A5000506257- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Intestinal and Peritoneal Adhesions
- Bone health and treatments
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Cancer Risks and Factors
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Psoriasis: Treatment and Pathogenesis
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Ovarian cancer diagnosis and treatment
- Bone health and osteoporosis research
- IL-33, ST2, and ILC Pathways
Saarland University
2018-2025
Abstract Background Monitoring individual therapy responses of patients with cancer represents a major clinical challenge providing the basis to early identify metastases and relapse. We previously demonstrated that radio- or chemoradiotherapy affects systemic cellular milieu vulvar cervical creates post-therapeutic environments associated Circulating tumor cells (CTCs) in are related relapse; however, their quantitative phenotypic characteristics during still unknown. Methods In this...
Abstract Purpose To assess changes in the pelvic floor anatomy that cause disorders (PFDs) primigravidae during and after pregnancy to evaluate their impact on women’s quality of life (QoL). Methods POP-Q translabial ultrasound examination was performed third trimester 3 months delivery a cohort with singleton delivering tertiary center. Results were analyzed regarding mode other pre- peripartal factors. Two individualized detailed questionnaires distributed at 12 childbirth determinate QoL....
Cervical cancer therapy is still a major clinical challenge, as patients substantially differ in their response to standard treatments, including chemoradiotherapy (CRT). During cervical carcinogenesis, T‐helper (Th)‐17 cells accumulate the peripheral blood and tumor tissues of are associated with poor prognosis. In this prospective study, we find increased Th17 frequencies after post‐therapeutic ratio Th17/CD4 + T > 8% was early recurrence. Furthermore, promote resistance toward CRT,...
Cervical cancer stage‑dependent therapies include surgery, chemotherapy, radiotherapy and chemoradiotherapy. Concurrent cisplatin‑based chemoradiotherapy (CCRT) is the standard therapy for locally advanced cervical carcinoma (FIGO>IIB), however resistance in a subset of patients still major clinical challenge. The present study aimed to analyze impact Oncostatin M (OSM) stimulation on CCRT‑induced cell death. used cells derived from squamous carcinomas (SW756, 808, CaSki 879) adenocarcinoma...
For vulvar cancers, radiotherapy is targeting cancer cells, but also affects the host immune system. As this may affect treatment outcome, in prospective study, we characterized individual T cell milieu induced by surgery and adjuvant radio +/- chemotherapy (aRT) systemically blood of patients found increased frequencies Interleukin (IL)-17-producing CD4+ CD8+ cells after aRT while Th1 perforin-producing killer were strongly diminished. Phenotypic characterization revealed enhanced...
Abstract During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients. We previously demonstrated that Th17 are associated with therapy resistance as well metastases relapse, however, underlying Th17-driven mechanisms supporting progression not fully understood yet. In this study, we found promote migration invasion 2D cultures 3D spheroids. induced expression miR-142-5p their invasiveness. As responsible mechanism, identified...
During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients. We previously demonstrated that Th17 are associated with therapy resistance as well metastases relapse; however, underlying Th17-driven mechanisms not fully understood. Here, using microarrays, we found induced an epithelial-to-mesenchymal transition (EMT) phenotype promoted migration invasion 2D cultures 3D spheroids via induction microRNA miR-142-5p. As...
Transiente Osteoporose ist eine schmerzhafte zeitlich begrenzte Erkrankung, deren Ursache bislang nicht geklärt wurde. Oftmals tritt sie im Bereich der Hüfte auf, selten sind auch andere knöcherne Bereiche wie die LWS betroffen. Betroffen unter anderem Frauen in Schwangerschaft, diese besonders 3. Trimenon und während Stillzeit.