A5077165427- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Caveolin-1 and cellular processes
- Electrolyte and hormonal disorders
- Ion channel regulation and function
- Reproductive System and Pregnancy
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- Gout, Hyperuricemia, Uric Acid
- Infant Nutrition and Health
- Parathyroid Disorders and Treatments
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Pituitary Gland Disorders and Treatments
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Diet and metabolism studies
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
University of Buenos Aires
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
University of Naples Federico II
2024
University of Turin
2024
Institute of Astronomy and Space Physics
2016-2021
Instituto de Química y Fisicoquímica Biológicas
2001-2020
Universidad de Sevilla
2015
Institute for Medical Research
2003-2005
Massachusetts General Hospital
2000
Harvard University
2000
Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is major cause autosomal dominant polycystic kidney disease (ADPKD), whose manifestation entails the development fluid-filled cysts target organs. Here, we demonstrate that polycystin-2 present term human syncytiotrophoblast, where it behaves as nonselective cation channel. Lipid bilayer reconstitution polycystin-2-positive syncytiotrophoblast apical membranes displayed channel with multiple subconductance...
We assessed the diagnostic utility of uric acid for prediction preeclampsia. An observational prospective approach was carried out during 2014. Preeclamptic women were classified into 4 groups accordingly to onset preeclampsia and presence intrauterine growth restriction (IUGR). Serum levels, urea, creatinine measured. Receiver operating curves (ROC) levels ratio (UAr) between a dosage before after 20th week gestation performed. One thousand two hundred ninety-third pregnant enrolled in this...
The cytolytic pore-forming protein (PFP, perforin) of lymphocyte granules has recently been isolated and characterized. lytic activities expressed by both the purified PFP require presence Ca2+. Here, we report on extracellular release after stimulation lymphocytes with Ca2+ ionophore A23187, which degranulates cells. secreted associates lipid to form structural functional channels supramolecular complexes that partially resist dissociation sodium dodecyl sulfate reducing agents. Immunoblots...
Are the placental aquaporins (AQPs) involved in apoptosis of human trophoblast?The general blocking AQPs with HgCl2 and, particular, AQP3 activity CuSO4 abrogated apoptotic events trophoblast cells.Although cells is a natural event normal development placenta, it exacerbated pathological processes, such as pre-eclampsia, where an abnormal expression and functionality occur without alterations feto-maternal water flux. Furthermore, fluctuations O2 tension are proposed to be potent inducer...
Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing incidence of complications both mother and fetus. The macrosomia that occurs these fetuses may be related with some changes nutrient transport mechanism placenta. presence aquaporin 9, an aquaglyceroporin, has previously been demonstrated We raised question whether 9 expression upregulated placenta from gestational diabetes, thus providing a faster glycerol water through studied 21...
The response of brain antioxidant system to the oxidative stress following Fe and Cu overloads involves: consumption an adaptive increase in enzyme activities protein expression.