A5101471103- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Surfactants and Colloidal Systems
- Cancer Genomics and Diagnostics
- Catalytic Cross-Coupling Reactions
- Chemical Reactions and Mechanisms
- Cyclopropane Reaction Mechanisms
- HER2/EGFR in Cancer Research
- Analytical Chemistry and Chromatography
- Molecular Biology Techniques and Applications
- NMR spectroscopy and applications
- Electrostatics and Colloid Interactions
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Lanthanide and Transition Metal Complexes
- Lipid Membrane Structure and Behavior
- Sulfur-Based Synthesis Techniques
- Gene expression and cancer classification
- Genomic variations and chromosomal abnormalities
- Organometallic Complex Synthesis and Catalysis
- Electron Spin Resonance Studies
- Cancer-related Molecular Pathways
Max-Planck-Institut für Kohlenforschung
2023-2025
RWTH Aachen University
2023-2025
Pusan National University
2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
Glostrup Hospital
2007-2012
Wissenschaftliches Institut der AOK
1987
University of Göttingen
1980-1982
Max Planck Institute for Biophysical Chemistry
1980
Thianthrenation is a useful strategy for the late-stage diversification of complex small molecules owing to positional selectivity and synthetic versatility thianthrenium salts as electrophilic linchpins. However, substrate-dependent identification suitable reaction conditions thianthrenation can be difficult. Reported functionalization vary significantly and, in some instances, lack robustness practicality. Herein, we report generalized approach preparation two manifolds practical, robust,...
Abstract Purpose: Amplified in breast cancer 1 (AIB1) is a member of the p160/steroid receptor coactivators family and involved estrogen-dependent gene transcription by reducing antagonistic activity tamoxifen-bound estrogen receptor-α (ER-α). The present study was carried out to test hypothesis that AIB1 protein expression and/or amplification mediates tamoxifen resistance cancer. Experimental Design: Immunohistochemistry using antibody fluorescence situ hybridization probes specific for...
Abstract By leveraging the fast oxidative addition of arylthianthrenium salts (aryl‐TT + ) to palladium(0), a regioselective diazoester installation has been developed. This approach enables introduction diazo moiety densely functionalized arenes at late stage. The installed group is amenable facile further derivatization.
Abstract By leveraging the fast oxidative addition of arylthianthrenium salts (aryl‐TT + ) to palladium(0), a regioselective diazoester installation has been developed. This approach enables introduction diazo moiety densely functionalized arenes at late stage. The installed group is amenable facile further derivatization.
Here, we show the conversion of unactivated alkenes into α-branched enones via regioselective chloroacylation with acyl chlorides. The method relies upon initial in situ generation chlorine radicals directly from chloride precursor under cooperative nickel/photoredox catalysis. Subsequent HCl elimination provides and α,β-unsaturated esters that are not accessible conventional acylation approaches provide other, linear constitutional isomer.
Pd-catalyzed alkenylations of metallocenes via C-H activation were developed using electronically tunable pyrazolonaphthyridine (PzNPy) ligands. Ferrocene was alkenylated the most electron-deficient ligand in series, whereas less reactive ruthenocene needed balancing electrophilicity and stability catalysts. Various alkenes installed, allowing fine-tuning redox potentials.
e21017 Background: The anti-VEGF antibody, bevacizumab, has been FDA approved for the treatment of breast cancer. While germline variability (i.e. single nucleotide polymorphisms) may serve as a predictive marker therapy, to date tumor-specific not. More specifically, amplification or deletion VEGFA gene not studied evaluated prognostic biomarker Methods: A VEGFA/centromere enumerization-6 (CEN-6) probe was created and validated using DNA clones restriction enzyme fragment measurements....
Abstract Here, we show the conversion of unactivated alkenes into α‐branched enones via regioselective chloroacylation with acyl chlorides. The method relies upon initial in situ generation chlorine radicals directly from chloride precursor under cooperative nickel/photoredox catalysis. Subsequent HCl elimination provides and α,β‐unsaturated esters that are not accessible conventional acylation approaches provide other, linear constitutional isomer.
Abstract Introduction: HER2 assessment for selection of patients that may benefit from targeting treatment can be performed by either immunohistochemistry (IHC), fluorescence or chromogen in situ hybridization (FISH CISH). FISH is a robust and reliable technique direct visualization quantitative determination gene amplifications, deletions translocations human cancer cells, but protocols are time-consuming involve toxic reagents. By introducing new non-toxic ethylene carbonate based buffer...
Abstract Die im Poly(methylmethacrylat) (PMMA) und in chlorsubstituierten Poly(methacrylaten) radiolytisch erzeugten Radikale ergeben ähnliche EPR‐Neunlinienspektren. Molekülumwandlungen zur Deutung der quantitativ unterschiedlichen Akkumulationsprozesse werden diskutiert. EPR‐Spektren bei Heliumtemperaturen bestätigen die Hypothese Akkumulation von Allylradikalen PMMA.