A5053005771- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Fetal and Pediatric Neurological Disorders
- Intestinal and Peritoneal Adhesions
- Genomic variations and chromosomal abnormalities
- Hernia repair and management
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Homicide, Infanticide, and Child Abuse
- Congenital Anomalies and Fetal Surgery
- Gestational Diabetes Research and Management
- Parvovirus B19 Infection Studies
- Folate and B Vitamins Research
- Family Dynamics and Relationships
- Metabolism and Genetic Disorders
- Minimally Invasive Surgical Techniques
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Healthcare Systems and Challenges
- Biotechnology and Related Fields
- Reproductive Health and Contraception
- Prenatal Substance Exposure Effects
- Congenital heart defects research
- Genetics, Bioinformatics, and Biomedical Research
- Sarcoidosis and Beryllium Toxicity Research
Birmingham Women’s and Children’s NHS Foundation Trust
2014-2024
Worcestershire Acute Hospitals NHS Trust
2021
University of Birmingham
2014-2020
Pennine Acute Hospitals NHS Trust
2006-2020
Birmingham Women's Hospital
2014-2018
Max Planck Institute for Metabolism Research
2014-2018
The University of Texas Medical Branch at Galveston
2018
Womens Foundation
2015
Royal Oldham Hospital
2012
University of Manchester
2009
Purpose To describe and classify the range of brain injuries present at prenatal, in-utero magnetic resonance (MR) imaging in co-twin survivors monochorionic (MC) twin pregnancies complicated by single intrauterine death (SIUD). Materials Methods This retrospective, observational study from six tertiary fetal medicine centers that perform tertiary-level prenatal MR studies reviewed cases which had shown a injury surviving pregnancy with MC component SIUD. Results Forty-two twins were...
Low maternal folate status during pregnancy increases the risk of delivering small for gestational age (SGA) infants, but mechanistic link between status, SGA, and placental dysfunction is unknown. microRNAs (miRNAs) are altered in pathologies by other systems. We hypothesized that low causes dysfunction, mediated miRNA expression.A prospective observational study recruited pregnant adolescents assessed third trimester function. array, QPCR, bioinformatics identified miRNAs target genes....
Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion syndrome (TTTS) which affects 10–15% monochorionic twins, if untreated has 70–90% perinatal loss rate. We currently unable predict twins will develop or what severity. have previously shown differences in angiogenic placental growth factors maternal blood complicated by TTTS compared not...
Objective Report maternal, fetal and neonatal complications associated with single intrauterine death (sIUFD) in monochorionic twin pregnancies. Design Prospective observational study. Setting UK. Population 81 pregnancies sIUFD after 14 weeks gestation, irrespective of cause. Methods UKOSS reporters submitted data collection forms using from hospital records. Main outcome measures Aetiology sIUFD; surviving co-twin outcomes: perinatal mortality, central nervous system (CNS) imaging,...
<b><i>Introduction:</i></b> Fetal anemia can have significant perinatal morbidity and mortality, particularly with onset prior to 20 weeks of gestation. <b><i>Materials Methods:</i></b> We detail a case-cohort study (n = 8) all women who underwent fetal in-utero, intracardiac transfusion 24 gestation (7 before + 1 weeks), between March 2004 September 2014, in supraregional Medicine Center the United Kingdom, comprising 2.2% transfusions...
Monochorionic twin pregnancies are at high risk of adverse outcomes, but it is not possible to predict which will develop complications. The aim the study was evaluate, in monochorionic pregnancies, whether first-trimester ultrasound (nuchal translucency [NT], crown-rump length [CRL]), and maternal serum biomarkers (alpha-fetoprotein [AFP], soluble fms-like tyrosine kinase-1 [sFlt-1] placental growth factor [PlGF]), prognostic factors for fetal outcome composite, twin-twin transfusion...
Abstract Background Twin-twin transfusion syndrome (TTTS) is a highly morbid condition in which treatment exists, but the pregnancy remains high-risk until delivery. It may have serious sequelae, including fetal death, and longer term, neurodevelopmental problems. The aim of this study to assess antenatal postnatal parental attachment depressive symptoms those with pregnancies affected by TTTS. Methods Couples attending for fetoscopic laser ablation TTTS were asked complete Condon’s...
Key content Noninvasive prenatal testing (NIPT) uses cell‐free fetal DNA (cffDNA) to test for aneuploidy, as opposed noninvasive diagnosis (NIPD), which cffDNA diagnose sex, Rhesus D status and monogenic disorders. This classic review focuses on screening aneuploidy. NIPT is a needs confirmatory invasive in cases of high‐risk (positive) result. demonstrates high sensitivities specificities according our recent meta‐analysis, although it less accurate Trisomy 18, 13, Monosomy X sex...
Key content: Sarcoidosis is an uncommon multi‐system disorder characterised by the presence of non‐caseating granulomas. It has a peak incidence between ages 20–40 years old. The pathogenesis sarcoidosis uncertain; however, it known to be associated with exaggerated T helper 1 (T H 1) immune response leading systemic inflammation and granuloma formation. Suppression in responses pregnancy leads disease remission majority pregnancies. Nevertheless, potential for decompensation subgroup...
MicroRNAs (miRNAs) are used as biomarkers in cardiovascular disease and cancer. miRNAs involved placental development but have not previously been investigated twin-twin transfusion syndrome (TTTS). Our aim is to explore the miRNA profile of TTTS pregnancies.
Aims and Method Electroconvulsive therapy should be effectively monitored seizure duration accurately ascertained. We observed the in both lower upper limbs using Hamilton ‘cuff’ method. Results Thirty-nine seizures 19 patients were observed. There no statistically significant differences between cuffed uncuffed limbs, nor limbs. Clinical Implications Alternatives to cuff method observe need considered.