A5038263055- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Marine Sponges and Natural Products
- Mitochondrial Function and Pathology
- Carbohydrate Chemistry and Synthesis
- 14-3-3 protein interactions
- Microbial Metabolic Engineering and Bioproduction
- Protein Tyrosine Phosphatases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
Charles River Laboratories (United States)
2021
Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, new phosphatase inhibitor classes are in high demand. The underlying frameworks of natural products represent the evolutionarily selected fractions space explored by nature so far meet criteria relevance to biological prevalidation most crucial development. We refer synthesis efforts compound collection development based on these biology-oriented synthesis. For...
Abstract Recently described rhizolutin and collinolactone isolated from Streptomyces Gö 40/10 share the same novel carbon scaffold. Analyses by NMR X‐Ray crystallography verify structure of propose a revision rhizolutin's stereochemistry. Isotope‐labeled precursor feeding shows that is biosynthesized via type I polyketide synthase with Baeyer–Villiger oxidation. CRISPR‐based genetic strategies led to identification biosynthetic gene cluster high‐production strain. Chemical semisyntheses...
Abstract Das kürzlich beschriebene Rhizolutin und Collinolacton, das aus Streptomyces Gö 40/10 isoliert wurde, besitzen dasselbe neuartige Kohlenstoffgerüst. Analysen mittels NMR Kristallstrukturanalyse belegen die Struktur von Collinolacton machen eine Korrektur der Stereochemie erforderlich. Fütterungsexperimente mit isotopenmarkierten Vorstufen zeigen, dass über Typ‐I‐Polyketidsynthase anschließender Baeyer‐Villiger‐Oxidation synthetisiert wird. CRISPR‐basierte genetische Arbeiten führten...