A5031254728- Antimicrobial Peptides and Activities
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Calcium signaling and nucleotide metabolism
- Polydiacetylene-based materials and applications
- Organometallic Complex Synthesis and Catalysis
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- SARS-CoV-2 and COVID-19 Research
- Cell death mechanisms and regulation
- Synthetic Organic Chemistry Methods
- Invertebrate Immune Response Mechanisms
- Biochemical and Molecular Research
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Animal Virus Infections Studies
- Toxoplasma gondii Research Studies
- Biochemical and Structural Characterization
The University of Queensland
2025
La Trobe University
2019-2023
COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However, neurological symptoms such memory loss, sensory confusion, severe headaches, and even stroke are reported in up to 30% of cases can persist after the infection over (long COVID). These thought be produced virus infecting central nervous system, however we don't understand molecular mechanisms triggering them. The effects share similarities neurodegenerative diseases which presence cytotoxic aggregated amyloid...
The ongoing SARS-CoV-2 pandemic continues to be a major health burden globally, especially in resource-limited areas. Continued research into more effective and accessible vaccines is required reduce the of disease. Here, we use an emerging vaccine delivery system, high-density microarray patch (HD-MAP) deliver plasmid DNA (Delta 6P) encoding for spike protein. HD-MAP this resulted robust IgG responses mice against multiple domains cellular response vaccination was also measured, comparative...
Defensins form an integral part of the cationic host defence peptide (HDP) family, a key component innate immunity. Apart from their antimicrobial and immunomodulatory activities, many HDPs exert multifaceted effects on tumour cells, notably direct oncolysis and/or inhibition cell migration. Therefore, have been explored as promising anticancer therapeutics. Human β-defensin 2 (HBD-2) represents prominent member human HDPs, being well-characterised for its potent pathogen-killing,...
Abstract Crocodilians are an order of ancient reptiles that thrive in pathogen-rich environments. The ability to inhabit these harsh environments is indicative a resilient innate immune system. Defensins, family cysteine-rich cationic host defence peptides, major component the systems all plant and animal species, however crocodilian defensins poorly characterised. We now show saltwater crocodile defensin CpoBD13 harbors potent antifungal activity mediated by pH-dependent membrane-targeting...
A family of eight rhenium(I) tricarbonyl complexes bearing pyridyl-imidazolylidene or bis-imidazolylidene ligands in combination with a series N-acetyl amino acids (glycine, isoleucine, and proline) an acetate have been synthesised characterised. These are interest as potential anticancer agents, where the oxygen bound carboxylate ligand can exchange water giving rise to cytotoxic cationic complexes. The pseudo-first-order aquation rate constants for were evaluated using 1H NMR time-course...
Abstract COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, even stroke are reported in many 30% of cases can persist after infection over (so-called ‘long COVID’). These thought to be brain inflammation, infecting central nervous system patients, however we still don’t understand molecular mechanisms that trigger these symptoms. The...
ABSTRACT COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, even stroke are reported in many 30% of cases can persist after infection over (so-called ‘long COVID’). These thought to be brain inflammation, triggered infecting central nervous system patients, however we still don’t fully understand mechanisms for these symptoms. The effects...
Crocodilians are an order of ancient reptiles that thrive in pathogen-rich environments.The ability to inhabit these harsh environments is indicative a resilient innate immune system.Defensins, family cysteine-rich cationic host defence peptides, major component the systems all plant and animal species, however crocodilian defensins poorly characterised.We now show saltwater crocodile defensin CpoBD13 harbors potent antifungal activity mediated by novel pH-dependent membrane-targeting...