Aleš Holobar

ORCID: 0000-0001-8338-5978
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Muscle activation and electromyography studies
  • Motor Control and Adaptation
  • Neurological disorders and treatments
  • Neuroscience and Neural Engineering
  • EEG and Brain-Computer Interfaces
  • Sports Performance and Training
  • Blind Source Separation Techniques
  • Parkinson's Disease Mechanisms and Treatments
  • Transcranial Magnetic Stimulation Studies
  • Genetic Neurodegenerative Diseases
  • Advanced Sensor and Energy Harvesting Materials
  • Children's Physical and Motor Development
  • Cerebral Palsy and Movement Disorders
  • Muscle metabolism and nutrition
  • Cardiovascular and exercise physiology
  • Spectroscopy and Chemometric Analyses
  • Balance, Gait, and Falls Prevention
  • Spinal Cord Injury Research
  • Botulinum Toxin and Related Neurological Disorders
  • Musculoskeletal pain and rehabilitation
  • Muscle Physiology and Disorders
  • Photoreceptor and optogenetics research
  • Speech and Audio Processing
  • Sports injuries and prevention
  • Glycogen Storage Diseases and Myoclonus

University of Maribor
2015-2024

Loughborough University
2022

Friedrich-Alexander-Universität Erlangen-Nürnberg
2022

Versus Arthritis
2022

Polytechnic University of Turin
2007-2010

The aim of the study was to investigate relation between linear transformations motor unit discharge rates and muscle force. Intramuscular (wire electrodes) high‐density surface EMG (13 × 5 electrode grid) were recorded from abductor digiti minimi eight healthy men during 60 s contractions at 5%, 7.5% 10% maximal Spike trains a total 222 units identified recordings with decomposition algorithms. Principal component analysis smoothed indicated that one (first common component, FCC) described...

10.1113/jphysiol.2009.178509 article EN The Journal of Physiology 2009-10-20

We propose and validate a method for accurately identifying the activity of populations motor neurons during contractions at maximal rate force development in humans. The behaviour neuron pool rapid voluntary humans is presented. show with this approach that recruitment speed unit discharge largely explains individual ability generating contractions. results also indicate synaptic inputs received by before generated dictate human potential to generate rapidly. This first characterization...

10.1113/jp277396 article EN The Journal of Physiology 2019-02-15

This study addresses online decomposition of high-density surface electromyograms (EMG) in real time. The proposed method is based on the previously published Convolution Kernel Compensation (CKC) technique and shares same paradigm, i.e., compensation motor unit action potentials direct identification (MU) discharges. In contrast to version CKC, which operates batch mode requires ~ 10 s EMG signal, real-time implementation begins with processing 3 signal initialization stage continues...

10.1109/tnsre.2013.2247631 article EN IEEE Transactions on Neural Systems and Rehabilitation Engineering 2013-03-06

Redundancy of the neuromuscular system theoretically allows for a redistribution neural drive across muscles (i.e., between-muscle compensation) during fatiguing contraction. Our results suggest that high level common input between (e.g., vastus lateralis and medialis) represents constraint making it less likely to redistribute these muscles. In this way, was only observed share little synaptic gastrocnemius medialis).

10.1152/jn.00453.2021 article EN Journal of Neurophysiology 2022-01-12

This paper presents the fully automatic identification of motor unit spike trains from high-density surface electromyograms (EMG) in pathological tremor. First, a mathematical derivation is provided to theoretically prove possibility decomposing noise-free EMG signals into with high correlation, which are typical tremor contractions. Further, proposed decomposition method tested on simulated different levels noise and experimental 14 tremor-affected patients. In case central frequency...

10.1088/1741-2560/9/5/056011 article EN Journal of Neural Engineering 2012-09-10

Recent advances in high-density surface electromyogram (EMG) decomposition have made it a feasible task to discriminate single motor unit activity from EMG interference patterns, thus providing noninvasive approach for examination of control properties. In the current study, we applied recording and techniques assess firing behavior alterations poststroke. Surface signals were collected using 64-channel 2-D electrode array paretic contralateral first dorsal interosseous (FDI) muscles nine...

10.1109/tbme.2014.2368514 article EN IEEE Transactions on Biomedical Engineering 2014-11-07

Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of motoneuron firing. As PICs highly sensitive to synaptic inhibition facilitated by serotonin noradrenaline, we hypothesised that both reciprocal (RI) induced antagonist nerve stimulation whole-body relaxation (WBR) would reduce in humans. To test this, estimated using the well-established paired motor unit (MU) technique. High-density surface electromyograms were recorded from gastrocnemius medialis...

