A5090887074- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cardiovascular Issues in Pregnancy
- Stress Responses and Cortisol
- Cardiovascular Function and Risk Factors
- Erythropoietin and Anemia Treatment
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Tattoo and Body Piercing Complications
- Neuroendocrine regulation and behavior
- Ovarian function and disorders
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infection Control in Healthcare
- Birth, Development, and Health
Institute of Cardiology
2020-2024
Corona (Poland)
2020-2024
Medical University of Warsaw
2015-2022
Cardinal Stefan Wyszyński University in Warsaw
2020
Central Clinical Hospital
2016-2019
Hospital of Prato
2019
Mossakowski Medical Research Institute, Polish Academy of Sciences
2016
University of Warsaw
2015
Left ventricular (LV) dysfunction after acute myocardial infarction (AMI) is associated with an increased risk of heart failure (HF) development. Diverse microRNAs (miRNAs) have been shown to appear in the bloodstream following various cardiovascular events. The aim this study was identify prognostic miRNAs LV AMI. Patients were divided into subgroups comprising patients who developed or not within six months infarction. miRNA profiles determined plasma and serum samples on first day Levels...
Abstract Aim To assess the safety, tolerability and pharmacokinetic (PK) profile of single multiple doses CPL207280, a new G‐protein‐coupled receptor 40 agonist developed to treat type 2 diabetes (T2D). Methods The phase 1 study in healthy volunteers (White, age 18–55 years, body mass index 18.5–29.9 kg/m ) was performed after (24 subjects, 5–480 mg) (32 60–480 once‐daily administration CPL207280. effect food intake interaction with metformin were evaluated additional cohort (12 120 mg)....
Background CPL’116 is a novel Janus kinase (JAK) and Rho-associated coiled-coil containing protein (ROCK) dual inhibitor promising drug candidate for the treatment of inflammatory fibrotic diseases. We conducted this first-in-human, Phase I clinical trial to evaluate safety, pharmacokinetics (PK), exploratory pharmacodynamics (PD) in healthy subjects. Methods White volunteers was after single (n = 21, 10–300 mg) multiple 32, 30–240 mg or placebo, 14-day b.i.d.) administrations including food...
Abstract Background COVID‐19 is caused by the coronavirus SARS‐CoV‐2, which uses angiotensin‐converting enzyme 2 (ACE‐2) as a receptor for cellular entry. It theorized that ACE inhibitors (ACE‐Is) or angiotensin blockers (ARBs) may increase vulnerability to SARS‐CoV‐2 upregulating ACE‐2 expression, but ACE‐I/ARB discontinuation associated with clinical deterioration. Objective To determine whether ACE‐I and ARB use acute kidney injury (AKI), macrovascular thrombosis in‐hospital mortality....
Acute myocardial infarction (AMI) is a life-threatening episode of coronary artery disease. Recently, circulating myocardial-derived microRNAs (miRNAs) have been reported as potential biomarkers infarction. The present study aimed to identify differentially expressed miRNAs in patients with ST-segment elevation that could be potentially dysregulated response early damage. miRNA expression profile analysis was performed using the Serum/Plasma Focus Polymerase Chain Reaction (PCR) panel Exiqon...
COVID-19, a disease caused by infection with the SARS-CoV-2 virus, is asymptomatic or mildly symptomatic in most cases. Some patients, usually burdened risk factors develop acute respiratory failure and other organ dysfunction. In such cases, mortality rate very high despite use of intensive therapy. Amantadine has complex activity including antiviral, antiinflammatory dopaminergic effects. This clinical trial will assess efficacy safety amantadine prevention COVID-19 progression toward...
Our study aimed to investigate the relationship between polymorphisms (Apa1, Bsm1, Fok1, and Cdx2) in VDR gene as well AMH AMHR2 genes their influence on 25(OH)D levels PCOS women. Seventy-five patients with 23 control women were included. Serum controls measured by enzyme-linked immunosorbent assay (ELISA). Polymorphisms Fok1 C/T (rs2228587), Bsm1 A/G (rs1544410), Apa1 A/C (rs7975232), Cdx2 (rs11568820) G/T (rs10407022) (rs2002555) analyzed using real-time PCR. Analysis of polymorphism...
