Subclinical hypothyroidism is a prevalent endocrine disorder, often associated with polycystic ovarian disease both of which share complex interplay hormonal imbalances, contributing to significant metabolic and reproductive disturbances. Objectives: To determine the frequency subclinical among patients presenting in an outpatient setting. Methods: This descriptive cross-sectional study was conducted at Obstetrics Gynaecology Department Fatima Memorial Hospital, Lahore, from December 2022...

Severe pulmonary embolism (PE) has a high mortality rate, which can be lowered by thrombolytic therapy (TT). However, full-dose TT is associated with major complications, including life-threatening bleeding. The aim of this study was to explore the efficacy and safety extended, low-dose administration tissue plasminogen activator (tPA) on in-hospital outcomes in massive PE.This single-center, prospective cohort trial at tertiary university hospital. A total 37 consecutive patients PE were...

<b><i>Objectives:</i></b> Arterial stiffness and epicardial fat thickness (EFT) are associated with coronary artery disease (CAD). The cardio-ankle vascular index (CAVI) is a novel marker of arterial stiffness. SYNTAX score (SS) reflects the complexity CAD. We aimed to evaluate relation EFT CAVI CAD in nondiabetic patients. <b><i>Method:</i></b> enrolled 121 patients undergoing angiography. In all patients, were determined. SS calculated....

Atrial fibrillation (AF) is the most common arrhythmia with an incidence of 25-40%, after coronary artery bypass grafting (CABG). Resistin a newly identified adipocyte-secreted hormone belonging to cysteine-rich protein family. This study examined relation preoperative and postoperative early serum resistin level, which can play important role as inflammatory marker predict AF CABG.We prospectively analyzed 40 consecutive patients (mean age, 59.2+10.3 years; 31 men nine women) who were...

In the present study, we aimed to evaluate temporal changes in heart-type fatty acid-binding protein (h-FABP) and myocardial performance index (Tei index) following administration of 5-fluorouracil (5-FU), a chemotherapeutic agent associated with ischemia induced by coronary vasospasm. Thirty-two patients cancer receiving their first 5-FU-based chemotherapy were included study. Prior 24 hours after initiation chemotherapy, all underwent comprehensive echocardiographic examination. Blood...

We investigated the relationship between peripheral artery disease complexity and coronary in patients with disease. A total of 449 were enrolled. SYNTAX score, a marker complexity, was assessed by dedicated computer software determined Trans Atlantic Inter-Society Consensus II classification. The score minimal disease, A, B, C D 5 (11), 12.5 (13.25), 20 (14), 20.5 (19) 27.5 (19), respectively (values brackets represent interquartile range). class moderately correlated (r = 0.495, p <...

Previous studies have demonstrated that inflammation, neurohormonal process and cardiovascular risk factors are associated with the development of coronary artery ectasia (CAE). However, underlying mechanisms responsible for formation not fully understood. The neutrophil to lymphocyte (N/L) ratio has recently emerged as a new inflammation marker disease.In this study, we hypothesised CAE could be more severe compared obstructive disease (O-CAD) regard N/L values.A total 405 patients isolated...

Endocan is a soluble proteoglycan, secreted by human vascular endothelial cells. marker for pathologies and an important mediator of angiogenesis, strongly associated with inflammation, dysfunction, atherosclerosis. The relationship between coronary artery ectasia (CAE) endocan has not been evaluated. We aimed to investigate this association. Fifty-four patients isolated CAE without stenosis 30 controls normal angiogram were included in study. plasma concentrations measured using...

<b><i>Background/Aims:</i></b> The Mehran risk score (MS) was adopted to predict the development of contrast-induced nephropathy (CIN) and includes clinical procedural variables. In this study, we aimed evaluate value MS in prediction CIN after transcatheter aortic valve implantation (TAVI). <b><i>Methods:</i></b> Ninety-three patients (47 females; mean age, 77.2 ± 7.6 years) who underwent replacement with TAVI for severe stenosis our center...

Prediction of severity or complexity coronary artery disease (CAD) is valuable owing to increased risk for cardiovascular events. Although the association between total calcium (CAC) score and CAD, Gensini was not used, it has been previously demonstrated. There no information about CAC CAD.To investigate assessed by SYNTAX (SS), respectively, score, which a noninvasive method CAD evaluation in symptomatic patients with accompanying significant CAD.Two-hundred-fourteen were enrolled. Total...

