A5000051541- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Retinoids in leukemia and cellular processes
- Digital Media Forensic Detection
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Generative Adversarial Networks and Image Synthesis
- Complement system in diseases
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Anomaly Detection Techniques and Applications
- Protein Degradation and Inhibitors
- Hemoglobinopathies and Related Disorders
- Handwritten Text Recognition Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Otitis Media and Relapsing Polychondritis
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- RNA modifications and cancer
- Blood groups and transfusion
- Digital and Cyber Forensics
- Erythrocyte Function and Pathophysiology
Cleveland Clinic
2023-2025
University of Rome Tor Vergata
2020-2024
University of Catania
2018-2024
Policlinico Tor Vergata
2021-2022
Sapienza University of Rome
2019
CBL proteins are a family of RING finger E3 ubiquitin ligases that regulate proliferative signals via ubiquitination and degradation tyrosine-phosphorylated signaling proteins, such as KIT, CSF-1, FLT3 PDGF [1].We previously described c-CBL mutations in myeloid neoplasia (MN), chiefly myelodysplastic/ myeloproliferative (MDS/MPN) syndromes chronic myelomonocytic leukemia [2, 3] juvenile [4].c-CBL mainly heterozygous, but some instances homozygous configuration can be found due to somatic...
Summary All‐ trans ‐retinoic acid (ATRA) and arsenic trioxide (ATO) represent the standard of care for low‐intermediate risk acute promyelocytic leukaemia (APL). Leucocytosis during induction with ATRA‐ATO represents a common complication an incidence up to 60%. To identify predictive factors this complication, we studied cohort 65 APL patients treated in three highly specialized Italian centres. Overall, 39/65 (60%) developed leucocytosis, peak leucocyte count being most frequent second...
Handwritten document analysis is an area of forensic science, with the goal establishing authorship documents through examination inherent characteristics. Law enforcement agencies use standard protocols based on manual processing handwritten documents. This method time-consuming, often subjective in its evaluation, and not replicable. To overcome these limitations, this paper we present a framework capable extracting analyzing intrinsic measures manuscript related to text line heights,...
Information regarding the incidence and prognostic impact of thrombotic events (TE) in non-promyelocytic acute myeloid leukemia (AML) is sparse. Although several risk factors associated with an increased TE development have been recognized, we still lack universally approved guidelines for identification management these complications. We retrospectively analyzed 300 consecutive patients newly diagnosed AML. Reporting venous (VTE) arterial (ATE) was primary endpoint. Secondarily, evaluated...
Hairy cell leukemia (HCL) is a rare lymphoproliferative disease with an excellent prognosis after treatment cladribine (2CDA), although relapse may occur during follow-up. The aim of the study to review efficacy, safety, long-term remission rate, and overall survival (OS) in those patients who received 2CDA as first-line treatment. We retrospectively reviewed data HCL treated between March 1991 May 2019 at 18 Italian Hematological centers: 513 were evaluable for purpose. median age was 54...
Background: The introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has radically improved the prognosis acute promyelocytic leukemia (APL), with cure rates above 80%. While relapse occurs in less than 20% cases, addressing this issue remains challenging. Identifying effective salvage therapies for relapsed APL is crucial to improve patient outcomes. Methods: A retrospective analysis was performed on a multicentric cohort 67 patients first relapse, treated three Italian...
Colonization by multidrug-resistant organisms (MDRO) is a frequent complication in hematologic departments, which puts patients at risk of life-threatening bacterial sepsis. Fever unknown origin (FUO) condition related to the delivery chemotherapy malignancies, use antibiotics debated. The incidence, factors, and influence on outcome these conditions with acute myeloid leukemia (AML) are not clearly defined.We retrospectively analyzed 132 consecutive admissions non-promyelocytic AML...
Therapy-related myeloid neoplasms (t-MN) arise after a documented history of chemo/radiotherapy as treatment for an unrelated condition and account 10–20% myelodysplastic syndromes acute leukemia. T-MN are characterized by specific genetic signature, aggressive features dismal prognosis. The nomenclature the subsets these conditions have changed frequently over time, despite fact that, in last classification, they lost their autonomous entity status became disease qualifiers, recognition...
Background and objectives Identification of latent tuberculosis infection (LTBI) is a critical step surveillance, especially in low incidence countries, limited to situations with higher probability developing active disease, e.g., patients hematological malignancies. According guidelines, TB non-endemic countries no clear screening program established at diagnosis for acute leukemia (AL). The primary endpoint this study was establish the LTBI AL using QuantiFERON (QFT)-TB. Secondarily,...
A new algorithm for the detection of deepfakes in digital videos is presented. The I-frames were extracted order to provide faster computation and analysis than approaches described literature. To identify discriminating regions within individual video frames, entire frame, background, face, eyes, nose, mouth, face frame analyzed separately. From Discrete Cosine Transform (DCT), β components from AC coefficients used as input standard classifiers. Experimental results show that eye mouth are...
Forensic handwriting examination is a branch of Science that aims to examine handwritten documents in order properly define or hypothesize the manuscript's author. These analysis involves comparing two more (digitized) through comprehensive comparison intrinsic local and global features. If correlation exists specific best practices are satisfied, then it will be possible affirm under were written by same individual. The need create sophisticated tools capable extracting significant features...
Several studies in immunocompromised patients, such as those with HIV infection, undergoing cancer chemotherapy or organ transplant, have led to the development of guidelines on use prophylaxis prevent Pneumocystis jirovecii pneumonia (PJP), these specific conditions. Instead, since association between PJP and acute myeloid leukaemia (AML) is not clearly defined, role patients AML yet established.We retrospectively analysed 251 consecutive newly diagnosed non-M3-AML, admitted at Hematology...