A5044254353- CRISPR and Genetic Engineering
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- interferon and immune responses
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
University of Groningen
2016-2021
University Medical Center Groningen
2016-2021
Abstract Histone modifications reflect gene activity, but the relationship between cause and consequence of transcriptional control is heavily debated. Recent developments in rewriting local histone codes endogenous genes elucidated instructiveness certain marks regulating expression. Maintenance such repressive epigenome editing controversial, while stable reactivation still largely unexplored. Here we demonstrate sustained re-expression using two types engineered DNA-binding domains fused...
Abstract Chromosomal instability is a hallmark of cancer, but also an instigator aneuploidy-induced stress, reducing cellular fitness. To better understand how cells with CIN adjust to aneuploidy and adopt malignant fate in vivo , we performed genome-wide mutagenesis screen mice. We find that specifically aneuploid tumors inactivate Stat1 signaling combination increased Myc activity. By contrast, loss p53 common, not enriched tumors. Validation another tissue type confirmed promotes immune...