A5086075385- Polysaccharides and Plant Cell Walls
- Supramolecular Self-Assembly in Materials
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Lipid Membrane Structure and Behavior
- 3D Printing in Biomedical Research
- Corneal surgery and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Surfactants and Colloidal Systems
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Polydiacetylene-based materials and applications
- Plant Gene Expression Analysis
- Silk-based biomaterials and applications
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Corneal Surgery and Treatments
- Crystallization and Solubility Studies
- Multiple Sclerosis Research Studies
- Microbial infections and disease research
- X-ray Diffraction in Crystallography
Monash University
2025
La Trobe University
2020-2024
Agriculture and Food
2020-2024
AgriBio
2021-2024
CSIRO Manufacturing
2016-2023
Commonwealth Scientific and Industrial Research Organisation
2017-2019
Clayton Foundation
2016-2017
Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting drug and presence toxic solvents required dissolving PTX prior injection, there are several serious side effects associated with this treatment. In study, we explored self-assembled lipid-based nanoparticles carriers, which were able improve its antitumour efficacy against The also functionalized epidermal growth factor...
There is a dire need to develop more effective therapeutics combat brain cancer such as glioblastoma multiforme (GBM). An ideal treatment expected target deliver chemotherapeutics glioma cells across the blood-brain barrier (BBB). The overexpression of transferrin (Tf) receptor (TfR) on BBB and GBM cell surfaces but not surrounding renders TfR promising target. While porous silicon nanoparticles (pSiNPs) have been intensely studied delivery vehicle due their high biocompatibility,...
COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However, neurological symptoms such memory loss, sensory confusion, severe headaches, and even stroke are reported in up to 30% of cases can persist after the infection over (long COVID). These thought be produced virus infecting central nervous system, however we don't understand molecular mechanisms triggering them. The effects share similarities neurodegenerative diseases which presence cytotoxic aggregated amyloid...
Mesophase structures of self-assembled lyotropic liquid crystalline nanoparticles are important factors that directly influence their ability to encapsulate and release drugs biological activities. However, it is difficult predict precisely control the mesophase behavior these materials, especially in complex systems with several components. In this study, we report controlled manipulation monoolein (MO) phytantriol (PHYT) by adding unsaturated fatty acids (FAs). By using high throughput...
Secondary cell walls (SCWs) in stem xylem vessel and fibre cells enable plants to withstand the enormous compressive forces associated with upright growth. It remains unclear if can directly sense mechanical stimuli modify their SCW during development. We provide evidence that Arabidopsis SCW-specific Fasciclin-Like Arabinogalactan-proteins 11 (FLA11) 12 (FLA12) are possible surface sensors regulating development response stimuli. Plants overexpressing FLA11 (OE-FLA11) showed earlier...
Abstract The role of glycoproteins as key cell surface molecules during development and stress is well established; yet, the relationship between their structural features functional mechanisms poorly defined. FASCICLIN-LIKE ARABINOGALACTAN PROTEINs (FLAs), which impact plant growth development, are an excellent example a glycoprotein family with complex multidomain structure. FLAs combine globular fasciclin-like (FAS1) domains regions that intrinsically disordered contain glycomotifs for...
Abstract Using small angle neutron scattering (SANS), it is shown that the existence of pre-assembled structures at high pH for a capped diphenylalanine hydrogel controlled by selection N-terminal heterocyclic capping group, namely indole or carbazole. At pH, changing from somewhat hydrophilic group to more hydrophobic carbazole results in shift proportion monomers self-assembled fibers wormlike micelles. The presence these different confirmed through NMR and circular dichroism spectroscopy,...
Self-assembled lipid lyotropic liquid crystalline nanoparticles such as hexosomes and cubosomes contain internal anisotropic isotropic nanostructures, respectively. Despite the remarkable potential of in various biomedical applications, stabilisers used formulating are often limited to commercially available polymers Pluronic block copolymers. This study explored using Reversible Addition-Fragmentation chain Transfer (RAFT) technology design amphiphilic brush-type for purpose stabilising...
The predominant Fascilin 1 (FAS1)-containing proteins in plants belong to the Fasciclin-Like Arabinogalactan-protein (FLA) family of extracellular glycoproteins. In addition FAS1 domains, these multi-domain FLA contain glycomotif regions predicted direct large arabinogalactan (AG) glycans and many signal sequences for a glycosylphosphatidylinositol (GPI)-anchor tether them plasma membrane. FLAs are proposed play both structural signaling functions by forming range interactions plant matrix,...
Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show epithelium-specific deletion in adult mice leads to rapid fatal enteritis compromised gut barrier integrity, highlighting its intrinsic critical role maintenance. BECLIN1-deficient epithelial cells exhibit extensive apoptosis, impaired autophagy, stressed...
Abstract High‐performance proton exchange membranes (PEMs) play a vital role in the efficiency of high‐temperature membrane fuel cells. In this study, novel PEM with hyperbranched interpenetrating hydrogen bond network (HIHBN) is developed by incorporating poly(benzyl‐triptycene) (PBT) and SnP 2 O 7 networks. This innovative design significantly enhances conductivity. Additionally, unique structure PBT polymer branching point (triptycene, π‐conjugated aromatic ring compound three‐cyclic...
Novel X-ray crystal structures of cyclic <sc>d</sc>/<sc>l</sc> peptide nanotubes in antiparallel and parallel configurations.
The mechanical and architectural properties of the three-dimensional (3D) tissue microenvironment can have large impacts on cellular behavior phenotype, providing cells with specialized functions dependent their location. This is especially apparent in macrophage biology where function resident macrophages highly to 3D bioprinting provides a convenient method fabricating biomaterials that mimic specific architectures. If these printable materials also possess tunable properties, they would...
We report a novel cubosome formulation that is effective at killing <italic>Staphylococcus aureus in vitro</italic>.
Preformed amyloid seeds increase the stability and toxicity of peptide amyloids formed from viral proteins SARS-CoV-2, these protein may cause some neurological symptoms COVID-19.
The 5-hydroxytryptamine 3 (5-HT3) receptor belongs to the pentameric ligand-gated cation channel superfamily. Humans have five different 5-HT3 subunits: A E. receptors are located on cell membrane, but a previous study suggested that mitochondria could also contain subunits. In this article, we explored distribution of subunits in intracellular and cell-free mitochondria. Organelle prediction software supported localization E inner membrane We transiently transfected HEK293T cells do not...
Fullerenes are a class of carbon nanomaterials that find wide range applications in biomedical fields, especially for photodynamic cancer therapy because its photosensitive effect. However, hydrophobic fullerenes can only be dispersed organic solvents which hinders their applications. Here, we report facile method to prepare highly water-dispersible fullerene (C
Abstract Oat (Avena sativa) is a cereal crop whose grains are rich in (1,3;1,4)-β-D-glucan (mixed-linkage glucan or MLG), soluble dietary fiber. In our study, we analyzed oat endosperm development 2 Canadian varieties with differing MLG content and nutritional value. We confirmed that undergoes nuclear type of but shorter cellularization phase than barley (Hordeum vulgare). Callose cellulose were the first polysaccharides to be detected early anticlinal cell walls at 11 days postemergence...
The identification of practical early diagnostic biomarkers is a cornerstone improved prevention and treatment cancers. Such case devil facial tumor disease (DFTD), highly lethal transmissible cancer afflicting virtually an entire species, the Tasmanian ( Sarcophilus harrisii ). Despite latent period that can exceed one year, to date DFTD diagnosis requires visual lesions. To enable earlier diagnosis, which essential for implementation effective conservation strategies, we analyzed...
The Shorthead lamprey Mordacia mordax (Mordaciidae, Agnatha) represents one of the earliest stages vertebrate evolution. This study investigates ultrastructural anatomy cornea, iris and anterior chamber in eyes this species both downstream upstream migrant phases its protracted lifecycle to assess morphological quantitative changes associated with growth, corneal function vision. Using light scanning transmission electron microscopy, cornea is found be divided into dermal scleral components...
Wall-associated kinases/kinase-likes (WAKs/WAKLs) are plant cell surface sensors. A variety of studies have revealed the important functions WAKs/WAKLs in regulating expansion and defense cells with primary walls. Less is known about their roles during development secondary walls (SCWs) that present xylem vessel (XV) interfascicular fiber (IF) cells. In this study, we used RNA-seq data to screen Arabidopsis thaliana members may be involved SCW identified WAKL8 as a candidate. We obtained...