A5006894059- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Membrane Separation and Gas Transport
- Covalent Organic Framework Applications
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
- Liquid Crystal Research Advancements
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- RNA Interference and Gene Delivery
- Advanced MRI Techniques and Applications
- Click Chemistry and Applications
- Cellular transport and secretion
- Advanced Polymer Synthesis and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Photodynamic Therapy Research Studies
- Force Microscopy Techniques and Applications
- Advanced biosensing and bioanalysis techniques
CSIRO Manufacturing
2015-2024
RMIT University
2022-2024
Monash University
2010-2023
Commonwealth Scientific and Industrial Research Organisation
2010-2020
Health Sciences and Nutrition
2016
Materials Science & Engineering
2010-2015
Clayton Foundation
2015
NAACP Legal Defense and Educational Fund
2014
Australian Regenerative Medicine Institute
2014
Imperial College London
2001-2009
Abstract A bioactive synthetic porous shell was engineered to enable cells survive in an oligotrophic environment. Eukaryotic (yeast) were firstly coated with a β‐galactosidase (β‐gal), before crystallization of metal–organic framework (MOF) film on the enzyme coating; thereby producing shell. The β‐gal essential component as it generated nutrients (that is, glucose and galactose) required for cell viability nutrient‐deficient media (lactose‐based). Additionally, MOF coating carried out...
Nanostructured cubic lyotropic liquid crystalline colloidal particles (Cubosomes™) are of interest for applications such as drug and biomedical imaging agent encapsulation systems. Maintaining the stability integrity these nanoparticles over time is essential their storage application. It well known that triblock polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) copolymer, Pluronic F127, imparts a steric barrier to aggregation non-lamellar particles. However, few other...
In this paper, we give an overview of our studies by static and time-resolved X-ray diffraction inverse cubic phases phase transitions in lipids. §1 , briefly discuss the lyotropic behaviour lipids, focusing attention on non-lamellar structures, their geometric/topological relationship to fusion processes lipid membranes. Possible pathways for between different are also outlined. §2 effects hydrostatic pressure membranes transitions, describe how parameters required predict dependence...
Abstract Recent work in biomolecule‐metal–organic framework (MOF) composites has proven to be an effective strategy for the protection of proteins. However, other biomacromolecules such as nucleic acids, encapsulation into nano MOFs and related characterizations are their infancy. Herein, a complete gene‐set zeolitic imidazolate framework‐8 (ZIF‐8) cellular expression gene delivered by MOF reported. Using green fluorescent protein (GFP) plasmid (plGFP) proof‐of‐concept genetic macromolecule,...
The loss of internal pores, a process known as physical aging, inhibits the long-term use most promising gas-separation polymers. Previously we reported that porous aromatic framework (PAF-1) could form remarkable nanocomposite with polymers to stop aging. However, PAF-1 synthesis is very onerous both from reagent and reaction-condition perspective, making it difficult scale-up. We now reveal highly dispersible scalable additive based on α,α'-dichloro-p-xylene (p-DCX), aging more...
High-throughput methodologies have been employed to establish structure-property relationships and assess the effectiveness of nonionic steric stabilizers for inverse bicontinuous cubic lyotropic liquid crystalline nanoparticulate dispersions monoolein phytantriol. The ability disperse lipids was compared with that commonly triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) copolymer Pluronic F127, which used as a positive control. stearate class (commercially known...
Monoolein–capric acid combinations form into particles with internal nanostructures, including inverse hexagonal and bicontinuous cubic mesophases, differing cytotoxicity.
Lyotropic liquid crystalline nanoparticle dispersions are of interest as delivery vectors for biomedicine. Aqueous liposomes, cubosomes, and hexosomes commonly stabilized by nonionic amphiphilic block copolymers to prevent flocculation phase separation. Pluronic stabilizers such F127 used; however, there is increasing in using chemically reactive enhanced functionalization specificity therapeutic applications. This study has explored the ability...
Abstract Metal–organic frameworks (MOFs) exhibit large surface areas and low thermal conductivity, making them promising for thermoelectric generation. However, their limited electrical conductivity poses a significant hurdle to be practically useful. Traditionally, enhancing the of MOFs typically comes at cost reducing area, thereby increasing conductivity. This study introduces an approach simultaneously boost porosity MOF‐based material while maintaining remarkably The electrically...
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment PTEN results in antidiabetic impact, which led to the suggestion that could be target for drugs against type II diabetes. Here we report design validation small- molecule inhibitor PTEN. Compared with other cysteine-based phosphatases, has much wider active site cleft enabling it bind PtdIns(3,4,5)P3 substrate. We...
The liquid crystalline lamellar (${L}_{\ensuremath{\alpha}}$) to double-diamond inverse bicontinuous cubic (${Q}_{\mathrm{II}}^{D}$) phase transition for the amphiphile monoelaidin in excess water exhibits a remarkable sequence of structural transformations pressure or temperature jumps. Our data imply that dynamics depends on coupling between changes molecular shape and geometrical topological constraints domain size. We propose qualitative model this based theories membrane fusion via...
Biomimetic mineralization exploits natural biomineralization processes for the design and fabrication of synthetic functional materials.
Abstract The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half‐life in vivo. Thus there is a need for drug delivery system that acts as reservoir and releases the remotely “on demand”. Here we demonstrate simple light‐triggered local through photo‐thermal interactions polymer‐coated gold nanoparticles (AuNPs) inside an agarose hydrogel therapeutic depot. Localized temperature increase induced by visible...
Lyotropic liquid crystalline lipid nanoparticles demonstrate high bioconjugation efficiency with therapeutic antibody fragments for targeted drug delivery.
Membrane materials with high permeability to solvents while rejecting dissolved contaminants are crucial lowering the energy costs associated liquid separations. However, current lack of stable high-permeability require innovative engineering solutions yield high-performance, thin membranes using polymers low permeabilities. Poly[1-(trimethylsilyl)-1-propyne] (PTMSP) is one most permeable but extremely susceptible physical aging. Despite recent developments in anti-aging polymer membranes,...
Mesophase structures of self-assembled lyotropic liquid crystalline nanoparticles are important factors that directly influence their ability to encapsulate and release drugs biological activities. However, it is difficult predict precisely control the mesophase behavior these materials, especially in complex systems with several components. In this study, we report controlled manipulation monoolein (MO) phytantriol (PHYT) by adding unsaturated fatty acids (FAs). By using high throughput...
Abstract It is increasingly apparent that negative emissions technologies, such as direct air capture (DAC), are required part of the technology mix for limiting global atmospheric temperature increase. For all DAC requisite energy regeneration separation media strongly influences overall cost process and therefore directly their likely implementation. Herein, results a pilot‐scale demonstration new metal organic framework (MOF) based technology, Airthena, incorporated within mobile unit...
Combining the MOF biomimetic mineralisation of enzymes with electrochemical sensing, an ultra-stable proof-of-concept biosensor a clinically relevant wide linear range 1–10 mM glucose and detection limit 0.05 is fabricated.
The invaluable health, economic and social impacts of vaccination are hard to exaggerate. ability stabilize vaccines is urgently required for their equitable distribution without the dependence on 'cold-chain' logistics. Herein, first time we report biomimetic-mineralization live-viral using metal-organic frameworks (MOFs) enhance storage stability from days months. Applying ZIF-8 aluminium fumarate (Alfum), Newcastle Disease Virus (NDV) V4 strain Influenza A WSN were encapsulated with...