surface chip in-plane flask allowing undisturbed growth chip. A custom developed rack easy usage multiple flasks parallel within an incubator. presented data...
Abstract Protein detection and characterization based on Broad-band Mach-Zehnder Interferometry is analytically outlined demonstrated through a monolithic silicon microphotonic transducer. Arrays of light emitting diodes monomodal nitride waveguides forming interferometers were integrated chip. enters the exits sinusoidally modulated with two distinct spectral frequencies characteristic polarizations. Deconvolution in Fourier transform domain makes possible separation polarizations...
A prototype miniaturized Total Chemical Analysis System (μTAS) has been developed and applied to on-line monitoring of glucose lactate in the core blood anaesthetized dogs. The system consists a highly efficient microdialysis sampling interface sited small-scale extracorporeal shunt circuit (‘MiniShunt’), silicon machined microflow manifold integrated biosensor array for detection with associated computer software analytical process control. During in-vivo testing device allowed real-time...