A5037263258- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Apelin-related biomedical research
- Renin-Angiotensin System Studies
- Bacteriophages and microbial interactions
- Traffic and Road Safety
- Drilling and Well Engineering
- Electrospun Nanofibers in Biomedical Applications
- Cannabis and Cannabinoid Research
- Eicosanoids and Hypertension Pharmacology
- Sleep and Wakefulness Research
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Neurological Disorders and Treatments
- Magnesium in Health and Disease
- Periodontal Regeneration and Treatments
- Rabies epidemiology and control
- Cancer, Stress, Anesthesia, and Immune Response
- Cholinesterase and Neurodegenerative Diseases
- Innovations in Concrete and Construction Materials
- Natural Products and Applications
Fasa University of Medical Sciences
2007-2024
Czech Academy of Sciences, Institute of Physiology
2005
Kerman University of Medical Sciences
2002
Shell (Japan)
1992-1993
Abstract Biodegradable microparticles are useful vehicles for the controlled release of bioactive molecules in drug delivery, tissue engineering and biopharmaceutical applications. We developed dexamethasone (Dex) encapsulation into tyramine-substituted hyaluronic acid (Dex-HA-Tyr Mp) mediated by horseradish peroxidase (HRP) crosslinking using a microfluidic device infollowing crosslinked gelatin (Gela) with proanthocyanidin (PA) as semi-confined bed hydrogel repair sciatic injury. It was...
Abstract Background This study aimed to evaluate the protective effects of alamandine, a new member angiotensin family, against doxorubicin (DOX)-induced nephrotoxicity in rats. Methods Rats were intraperitoneally injected with DOX (3.750 mg/kg/week) reach total cumulative dose 15 mg/kg by day 35. Alamandine (50 µg/kg/day) was administered rats via mini-osmotic pumps for 42 days. At end experiment, placed metabolic cages 24 h so that their water intake and urine output could be measured....
Background and Objectives: Pseudomonas aeruginosa (P. aeruginosa) Klebsiella pneumoniae (K. pneumoniae) are the two leading bacterial strains involved in wound infections. These bacteria have developed broad resistance to antibi- otics, which has complicated their eradication. Additionally, formation of a polymicrobial infection poses additional problems. Among alternative or complementary options, bacteriophages, viruses that parasitize hosts, been promising. Materials Methods: In this...
The aim of this present study is to investigate the prevalence alcohol and substance abuse (ASA) its relationship with other risky driving behaviors among motorcycle drivers.This a cross sectional which performed at Shiraz city Iran. Data from drivers were collected using standard questionnaire in eight major streets different times day. data includes consumption substances two hours before some during driving.A total 414 mean ± SD age (27.0 9.3) years participated study. Alcohol or...
Doxorubicin (DOX) is an anthracycline antibiotic. Despite its unwanted side effects, it has been successfully used in tumor therapy. Given that oxidative stress and inflammatory factors are essential to cardiotoxicity caused by DOX, we assumed alamandine, which enhances endogenous antioxidants anti-inflammatory may prevent DOX-induced cardiotoxicity. Rats received DOX (3.75 mg/kg) i.p on days 14, 21, 28, 35 (total cumulative dose = 15 alamandine (50 μg/kg/day) via mini-osmotic pumps for 42...
1 Recent studies have suggested that the basolateral nucleus of amygdala (BLA) participates in processing pain information, especially noxious somatic information. Cannabinoid receptors or CB1 mRNA are expressed more BLA than other nuclei amygdala. Thus, aim present study was to examine whether may be involved modulating acute and/or tonic nociceptive processing. 2 Adult rats were exposed intra-BLA microinjection cannabinoid receptor agonist...
Alamandine is a newly discovered component of the renin-angiotensin system, which regulates blood pressure. In this study, effect alamandine on cardiovascular parameters in two-kidney, one clip (2K1C) hypertensive rats and normotensive rats, possible roles angiotensin II type 1 receptor (AT1R) PD123319-sensitive receptors mediating was investigated.Methods Results:The were monitored for 10 min before infusion drugs or saline, 30 afterward. 2K1C caused brief increases mean arterial pressure...
Crash helmet plays an important role in protecting the deriver's head during crashes and reduces rate of severe injuries fatalities. Although it has been proved that wearing crash can save life by around 42%; previous studies showed not acceptable Iran. Due to huge number motorcyclists on roads Iran, use is area research. The aim this study was assess factors could possibly relate or affect motorcyclists.This observational 414 Shiraz, Southern All participants completed a questioner...
1. Supraspinal opioid antinociception is mediated, in part, by connections between the periaqueductal grey (PAG) and rostral ventromedial medulla (RVM). Morphine from PAG decreased serotonin, N-methyl-d-aspartate (NMDA) receptor antagonists administered into RVM. Because brain isoform of nitric oxide synthase (NOS) also prominent RVM, present study was designed to evaluate effects microinjection non-selective NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) non-competitive NMDA...
Pulmonary arterial hypertension (PAH) is a severe and often fatal disease that associated with oxidative stress inflammation. Alamandine, component of the renin-angiotensin system, known for its antioxidative, anti-inflammatory, antifibrotic effects, has been investigated in this study to determine if it protective effects against PAH induced by monocrotaline (MCT) these are stress, inflammatory factors, inducible nitric oxide synthase (iNOS).
Alamandine is a new member of the angiotensin family. Here, we studied mRNA and protein expression cardiac angiotensin-converting enzyme 2 (ACE2) in chronic phase rat model 2-kidney, 1-clip hypertension (2K1C), effects 2-week alamandine infusion on blood pressure, indices, ACE2 hearts. The rats were subjected to sham-operation or placement plexiglass clips around left renal artery. Alamandine, at dose 600 µg/kg/d, was administered for weeks via an osmotic mini-pump. At 18 weeks, after...
Abstract Cholestasis is associated with changes including analgesia. The endocannabinoid system can reduce pain sensitivity. Considering the interaction between endogenous opioid and systems in nociception processing, we studied effect of UCM707 as a potent selective inhibitor uptake on modulation model elevated tone, cholestasis. was induced male Sprague–Dawley rats by ligation main bile duct using two ligatures transecting at midpoint them. Seven days later, tail‐flick latencies were...
A meta-analysis of randomized controlled trials investigating tirofiban combined with conventional drugs by intracoronary administration for no-reflow prevention
Abstract Background: The objective of this study was to evaluate the protective effects alamandine, a new member angiotensin family, against doxorubicin (DOX)-induced nephrotoxicity in rats. Methods: Rats, intraperitoneally injected with DOX (3.750 mg/kg/week) reach total cumulative dose 15 mg/kg on day 35. Alamandine (50µg/kg/day) administered rats via mini-osmotic pumps for 42 days. At end experiment, were placed metabolic cages 24 h measurement water intake and urine output. After...
Abstract The design, synthesis and biological evaluation of some aryloxy propanol amino acid derivatives have been described. Synthetic pathways is consisted the reaction phenol with epichlorohydrin and/or epibromohydrin produced various O‐phenol ether adducts. In continue, adducts generated new class β‐blocking agents. products were evaluated for their cardiovascular property. 2‐kidney‐1‐clip method was used to induce renovascular hypertension in rats. New analogues propranolol order find...