A5023196480- Advanced Biosensing Techniques and Applications
- Photonic and Optical Devices
- Biosensors and Analytical Detection
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Silicon and Solar Cell Technologies
- Nanofabrication and Lithography Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Semiconductor materials and interfaces
- Advancements in Semiconductor Devices and Circuit Design
- Force Microscopy Techniques and Applications
- Thin-Film Transistor Technologies
- Mycotoxins in Agriculture and Food
- Semiconductor materials and devices
- Mechanical and Optical Resonators
- Advanced Fiber Optic Sensors
- Particle Detector Development and Performance
- Identification and Quantification in Food
- Advanced Semiconductor Detectors and Materials
- Monoclonal and Polyclonal Antibodies Research
- Molecular Junctions and Nanostructures
- Silicon Nanostructures and Photoluminescence
- Acoustic Wave Resonator Technologies
- Electrowetting and Microfluidic Technologies
- Nanowire Synthesis and Applications
National Centre of Scientific Research "Demokritos"
2015-2025
Fraunhofer Institute for Biomedical Engineering
2004
Syngenta (United Kingdom)
2002
National and Kapodistrian University of Athens
2002
University of Florida
1985-1990
California Institute of Technology
1986
A low cost, temperature process for sealing microfluidic devices composed of at least one organic polymeric substrate is presented. The based on the surface modification by means a silane solution, resulting in irreversible bonding. It generic method bonding polymeric/plastic substrates, bare or structured ones, such as poly(methylmethacrylate) (PMMA), polystyrene (PS) epoxy-type polymers, to Si-containing poly(dimethylsiloxane) (PDMS), Si and glass. In case that between polymer (PMMA, PS,...
The intrinsic carrier density in silicon has been measured by a novel technique based on low-frequency capacitance measurements of p+-i-n+ diode biased high injection. major advantage the method is its insensitivity to uncertainties regarding exact values mobilities, recombination parameters, and doping density. was temperature range from 78 340 K. At 300 K value ni found be (9.7±0.1)×109 cm−3.
A complete Mach-Zehnder interferometer monolithically integrated on silicon is presented and employed as a refractive index bio-chemical sensor. The device consists of broad-band light sources optically coupled to photodetectors through monomodal waveguides forming arrays interferometers, all components being mainstream technology. photonically engineered in way that the phase difference travelling sensing reference arms approximately wavelength independent. Consequently, upon effective...
Broad-band Mach-Zehnder interferometry is analytically described and experimentally demonstrated as an analytical tool capable of high accuracy refractive index measurements over a wide spectral range. Suitable photonic engineering the interferometer sensing reference waveguides result in sinusoidal TE TM spectra with substantially different eigen-frequencies. This allows for instantaneous deconvolution multiplexed polarizations enables large shifts noise reduction through filtering Fourier...
An optical real-time affinity biosensor, which is based on a monolithic silicon optoelectronic transducer and microfluidic module, described. The monolithically integrates avalanche diodes as light sources, nitride fibers, p/n junction detectors efficiently intercouples these elements through self-alignment technique. surface hydrophilized by oxygen plasma treatment, silanized with (3-aminopropyl)triethoxysilane bioactivated adsorption of the biomolecular probes. use module allows monitoring...
Aflatoxin M1 (AFM1) appears in the milk of animals that have consumed feed contaminated with aflatoxin B1. AFM1 presence is regulated by European Commission, which has set maximum allowable limits for adult and infant consumption to 50 25 pg/mL, respectively. Here, a rapid sensitive method detecting based on an immersible silicon photonic chip presented. The features two U-shaped nitride waveguides formed as Mach–Zehnder interferometers. One interferometer functionalized AFM1–bovine serum...
Integrated Optical Frequency-Resolved Mach-Zehnder Interferometry (IO FR-MZI) is introduced as an alternative, cost-efficient operation principle for integrated optical label-free affinity sensors that can combine high sensitivity with versatility in terms of potential applications and experimental configurations. A detailed theoretical analysis the method presented followed by a semi-analytical approximation numerical calculations order to quantify limits detection FR-MZI over Single...
A silicon-based miniaturized sensor chip combined with an advanced microfluidic module for the simultaneous, label-free immunochemical determination of four allergens, bovine milk protein, peanut soy and gliadin, is presented. The consists array 10 broad-band Mach–Zehnder interferometers (BB-MZIs) monolithically integrated on silicon, along their respective light sources. BB-MZIs were biofunctionalized targeted allergens responses during immunoreaction monitored by multiplexing transmission...
The consumption of water and milk contaminated with bacteria can lead to foodborne disease outbreaks. For this reason, the development rapid sensitive analytical methods for detection is primary importance public health protection. Here, a miniaturized immunosensor based on broadband Mach-Zehnder Interferometry simultaneous determination S. typhimurium E. coli O157:H7 in drinking presented. assay, mixtures solutions anti-bacteria-specific antibodies were run over chip, followed by...
The development of a four-band capillary optical immunosensor for the simultaneous determination mesotrione, hexaconazole, paraquat, and diquat is described. Four distinct bands (each corresponding to different analyte) are created in internal walls plastic by immobilizing protein conjugates analytes. To perform assay, filled with mixture anti-analyte-specific antibodies together standard or sample containing analyte(s). After short incubation, appropriate second labeled fluorescein...
Abstract Protein detection and characterization based on Broad-band Mach-Zehnder Interferometry is analytically outlined demonstrated through a monolithic silicon microphotonic transducer. Arrays of light emitting diodes monomodal nitride waveguides forming interferometers were integrated chip. enters the exits sinusoidally modulated with two distinct spectral frequencies characteristic polarizations. Deconvolution in Fourier transform domain makes possible separation polarizations...