A5086538185- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Healthcare and Venom Research
- Insect and Pesticide Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Yersinia bacterium, plague, ectoparasites research
- Immune Cell Function and Interaction
- Ion channel regulation and function
- Amphibian and Reptile Biology
- Immune Response and Inflammation
- Insect and Arachnid Ecology and Behavior
- Climate Change and Health Impacts
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Connexins and lens biology
- Traumatic Ocular and Foreign Body Injuries
- Bioactive Natural Diterpenoids Research
- Marine Toxins and Detection Methods
- Entomological Studies and Ecology
- Zoonotic diseases and public health
- Vector-borne infectious diseases
- Allergic Rhinitis and Sensitization
- Healthcare cost, quality, practices
The University of Melbourne
2015-2025
National Ageing Research Institute
2024
Walter and Eliza Hall Institute of Medical Research
1994-2007
The Royal Melbourne Hospital
1998-2007
Vestische Caritas-Kliniken
2007
Instituto Butantan
2004
Medical Center Hospital
2004
Virginia Commonwealth University
2004
Allegheny General Hospital
2004
Virginia Commonwealth University Medical Center
2004
Abstract Previous work indicated that a subclass of mouse spleen dendritic cells (DC), those bearing CD8alpha, expresses the Fas ligand and restricts peripheral CD4 T cell responses by initiating Fas-mediated apoptosis. To determine whether similar regulation applies to CD8 cells, they were purified from normal or TCR-transgenic mice, then cultured with splenic CD8+ DC CD8- presenting either alloantigens specific Ag for TCR transgene. In all systems studied, proliferative response was...
To assess the commitment of ten largest pharmaceutical companies operating in Australia to achieving net zero emissions by evaluating their accountability metrics, ambitions, and quantifiable actions taken. Cross-sectional study; analysis publicly available company reports published during 12 December 2015 - 31 2023. Ten Australia, defined total costs (to patients Pharmaceutical Benefits Scheme) for PBS-subsidised medications, as reported PBS expenditure prescriptions 2020-21 2022-23....
Abstract Tetanus toxoid‐specific T cell clones were isolated from a human donor. To determine the epitopes recognized by clones, 30 peptides representing amphipathic alpha helical regions of tetanus toxin screened for ability to induce proliferation clones. Two identified. These occurred within 12 and 21, had amino acid sequences NSVDDALINSTKIYSYFPSV PGINGKAIHLVNNESSE, respectively. An unusual feature was that both could be presented their respective antigen‐presenting cells many HLA...
The early thymus precursor population of adult mice has the capacity to generate T cells, B cells and dendritic (DC). These precursors were injected into irradiated recipients in order follow kinetics thymic DC development. resultant cohort T-lineage developing was accompanied by a parallel DC, present at 10(3)-fold lower frequency. intrathymic lifespan these as short that thymocytes. As matured, some markers characteristic original gradually declined (Ly-5, c-kit, Sca-2) whereas appeared...
The 19th century pathologist Rudolf Virchow was distinctive in his emphasis on multifocal and transdisciplinary thinking about the determinants of health disease. Most famously, he wrote a ground-breaking report for Prussian Government 1847–48 typhus outbreak region Upper Silesia, advocating free unlimited democracy as single most important principle addressing epidemic.1Taylor R Rieger A Medicine social science: epidemic Silesia.Int J Health Serv. 1985; 15: 547-559Crossref PubMed Scopus...
Patients with localized juvenile periodontitis (LJP) exhibit defective neutrophil functions to a variety of environmental and host stimuli. It is not clear, however, how many the measurable are whether individual patients single or multiple dysfunctions. The purpose this study was evaluate chemotaxis, phagocytosis, specific granule release Superoxide production in group 23 previously unreported LJP patients. Our results indicate that all these exhibited Chemotaxis depression...
The ubiquity of venom variation in snakes poses special problems for the manufacture antivenom and has undermined commercial attractiveness this class therapeutic agent. In particular, it been amply documented that both interspecific intraspecific composition can affect neutralisation capacity antivenoms. This may be exacerbated by selective use tests toxicity efficacy, such as lethal dose ED50, resulting inadequate time, rather than dose, dependent toxins, particularly enzymes involved...
Dangerous marine stingers (jellyfish) are an emotive issue in tropical Australia, where they widely regarded as the number one health threat. However, numerous severe and fatal stings have been reported throughout temperate seas of world, indicating that a global problem. Further, life-threatening jellyfish more frequently globally now compared to earlier decades, possibly result improved recognition reporting, or increased spatial and/or temporal distribution densities. As stinging...
Background Snake bite is a common medical emergency in Papua New Guinea (PNG). The taipan, Oxyuranus scutellatus, inflicts large number of bites that, the absence antivenom therapy, result high mortality. Parenteral administration antivenoms manufactured Australia current treatment choice for these envenomings. However, price products and has increased over last 25 years; consequently country can no longer afford all it needs. This situation prompted an international collaborative project...
Jellyfish are a common cause of injury throughout the world, with fatalities and severe systemic events not uncommon after tropical stings. The internet is recent innovation to gain information on real-time health issues travel destinations, including Southeast Asia.We applied model internet-based retrospective data aggregation, through Divers Alert Network Asia-Pacific (DAN AP), together more conventional methods literature media searches, document significance, clinical spectrum, box...
SUMMARY 1. We have investigated the cardiovascular pharmacology of crude venom extract (CVE) from potentially lethal, very small carybdeid jellyfish Carukia barnesi , in rat, guinea‐pig and human isolated tissues anaesthetized piglets. 2. In rat right atria, CVE (0.1–10 µg/mL) caused tachycardia presence atropine (1 µmol/L), a response almost completely abolished by pretreatment with tetrodotoxin (TTX; 0.1 µmol/L). paced left atria or (0.1–3 positive inotropic 3. mesenteric arteries, (0.1–30...