A5028188988- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Nitric Oxide and Endothelin Effects
- Peptidase Inhibition and Analysis
- Aortic aneurysm repair treatments
- Research on Leishmaniasis Studies
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Extracellular vesicles in disease
- Aortic Disease and Treatment Approaches
- Eicosanoids and Hypertension Pharmacology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Ubiquitin and proteasome pathways
Indian Institute of Technology Indore
2015-2024
The University of Texas Southwestern Medical Center
2023-2024
Southwestern Medical Center
2023
Government Medical College
2023
Japanese Red Cross Narita Hospital
2022
University of Tübingen
2022
Jamia Millia Islamia
2021
Lewisham and Greenwich NHS Trust
2020
Mayo Clinic in Arizona
2016
Albany Research Institute
2006-2015
Coronavirus disease (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the incessant spread of with substantial morbidity and mortality rates, there urgent demand for effective therapeutics vaccines control diminish this pandemic. A critical step in crosstalk between virus host cell binding SARS-CoV-2 spike protein angiotensin-converting enzyme (ACE2) receptor present on surface cells. Hence, inhibition interaction could be a...
Abstract The first steps of invasion and metastasis include the dissociation adherens junctions induction migratory phenotype, through a program that resembles epithelial-mesenchymal transition (EMT). L1 cell adhesion molecule, which is normally found primarily in brain, was recently shown to be expressed different types cancer have tumor-promoting activity. We now find mediates EMT-like events MCF7 breast carcinoma cells. predominantly expresses nonneuronal isoform L1, as do 16 17 other...
With the rapid growth of COVID-19 (coronavirus disease 2019) pandemic across globe, therapeutic attention must be directed to fight novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). However, developing new antiviral drugs and vaccines is time-consuming, so one best solutions tackle this virus at present repurpose ready-to-use drugs. This paper proposes repurposing Food Drug Administration (FDA)-approved, purchasable, naturally occurring for preventive use. We propose design...
The outbreak of the coronavirus disease 2019 caused by severe acute respiratory syndrome 2 triggered a global pandemic where control is needed through therapeutic and preventive interventions. This study aims to identify natural compounds that could affect fusion between viral membrane (receptor-binding domain spike protein) human cell receptor angiotensin-converting enzyme 2. Accordingly, we performed enzyme-linked immunosorbent assay-based screening 10 phytochemicals already showed...
To describe outcomes after elective and non-elective fenestrated-branched endovascular aortic repair (FB-EVAR) for thoracoabdominal aneurysms (TAAAs).
Nirmatrelvir is the main component of Paxlovid, an oral antiviral drug approved for treatment COVID-19 caused by SARS-COV-2 infection. targets protease (Mpro), which substantially conserved among different coronaviruses. Here, our molecular docking analysis indicates comparable affinity nirmatrelvir binding to Mpro enzymes SARS-CoV-2 and three seasonal coronaviruses (OC43, 229E NL63). However, in cell culture models, we found that potently inhibited SARS-CoV-2, OC43 229E, but not NL63. The...
Endemic seasonal coronaviruses cause morbidity and mortality in a subset of patients, but no specific treatment is available. Molnupiravir promising pipeline antiviral drug for treating SARS-CoV-2 infection potentially by targeting RNA-dependent RNA polymerase (RdRp). This study aims to evaluate the potential repurposing molnupiravir human coronavirus (HCoV) infections. Molecular docking revealed that active form molnupiravir, β-D-N4-hydroxycytidine (NHC), has similar binding affinity RdRp...
Background: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are prevalent chronic conditions that significantly affect elderly health, especially in India, where the dual occurrence of these diseases exacerbates cardiovascular risks. This study examines prescription patterns antihypertensive medications geriatric patients with both at a tertiary care center Maharashtra, India. Methods: A prospective, cross-sectional was conducted government medical college, Aurangabad, from March 2023...
Background: In India, the elderly population is particularly affected with diabetes and hypertension which prevalent in this population, leading to complex health challenges, necessitating effective treatment strategies. This study aimed analyze prescription patterns of antidiabetic drugs geriatric patients type 2 (T2DM) at a tertiary care center. Methods: A retrospective, cross-sectional was conducted government medical college, Chhatrapati Sambhaji Nagar, from March 2023 2024....
Background: The prescription patterns of antibiotics and analgesics in postoperative care are critical for optimal recovery. This study aims to analyse the utilization these medications cancer patients at a government hospital. Methods: A prospective, cross-sectional observational was conducted hospital, Aurangabad, from March 2023 August 2024. Prescription data were collected 321 patients, focusing on demographic details, drug classes, monotherapy versus combination therapy, adherence WHO...
Anticancer drugs are effective against tumors that depend on the molecular target of drug. Known targets cytotoxic anticancer involved in cell proliferation; acting such ineffective nonproliferating tumor cells, survival which leads to eventual therapy failure. Function-based genomic screening identified coatomer protein complex ζ1 ( COPZ1 ) gene as essential for different types but not normal cells. encodes a subunit 1 (COPI) intracellular traffic and autophagy. The knockdown COPZ1, COPZ2...
Genetic susceptibility to multiple sclerosis (MS) has been linked the HLA-DR15 haplotype consisting of DRB1*15:01(DR2b) and DRB5*01:01(DR2a) alleles. Given almost complete linkage disequilibrium two alleles, recent studies suggested differential roles in (DR2b) or protection from MS (DR2a). Our objective was assess potential contribution DR2a disease etiology using a humanized model autoimmunity. To etiology, we created transgenic (Tg) mice subsequently crossed them Tg expressing TL3A6, an...
Abstract Background COVID‐19 is caused by the coronavirus SARS‐CoV‐2, which uses angiotensin‐converting enzyme 2 (ACE‐2) as a receptor for cellular entry. It theorized that ACE inhibitors (ACE‐Is) or angiotensin blockers (ARBs) may increase vulnerability to SARS‐CoV‐2 upregulating ACE‐2 expression, but ACE‐I/ARB discontinuation associated with clinical deterioration. Objective To determine whether ACE‐I and ARB use acute kidney injury (AKI), macrovascular thrombosis in‐hospital mortality....