This study was designed to investigate the effects of dipper and nondipper patterns on global longitudinal systolic functions left ventricle (LV) by means two-dimensional speckle tracking echocardiography in treated hypertensive diabetic patients with preserved ventricular ejection fraction.We enrolled 86 patients. Twenty-four hour ambulatory blood pressure monitoring were performed each patient. The relationship between dipper/nondipper strain (GLS) analyzed.Fifty-one (59.3%) had a pattern....

Background Right ventricular ( RV ) function is known to be impaired in the presence of metabolic syndrome (MetS). Epicardial adipose tissue a metabolically active organ that generates various bioactive molecules, which might affect cardiac and morphology. Thus, we hypothesized dysfunction patients with MetS may related increased epicardial fat thickness EFT these patients. In MetS, aimed assess relation using two‐dimensional speckle tracking echocardiography (2D STE )‐derived strain rate...

Background: The aim of the present study was to assess relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by Syntax score (SS), severity in non-diabetic patients with stable CAD who underwent angiography, evaluate whether MS defined different definitions, including International Diabetes Federation (IDF) American Heart Association/National Lung Blood Institute (AHA/NHLBI) guidelines, similarly correlated SS. Methods: is cross sectional...

Transcatheter aortic valve implantation (TAVI) is a method which increasingly applied in severe stenosis treatment. The development of contrast-induced nephropathy (CIN) after TAVI increases morbidity and mortality rates. Within the scope this study, importance contrast medium volume to glomerular filtration rate (CV/GFR) ratio determining CIN amount CV that could be was evaluated.Seventy-two patients (aged 78.6 ± 11.6 years; 38 females) who underwent replacement with between June 2013...

Objectives: The aim of this study is to investigate the relationship between left ventricular thrombus (LVT) developments and SYNTAX score (SS) in patients undergoing primary percutaneous coronary intervention (PPCI) for first anterior wall ST-segment elevation myocardial infarction (STEMI). Methods: We enrolled 160 patients. All participants were evaluated by serial transthoracic echocardiography. Baseline clinical, echocardiographic, procedural features PPCI analyzed find predictors LVT...

Background: GRACE risk score (GS) is a scoring system which has prognostic significance in patients with non-ST segment elevation myocardial infarction (non-STEMI).Objective: The present study aimed to determine whether end-systolic or end-diastolic epicardial fat thickness (EFT) more closely associated high-risk non-STEMI according the GS.Methods: We evaluated 207 who had beginning from October 2012 February 2013, and 162 of them were included (115 males, mean age: 66.6 ± 12.8...

24-h ambulatory blood pressure monitoring (24-h ABPM) is a better predictor of cardiovascular events (CVEs) than spot (BP) measurements in hypertensive diabetic patients. In this patient group, the underlying mechanism relationship between nondipper pattern determined with ABPM and increased incidence CVE unknown. Cardioankle vascular index (CAVI) new overall arterial stiffness from aorta to ankle. The objective present study was evaluate dipper/nondipper patients using CAVI method.We...

Objective: To evaluate the predictive value of mean perfusion pressure (mPP) in development acute kidney injury (AKIN) after transcatheter aortic valve implantation (TAVI).Methods: One hundred and forty seven consecutive patients with stenosis (AS) were evaluated for this study 133 them included.Mean arterial (mAP) central venous (CVP) used to calculate mPP before TAVI procedure (mPP = mAP-CVP).The occurrence AKIN was classification according Valve Academic Research Consortium-2...

The aim of this study is to evaluate the incidence and predictors silent neuronal injury (SNI) after coronary angiography (CAG) intervention by serial measurement serum neuron-specific enolase (NSE) in patients presented with acute syndrome (ACS). Ninety-eight consecutive ACS underwent CAG were included study. NSE levels significantly increased compared baseline (22.03 ± 27.70 10.08 3.15 consecutively). Left ventricular ejection fraction SNI+ group was lower than that SNI− (43.71% 12.51%,...

Sewing needles, albeit a rare case of penetrating cardiac injury, are potentially life-threatening. We report self-inflicted remnant intracardiac sewing needle which is diagnosed with nonspecific chest pain and successfully extracted 23 months after its insertion.