Abstract MicroRNAs mediate posttranscriptional gene regulation. The aim of the study was to find a microRNA predictor successful atrial fibrillation (AF) ablation. A total 109 patients undergoing first-time AF ablation were included. Nineteen selected undergo serum sequencing (study group). data used select several microRNAs that correlated with 12-month recurrences after Those validated by digital droplet PCR in samples from remaining 90 patients. All underwent pulmonary vein isolation (RF...
Due to an increasing number of cesarean section deliveries, the common consequences that surgery are observed more often in population. One them is uterine scar defect known as niche or isthmocele. Most patients with aliment asymptomatic, but some can report abnormal bleeding, pelvic pain, subfertility which be reason for reduced quality life (QoL) patients. In our study, we analyzed subjective feelings changes severity symptoms and women after diagnostic operative hysteroscopy. The n = 85...
The present study focuses on the antibacterial activity of selected plant extracts against Paenibacillus larvae, causal agent American foulbrood disease honey bees. A gas chromatography-mass spectrometry method was used to analyze six diethyl ether two white birch species, black poplar and common aspen buds, as well n-hexane, ether, methanol young twigs from downy silver birches. Among identified extract constituents were flavonoids, phenylpropenoids, triterpenoids, glucosides. In spite...
Coronary bifurcation treatment poses a therapeutic challenge. The aim of this study was to analyze pooled data two randomized clinical trials, POLBOS I and II, compare 1-year follow-up results identify possible prognostic factors.In trials dedicated BiOSS® stents were compared with regular drug eluting (rDES) in patients stable coronary artery disease or non ST-segment elevation acute syndrome (POLBOS I: paclitaxel Expert vs. rDES; II: sirolimus LIM rDES). Provisional T-stenting the default...
Targeted therapy of non‑small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated improved prognosis. However, there is a shortage on data from real‑world clinical practice management EGFR‑positive NSCLC Poland. The present study retrospectively analyzed INSIGHT to evaluate incidence and authors additionally aimed identify predictors EGFR mutation factors stage tumor at diagnosis. Incidence was 11.8% most common were...
Introduction The wide variation in bifurcation anatomy has generated ongoing research for stents designed specifically coronary bifurcations; results to date have been unsatisfactory1,2. Earlier, we presented 12 months of pooled data from the POLBOS I and II trials (ClinicalTrials.gov Identifiers: NCT02192840, NCT02198300)3; present study extends follow-up four years. Methods OUTCOME MEASURES primary endpoint was cumulative rate major adverse cardiovascular events (MACE) consisting cardiac...
Maternal depression during pregnancy affects 18–20% of women and is often associated with comorbidities adverse health outcomes for the offspring. We have previously reported on neurodevelopmental delays in a rat model maternal pregnancy; current report presents echocardiographic (ECHO) data derived from same experiment focuses cardiovascular response offspring to perinatal depression. Rat dams were exposed chronic mild stress (CMS) repeated restraint before pregnancy. Cardiac functions...
Across cultures and generations, people have tattooed their bodies. Although blood-borne infections from tattooing been reduced, certain service aspects remain improperly managed. We assessed the infection risks associated with by conducting a cross-sectional study (2013-2014) in Poland using an anonymous questionnaire survey. Scoring procedures for tattooists clients were used. Overall, 255 interviewed. A quasi-random selection of tattoo parlors was based on register. Knowledge, attitudes,...
Abstract Introduction Among patients undergoing coronary artery bypass grafting (CABG), in a significant group chronic anticoagulant treatment is indicated. Current recommendations from scientific societies do not clearly indicate the optimal antithrombotic strategy this of patients. Addition antiplatelet therapy recommended after CABG to increases risk bleeding complications, however, efficacy strategies has been compared large prospective studies. Purpose The aim study was compare and...