A5087919323- Redox biology and oxidative stress
- Metal-Catalyzed Oxygenation Mechanisms
- S100 Proteins and Annexins
- Enzyme Catalysis and Immobilization
- Polyamine Metabolism and Applications
- Connexins and lens biology
- Amino Acid Enzymes and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2018-2024
Reactive oxygen species (ROS), play important roles in cellular signaling, nonetheless are toxic at higher concentrations. Cells have many interconnected, overlapped or backup systems to neutralize ROS, but their regulatory mechanisms remain poorly understood. Here, we reveal an essential role for mitochondrial AMPylase Fmp40 from budding yeast regulating the redox states of 1-Cys peroxiredoxin Prx1, which is only protein shown H
Abstract Reactive oxygen species (ROS), play important roles in cellular signaling, nonetheless are toxic at higher concentrations. Cells have many interconnected, overlapped or backup systems to neutralize ROS, but their regulatory mechanisms remain poorly understood. Here, we reveal an essential role for mitochondrial AMPylase Fmp40 from budding yeast regulating the redox states of 1-Cys peroxiredoxin, Prx1, which is only protein shown H 2 O with oxidation glutathione and Trx3,...
<p>AMPylation (adenylation) is one of the post-translational protein modifications (PTM) leading to diversification functions and activity. With our collaborators, we discovered that SelO family members humans, yeast, E. coli have AMPylase The yeast – Fmp40 was identified in proteome inter-membrane space mitochondria. We shown involved response cells hydrogen peroxide (H2O2) menadione treatment: lacking grow sensitivity upon H2O2 treatment. AMPylates glutaredoxin...