Liver is considered a target organ affected by lead toxicity. Oxidative stress among the mechanisms involved in liver damage. Here we investigated effects of natural alkaloid berberine on oxidative and hepatotoxicity induced rats.Animals received an aqueous solution acetate (500 mg Pb/l drinking water) and/or daily oral gavage (50 mg/kg) for 8 weeks. Rats were then weighed used biochemical, molecular, histological evaluations.Lead-induced stress, shown increasing lipid peroxidation along...

Cognitive impairment occurs in diabetes mellitus. Glabridin as a major active flavonoids Glycyrrhiza glabra (licorice) improves learning and memory mice. In the present study, we investigated effect of chronic treatment with glabridin (5, 25 50 mg/kg, p.o.) on cognitive function control streptozotocin (STZ)-induced diabetic rats.Animals were divided into untreated control, glabridin-treated mg/kg), treated mg/kg) groups. Treatments begun at onset hyperglycemia. Passive avoidance (PAL) was...

Abstract Cognitive impairment occurs in diabetes mellitus. Hypericum perforatum has been used folk medicine to improve mental performance. Here it is hypothesized that chronic treatment with an extract of (6, 12 and 25 mg/kg, p.o.) would have effects on passive avoidance learning (PAL) memory control streptozotocin‐induced diabetic rats. Treatments were begun at the onset hyperglycaemia. PAL was assessed 30 days later. A retention test done 24 h after training. At end, animals weighed blood...

Background:Cognitive impairment occurs in diabetes mellitus. Teucrium polium L. (Lamiaceae) has been used folk medicine to improve mental performance. Here we hypothesized that chronic treatment with an aqueous extract of (100, 200 and 400 mg/kg, p.o.) would have effect on passive avoidance learning (PAL) memory control streptozocin-induced diabetic rats.Material/Methods:Treatments were begun at the onset hyperglycemia, PAL was assessed 30 days later. A retention test performed 24 h (hours)...

Context: Drug-induced liver injury is a significant worldwide clinical problem. Rosmarinic acid (RA), natural phenol, has antioxidant effects.Objective: The effects of RA against acetaminophen (N-acetyl-p-amino-phenol (APAP))-induced oxidative damage and hepatotoxicity in rats were investigated.Materials methods: Male Wistar pretreated with (10, 50 100 mg/kg, i.g.) for one week. On day 7, received APAP (500 i.p.). Then aspartate aminotransferase (AST), alanine (ALT), albumin, total protein,...

Lead affects multiple organ systems including testis. We investigated the effects of ferulic acid (FA) on lead-induced oxidative stress and spermatogenesis suppression in rats. Animals received lead acetate (500 mg/L drinking water) and/or FA (50 mg/kg, i.g.) for eight weeks. increased testicular malondialdehyde (MDA) nitrite levels decreased glutathione (GSH) content catalase (CAT) activity. testis weight testosterone level. Sperm parameters group. ameliorated weight, serum as well sperm...

<b><i>Objective:</i></b> The efficacy of oral administration <i>Melissa officinalis</i> essential oil (MOEO) on hyperalgesia was investigated using the formalin test in streptozotocin (STZ)-induced diabetic rats. <b><i>Materials and Methods:</i></b> Animals were divided into control, MOEO-treated control (0.01, 0.02 0.04 mg/day), mg/day) groups. Nociceptive testing performed male adult Wistar rats 4 weeks after onset hyperglycemia....

Objectives: Cognitive impairment and hyperalgesia are among the common manifestations of diabetes. Hyperglycemia may contribute to their developments but exact pathophysiology underlying these complications is not fully understood. Flavonoids from plants original have beneficial effects on diabetes by improving glycemic control. Rutin (RUT) a bioflavonoid found in many foods with biological activities including neuroprotective antidiabetic effects. In this study, we hypothesized that...

Diabetic neuropathic (DN) pain is one of the diabetes complications. Rosmarinic acid (RA), a natural phenol antioxidant, shows some biological activities, including anti-inflammatory, analgesic, and anti-diabetic effects.We investigated efficacy RA administration (10 30 mg/kg) on streptozotocin (STZ)-induced neuropathy in rats.The animals received saline or mg/kg, p.o.; once daily) for 8 weeks. DN was evaluated by tail flick (TF) method, formalin test, tactile allodynia. At end, all rats...

The kidney is one of the main organs affected by nickel toxicity. We investigated protective effects carnosine on nickel-induced oxidative stress in rats. Animals received NiSO4 (20 mg·kg-1·day-1 intragastrically) and (or) (10 for 21 days then were evaluated biochemical, molecular, histopathological alterations. Nickel caused an increase renal levels malondialdehyde a decrease reduced glutathione, catalase, superoxide dismutase total antioxidant capacity. Carnosine prevented prooxidant...

Context Oxidative stress is a common mechanism of liver injury. Carnosine dipeptide having strong antioxidant effects. Objectives We investigated the effects carnosine on lead-induced hepatotoxicity and oxidative in rats. Materials methods Animals received an aqueous solution lead acetate (500 mg Pb/L drinking water) and/or daily oral gavage (10 mg/kg) for 8 weeks. Rats were then weighed used biochemical (commercial kits), molecular (standard chemical methods) histological (microscopic)...

Anxiety and stress are considered as universal psychiatric exhibitions of the present societies lifestyles. Several experiments have been conducted to examine natural anxiolytic agents find out an alternative synthetic drugs. The study investigated effects cinnamaldehyde (Cin) on mice behavior in elevated plus maze (EPM) open field (OF) tests. Sixty male Swiss mice, weighing 20–30 g, were divided into six groups including: acute + mazola oil; chronic Cin (20 mg/kg); Cin; non-stress groups....

Developing new therapeutic drugs to prevent ischemia/reperfusion (I/R)-induced renal injuries is highly pursued. Liposomal encapsulation of spironolactone (SP) as a mineralocorticoid antagonist increases dissolution rate, bioavailability and prevents the drug from degradation. In this context, work develops formulation oil-in-water type microemulsions enhance SP. The size SP-loaded microemulsion was about 6.0 nm by dynamic light scattering analysis. Briefly, we investigated effects...

1 Recent studies have suggested that the basolateral nucleus of amygdala (BLA) participates in processing pain information, especially noxious somatic information. Cannabinoid receptors or CB1 mRNA are expressed more BLA than other nuclei amygdala. Thus, aim present study was to examine whether may be involved modulating acute and/or tonic nociceptive processing. 2 Adult rats were exposed intra-BLA microinjection cannabinoid receptor agonist...

The effects of unilateral intra-ventral hippocampus injection URB597, a fatty acid amid hydrolase inhibitor, and AM251, selective CB(1) receptor antagonist, on anxiety-related behaviours using elevated plus-maze test anxiety were evaluated in the present study. Possible involvement GABAergic system those URB597 was also evaluated. Injection at doses 0.01, 0.1 1 microg/rat showed significant anxiogenic-like microg/rat. However, AM251 0.001, 0.01 did not produce any effect plus-maze....