10.1113/jp282765 article EN cc-by The Journal of Physiology 2022-04-18

Abstract Purpose The purpose of this study was to compare laterality in motor unit firing behavior between females and males. Methods Twenty-seven subjects (14 females) were recruited for study. participants performed ramp up hold isometric index finger abduction at 10, 30, 60% their maximum voluntary contraction (MVC). High-density surface electromyography (HD-sEMG) signals recorded the first dorsal interosseous (FDI) muscle decomposed into individual (MU) using a convolution blind source...

10.1007/s00421-024-05420-7 article EN cc-by European Journal of Applied Physiology 2024-02-16

Tremor in essential tremor (ET) is generated by pathological oscillations at 4–12 Hz, likely originating cerebello-thalamo-cortical pathways. However, the way which represented output of spinal cord circuitries largely unknown because difficulties identifying behavior individual motor units from tremulous muscles. By using novel methods for decomposition multichannel surface EMG, we provide a systematic analysis discharge properties nine ET patients, with concurrent recordings EEG activity....

10.1152/jn.00531.2014 article EN Journal of Neurophysiology 2014-10-02

The pathophysiology of essential tremor (ET), the most common movement disorder, is not fully understood. We investigated which factors determine variability in phase difference between neural drives to antagonist muscles, a long-standing observation yet unexplained. used computational model simulate effects different levels voluntary and tremulous synaptic input antagonistic motoneuron pools on tremor. compared these simulations data from 11 human ET patients. In both analyses, drive muscle...

10.1523/jneurosci.0106-15.2015 article EN Journal of Neuroscience 2015-06-10

The aim of this study was to assess the accuracy convolution kernel compensation (CKC) method in decomposing high-density surface EMG (HDsEMG) signals from pennate biceps femoris long-head muscle. Although CKC has already been thoroughly assessed parallel-fibered muscles, there are several factors that could hinder its performance muscles. Namely, HDsEMG and muscles differ considerably terms number detectable motor units (MUs) spatial distribution motor-unit action potentials (MUAPs). In...

10.1088/1741-2560/8/6/066002 article EN Journal of Neural Engineering 2011-10-01

We investigated the changes in muscle fiber conduction velocity, recruitment and derecruitment thresholds, discharge rate of low-threshold motor units during a series ramp contractions. The aim was to compare adjustments unit activity relative duration that each active task. Multichannel surface electromyographic (EMG) signals were recorded from abductor pollicis brevis eight healthy men 12-s contractions (n = 25) which force increased decreased linearly 0 10% maximum. maximal exhibited...

10.1152/jn.90968.2008 article EN Journal of Neurophysiology 2008-11-12

Introduction: We investigated the motor unit (MU) firing pattern in type 2 diabetes mellitus (T2DM) patients by means of multichannel surface electromyography (SEMG). Methods: Eight T2DM and 8 age-matched, healthy men performed a ramp-up contraction to 20% maximal voluntary (MVC). They also sustained at 10% MVC during isometric knee extension. Multichannel SEMG signals recorded from vastus lateralis muscle were decomposed with convolution kernel compensation technique extract individual MU...

10.1002/mus.23828 article EN Muscle & Nerve 2013-02-28

Although the cerebello-thalamo-cortical network has often been suggested to be of importance in pathogenesis essential tremor (ET), origins tremorgenic activity this disease are not fully understood. We used a combination cortical thickness imaging and neurophysiological studies analyze whether severity was associated with anatomical changes brain ET patients.Magnetic resonance (MRI) assessment were performed 13 nondemented patients. High field structural MRI images acquired 3T scanner...

10.1002/acn3.681 article EN cc-by-nc-nd Annals of Clinical and Translational Neurology 2018-11-08

We analysed the cramp threshold (i.e. minimum frequency of electrical stimulation capable inducing a cramp) and behaviour individual motor units during cramps electrically elicited in absence (intact condition) presence (blocked peripheral nerve block eight healthy subjects. The was significantly greater blocked than intact condition (18 ± 3 Hz vs. 13 Hz; P = 0.01). Cramp duration peak EMG amplitude (55.6 19.2 s 47.5 24.8 μV, respectively) were compared to (2.6 1.3 13.9 8.8 μV; < All...

10.1113/jphysiol.2011.212332 article EN The Journal of Physiology 2011-10-04
Coming Soon ...