A5080932420- Glycosylation and Glycoproteins Research
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Acute Lymphoblastic Leukemia research
- Toxin Mechanisms and Immunotoxins
- Erythrocyte Function and Pathophysiology
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Carbohydrate Chemistry and Synthesis
- Phytochemicals and Medicinal Plants
- Protein purification and stability
- Bioactive Compounds and Antitumor Agents
- Cell death mechanisms and regulation
- Invertebrate Immune Response Mechanisms
- Parasites and Host Interactions
- Lung Cancer Research Studies
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Malaria Research and Control
- Genomics, phytochemicals, and oxidative stress
- T-cell and B-cell Immunology
Council of Scientific and Industrial Research
2015-2025
Indian Institute of Chemical Biology
2016-2025
Diamond Harbour Women's University
2023
Defence Metallurgical Research Laboratory
2023
Indian Institute of Technology Madras
2019-2022
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2012
Vidyasagar University
2012
University of Gour Banga
2012
In-Q-Tel
2012
Indian Institute of Tropical Meteorology
2009
PA is an opportunistic pathogen that commonly associated with severe infection in immunocompromised hosts. Siglec-9 binds Sias by cis interaction on the neutrophil surface, thereby reducing immunological activity. However, neutrophils bind pathogens through trans interactions of siglec-9 Sias. Neutrophils kill invading NETs, along extracellular phagocytosis. Here, we report mode adsorption from host serum, PA(+Sias) human neutrophils, and resulting The α2-3-linked sialoglycoproteins adsorbed...
Ceramide is an important second messenger that has diverse cellular and biological effect. It a specific potent inducer of apoptosis suppressor cell growth. In leukemia, chemoresistance generally developed due to deregulated ceramide metabolism. combinatorial treatment strategies few components have the capability increases production. Manipulation in production by physiological pharmacological modulators therefore will give additive effect leukemia chemotherapy.Here, we show Withanolide D...
Abstract Cancer cells display abnormal redox metabolism. Autophagy, anoikis and reactive oxygen species (ROS) play a regulatory role during metastasis. LC3 is well-known essential molecule for autophagy. Therefore, we wanted to explore the molecular interplay between autophagy, anoikis, ROS in relation LC3B. We observed enhanced LC3B level along with increased expression of p62 modulation other autophagy-related molecules (Atg 3, 5, 7, 12, 16L1 Beclin1) by inducing oxidative-stress ovarian...
With an aim to overcome multidrug resistance (MDR), nontargeted delivery, and drug toxicity, we developed a new nanochemotherapeutic system with tetrasodium salt of meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) armored on gold nanoparticles (TPPS-AuNPs). The nanocarrier is able be selectively internalized within tumor cells than in normal followed by endocytosis therefore delivers the antitumor doxorubicin (DOX) particularly nucleus diseased cells. embedment TPPS nanosurface provides...
Leishmaniasis remains a major health problem of the tropical and subtropical world. The visceral form causes most fatalities if left untreated. Dramatic increases in rates infection drug resistance non-availability safe vaccines have highlighted need for identification novel inexpensive anti-leishmanial agents. This study reports that racemoside A, water-soluble steroidal saponin purified from fruits Asparagus racemosus , is potent molecule effective against antimonial-sensitive (strain...
The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role sialic acids (Sia) this phenomenon. Culture PA presence exogenous Sia resulted linkage‐specific incorporation which was associated with decreased complement deposition on bacteria. acquired by mediated enhanced binding bacteria recombinant‐CHO cells expressing human siglec‐7 or siglec‐9, as well NK‐cells and monocytes naturally these siglecs. Therefore, may be host contribute...
Abstract Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated oxidative stress‐mediated dysfunction Hsp90 hindrance chaperonic activity carbazole alkaloid, mahanine, as strategic pancreatic cancer. Mahanine exhibited antiproliferative against several cell lines through apoptosis. It induced early...
Effects of strontium and lithium ion doping on the biological properties bioactive glass (BAG) porous scaffolds have been checked in vitro vivo. BAG were prepared by conventional melting route subsequently, produced evaporation fugitive pore formers. After thorough physico-chemical cell characterization, used for pre-clinical study. Soft hard tissue formation a rabbit femoral defect model after 2 4 months, assessed using different tools. Histological observations showed excellent osseous Sr...
Abstract To investigate the role of PTEN (phosphatase and tensin homolog) in mammalian target rapamycin complex 2 (mTORC2) signaling glioblastoma multiforme (GBM), we found higher activation mTORC2 mu cells, as evidenced by enhanced phosphorylation mTOR (Ser2481), AKT (Ser473) glycogen synthase kinase 3 beta (GSK3β) (Ser9) compared with wt cells. In addition, cells upon depletion showed activation. The reduced was related to Rictor at Thr1135 residue. Phosphorylation inhibited its...
Syntheses and crystal structures of four new hydrazone-based Cu(II) complexes, [{Cu(L1)(H2O)}2(μ-pyraz)](ClO4)2 (1), [{Cu(L1)(OClO3)}2(μ-4,4′-bipy)] (2), [{Cu(L2H)}(μ-pyraz){Cu(L2H)(OClO3)}].(ClO4) (3) [{Cu(L2)}2(μ-bpe)] (4) [L1H = condensation product benzhydrazide pyridine-2-carbaldehyde L2H2 benzoyl acetone benzhydrazide], bridged by various organic spacers [pyrazine (pyraz), 4,4′-bipyridine (4,4′-bipy) 1,2-di(4-pyridyl)ethane (bpe)] are reported in this paper. The single-crystal X-ray...
β-catenin plays a pivotal role in organogenesis and oncogenesis. Alterations expression are common pancreatic cancer, which is an extremely aggressive malignancy with notably poor prognosis. In this report, we analyzed the apoptotic activity of withanolide-D (witha-D), steroidal lactone that was purified from Indian medicinal plant, Withania somnifera, its underlying mechanism action. Witha-D induced apoptosis ductal adenocarcinoma cells by prompting cell-cycle arrest at G2/M phase. This...
The growth and survival of intracellular parasites depends on the availability extracellular nutrients. Deprivation nutrients viz glucose or amino acid alters redox balance in mammalian cells as well some lower organisms. To further understand relationship, mechanistic role L-arginine regulation mediated Leishmania donovani promastigotes was investigated. deprivation from culture medium found to inhibit cell growth, reduce proliferation increase uptake. Relative expression enzymes, involved...