A5103282425- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
- Nanopore and Nanochannel Transport Studies
- Biochemical and Molecular Research
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Health Systems, Economic Evaluations, Quality of Life
- Glioma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Hepatitis B Virus Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Genital Health and Disease
- Advanced Breast Cancer Therapies
- Lipid Membrane Structure and Behavior
- Pancreatic and Hepatic Oncology Research
The University of Melbourne
2010-2021
Peter MacCallum Cancer Centre
2018-2021
The Royal Melbourne Hospital
2017-2021
RMIT University
2018-2020
Institute of Mental Health
2013
Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting drug and presence toxic solvents required dissolving PTX prior injection, there are several serious side effects associated with this treatment. In study, we explored self-assembled lipid-based nanoparticles carriers, which were able improve its antitumour efficacy against The also functionalized epidermal growth factor...
Cubosomes with an internal three-dimensional (3D) periodic and porous particulate nanostructure have emerged as a promising drug delivery system for hydrophobic small molecules well large biomolecules over the past several decades. Limited understanding of their safety profiles biodistribution, however, hinders clinical translation. This study used monoolein-based cubosomes stabilized by Pluronic F127 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] polymers...
Abstract Background Dialysis prolongs the life of people with end‐stage renal disease ( ESRD ), but for patients who are elderly and suffer multiple comorbid illnesses benefits dialysis may be outweighed by its negative consequences. Non‐dialytic conservative management has therefore become an alternative treatment route, yet little is known on patients' experience choosing end‐of‐life treatment. Aims To gain insight into decision‐making process leading to opting out non‐dialytic from...
Signal transducer and activator of transcription 3 (STAT3) signaling is a major driver colorectal cancer (CRC) growth, however therapeutics, which can effectively target this pathway, have so far remained elusive. Here, we performed an extensive screen for STAT3 inhibitors among library 1167 FDA-approved agents, identifying Ponatinib as lead candidate. We found that inhibits activity driven by EGF/EGFR, IL-6/IL-6R IL-11/IL-11R, three ligand/receptor systems involved in CRC development...
ABSTRACT Ets homologous factor (EHF) is a member of the epithelial-specific (ESE) family transcription factors. To investigate its role in development and epithelial homeostasis, we generated series novel mouse strains which DNA-binding domain Ehf was deleted all tissues (Ehf−/−) or specifically gut epithelium. Ehf−/− mice were born at expected Mendelian ratio, but showed reduced body weight gain, developed pathologies requiring most to reach an ethical endpoint before reaching 1 year age....
Cetuximab is a common treatment option for patients with wild-type K-Ras colorectal carcinoma. However, often display intrinsic resistance or acquire to cetuximab following treatment. Here we generate two human CRC cells acquired that are derived from cetuximab-sensitive parental cell lines. These cetuximab-resistant greater in vitro proliferation, colony formation and migration, vivo tumour growth compared their counterparts. To evaluate potential alternative therapeutics...
Background: Janus kinases (JAKs) are important regulators of intracellular responses triggered by many key proinflammatory cytokines and clinically validated therapeutic targets for treating various autoimmune diseases. However, current approved JAK inhibitors failed to achieve maximal clinical benefit in part due their unfavorable selectivity individual JAKs such as JAK2 and/or JAK3, leading dose-limiting toxicities or severe (e.g., thrombosis, anemia, immune suppression). Selective...
Introduction: Colorectal cancer (CRC) is the 4th most common globally. Despite, targeted agents producing advances in some CRC patients, tumour progression still frequently observed. Further research urgently needed to realise potential of therapies for CRC. A key transcription factor potentially target Signal Transducer and Activator Transcription 3 (STAT3). In over 50% human tissue, STAT3 hyper-activated, considerable evidence demonstrates that critical progression. Inhibiting therefore a...
Abstract Background Ets homologous factor (EHF) is a member of the epithelial-specific (ESE) transcription factors. EHF specifically expressed in epithelial tissues, however its role development and homeostasis largely uncharacterized. Methods We generated novel mouse strain which DNA binding domain (exon 8) Ehf was flanked by loxP sites ( Lox/Lox ). To inactivate whole body, mice were crossed to CMV Cre mice, then bred out generate germline null −/− ) mice. intestinal epithelium,...