A5000660647- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Nuts composition and effects
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Ion Channels and Receptors
- Sleep and related disorders
- Stress Responses and Cortisol
- Medicinal Plants and Neuroprotection
- Hepatitis C virus research
- Exercise and Physiological Responses
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
Rafsanjan University of Medical Sciences
2015-2024
Endocrinology Research Center
2015-2019
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2019
Iran National Science Foundation
2014-2016
University of Oxford
2016
University of Benin
2013
Kerman University of Medical Sciences
2008-2013
Oman Medical College
2013
Ferdowsi University of Mashhad
2009
Tarbiat Modares University
2007
TRPV1 receptors and cannabinoid system are considered as important modulators of basal ganglia functions, their pharmacologic manipulation represents a promising therapy to alleviate Parkinson-induced hypokinesia. Recent evidence suggests that the blockade might be beneficial motor deficits observed in Parkinson's disease. In present study, we have evaluated effects AMG9810 , selective antagonist receptors, on cognitive functions rat model disease generated by an intracerebroventricular...
Delayed treatment of stroke with recombinant tissue plasminogen activator (r-tPA) induces overexpression matrix metalloproteinase 9 (MMP-9) which leads to breakdown the blood–brain barrier (BBB) and causes more injuries brain parenchyma. In this study, effect ascorbic acid (AA), an antioxidant agent, on delayed administration r-tPA in a rat model permanent middle cerebral artery occlusion (MCAO) was investigated. Forty male rats were randomly divided into four groups: untreated control...
Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant anti-inflammatory properties. The present study investigated possible effect of on D-galactose (D-gal)-induced aging in mice.Met (1 10 mg/kg/p.o.), was administrated daily D-gal-received (500 mg/kg/p.o.) mice model for six weeks. Anxiety-like behavior, cognitive function, physical power were evaluated by...
Objective: The aim of this study was to evaluate the effect orexin-A (OX-A) and orexin-1 receptor antagonist SB-334867 (SB) on motor cognitive functions in a rat model Parkinson's disease. Methods: Parkinson induced by intracerebroventricular (i.c.v) injection 6- hydroxydopamine (6-OHDA) (200 μg/rat). 72 h later, treatment initiated i.c.v administration SB (30 nmol/rat) and/or OX-A (0.3 for 10 days. Motor were monitored using rotarod hanging tests. Cognitive function assessed passive...
Summary The impact of several environmental and genetic factors on diabetes its complications is well documented but there an urgent need to understand more about risk associated with this disease. present study was aimed at examining the two single nucleotide polymorphisms (SNP) in intron 8 exon 9 vitamin D receptor (VDR) gene nephropathic non‐nephropathic type‐2 diabetic patients. In clinical study, peripheral blood samples were obtained from 100 patients, patients healthy controls. DNA...
<b>Background/Aim:</b> Occult hepatitis B infection (OBI) is identified as a form of in which despite the absence detectable HBsAg, HBV-DNA observed peripheral blood patients. The main aim this study has been to investigate association between polymorphisms +874 IFN-γ and +1188 IL-12 with their serum level patients suffering from OBI. <b>Materials Methods:</b> In experimental study, plasma samples 3700 donors were tested for presence surface antigen (HBsAg) anti-HBc by ELISA. HBsAg...
Convulsive seizures are due to abnormal synchronous and repetitive neuronal discharges in the central nervous system (CNS). Finding new therapeutics overcome side effects of current drug therapies increase their effectiveness is ongoing. Orexin-A orexin-B brain neuropeptides originating from postero-lateral hypothalamic neurons. Studies show that orexins, through activation OX1 OX2 receptors, have excitatory CNS. Accordingly, this study was designed evaluate effect receptor antagonist...
Background and Aim Pre‐term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL 12 ( SDF ‐1) 10 IP ‐10) in cord blood term pre‐term delivered fetuses their corresponding mothers. Material Methods Cord peripheral samples were collected from 50 infants Serum measured by ELISA . Results The findings this study indicated that elevated mothers bearing infants, while was only increased infants. Conclusion results suggested...
Purpose: Pistacia vera is a plant of the family Anacardiaceae found in Central and West Asia. P. nut (Pistachio) possess multiple pharmacological effects such as antimicrobial, anti-hyperlipidemia, antioxidant anti-inflammatory. This study designed to evaluate protective effect hydroalcoholic extract pistachio on gentamicin-induced nephrotoxicity rats.Methods: Nephrotoxicity was induced rats by intraperitoneal injection gentamicin (100 mg/kg/day for 7 days). Hydroalcoholic (10, 50 100...
Cisplatin (Cis) is an anticancer compound, which used for the treatment of various cancers. Sumatriptan (Suma) a selective agonist 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, prescribed management migraine. It well-established that Suma has anti-inflammatory and antioxidant properties. We have explored protective effects in mitigation Cis-induced nephrotoxicity.The mice received single IP injection Cis (20 mg/kg) on first day experiment. (0.1 0.3 mg/kg/day, IP) was started 1 continued 3...