A5103152081- Vacuum and Plasma Arcs
- Cutaneous Melanoma Detection and Management
- Electrical Fault Detection and Protection
- Nonmelanoma Skin Cancer Studies
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Micro and Nano Robotics
- Sirtuins and Resveratrol in Medicine
- Plant biochemistry and biosynthesis
- Electromagnetic Launch and Propulsion Technology
- Alzheimer's disease research and treatments
- Hippo pathway signaling and YAP/TAZ
- Nuclear Receptors and Signaling
- Microfluidic and Bio-sensing Technologies
- Gallbladder and Bile Duct Disorders
- Biochemical effects in animals
- Advanced biosensing and bioanalysis techniques
- Brain Tumor Detection and Classification
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- Advanced Nanomaterials in Catalysis
- Cutaneous lymphoproliferative disorders research
- Hand Gesture Recognition Systems
- Biological Activity of Diterpenoids and Biflavonoids
Fudan University
2025
Ningbo University
2022-2025
State Key Laboratory of Genetic Engineering
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
Shandong University of Traditional Chinese Medicine
2024
Northern Jiangsu People's Hospital
2023
Harbin Institute of Technology
2019-2022
Xintai People's Hospital
2022
Xian Yang Central Hospital
2022
Shanghai Children's Medical Center
2020
Use of artificial intelligence to identify dermoscopic images has brought major breakthroughs in recent years the early diagnosis and treatment skin cancer, incidence which is increasing year by worldwide poses a great threat human health. Achievements have been made research cancer image classification using deep backbone convolutional neural network (CNN). This approach, however, only extracts features small objects image, cannot locate important parts.As result, researchers paper turn...
Inspired by nature, innovative devices have been made to imitate the morphology and functions of natural red blood cells (RBCs). Here, we report a cell-mimetic micromotor (RBCM), which was fabricated based on layer-by-layer assembly method precisely controlled an external rotating uniform magnetic field. The main framework RBCM constructed protein zein finally camouflaged with RBC membrane. Functional cargos such as Fe3O4 nanoparticles chemotherapeutic agent doxorubicin were loaded within...
Alzheimer's disease (AD) is a neurodegenerative that remains challenging to treat. Akt and Wnt play role in complex cellular signaling, which crucial for examining the onset of AD. In this study, we aimed identify analyze pathway-related genes (ARGs) (WRGs) as AD biomarkers, determine effects ARGs WRGs on AD, verify these mouse models. We searched differentially expressed Gene Expression Omnibus database, constructed candidate gene protein–protein interaction networks, used least absolute...
The rising prevalence of skin lesions places a heavy burden on global health resources and necessitates an early precise diagnosis for successful treatment. diagnostic potential recent multi-modal lesion detection algorithms is limited because they ignore dynamic interactions information sharing across modalities at various feature scales. To address this, we propose deep learning framework, Multi-Modal Skin-Imaging-based Information-Switching Network (MDSIS-Net), end-to-end recognition....
Background Long-term exposure to air pollution and physical activity (PA) are linked blood pressure hypertension. However, the joint effect of PA on hypertension still unknown in Chinese middle-aged older adults. Methods A total 14,622 adults from China Health Retirement Longitudinal Study wave 3 were included this study. Ambient [particulate matter with diameter ≤ 2.5 μm (PM ), or ≤10 10 sulfur dioxide (SO 2 nitrogen (NO carbonic oxide (CO)] estimated using satellite-based spatiotemporal...
Pinecone is a traditional folk herb, which has been used in China for many years. In this paper, the essential oil from Pinus koraiensis pinecones (PEO) was obtained by hydrodistillation and 41 compounds were identified gas chromatography–mass spectrometry (GC-MS), mainly including α-Pinene (40.91%), Limonene (24.82%), β-Pinene (7.04%). The purpose of study to investigate anti-tumor activity PEO on MGC-803 cells its mechanism. Anti-tumor experiments vitro showed could significantly inhibit...
Abstract The proteasome inhibitor bortezomib is the most successfully applied chemotherapeutic drug for treating multiple myeloma. However, its clinical efficacy reduced due to resistance development. underlying molecular mechanisms of are poorly understood. In this study, by combining in silico analysis and sgRNA library based screening assay, we identified SENP2 ( Sentrin/SUMO-specific proteases-2 ) as a sensitive gene found expression highly downregulated resistant myeloma patient’s...
Essential oil is the natural extract rich in terpenoids, showing various physiological activities. Our previous studies have proved that essential of Pinus koraiensis pinecones (PEO) can inhibit proliferation MGC-803 cells and promote cell apoptosis vitro via HIPPO/YAP signaling pathway. In this study, we prepared PEO nanoemulsion studied its physicochemical properties anti-tumor activity tumor-bearing nude mice. The showed good stability, with an average particle size 46.87 nm, a zeta...
Micro/nanomotors (MNMs) have attracted tremendous interest of researchers owing to their ability mimic the function natural microorganisms complete tasks in biomedicine and other fields.
In this paper, dc arc characteristics in different high pressure gas atmospheres were studied, both pure N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and mixed gases of 20%N 80%H at 5 atm. The experiments conducted a demountable arc-quenching chamber with double contacts transparent glass shield 270 V circuit. With high-speed camera, the motion is analyzed. results indicate that H have better performance for extinguishing. Images...
In this paper, the characteristic of 270 V dc forcing interruption is studied. The experiments are performed on a synthetic test circuit, under 1400 and 2000 A current, with CuCr electrode vacuum interrupter. With fixed average current rate, di/dt, arc column shrinks in different situations. both experiments, diameter changes three phases. At beginning forcing, seems stable. Consider that thermal hysteresis plays an important role it. Then, decline. Finally, sharply decreases until quenched....
In recent years, skin lesion has become a major public health concern, and the diagnosis management of lesions depend heavily on correct segmentation lesions. Traditional convolutional neural networks (CNNs) have demonstrated promising results in segmentation, but they are limited their ability to capture distant connections intricate features. addition, current medical image algorithms rarely consider distribution different categories regions do not spatial relationship between pixels.
With the increased power capacity of more/all electric aircraft, current was up to hundreds amperes and supply voltage increased. Large interrupting capacity, compact size light weight are requirements aviation switch in future. According hydrogen has its own advantage weight, high speed molecular motion, thermal coefficient, strong deionization effect, which is helpful for extinguishing DC arc. In order confirm this, this paper, used arc-quenching medium, interruption experiments were...
The extracts of Pinus koraiensis pinecones have been proved to be highly cytotoxic tumor cells, with ambiguous material basis antitumor efficacy. In the present study, screening compounds activity was performed through successive applications various purification technologies, accompanied anticancer tracking. Futhermore, structures target molecules were confirmed. order obtain active compounds, lead compound dehydroabietic acid chemically modified into its hexamer (DD2) by a simple method...
Abstract Background Alzheimer's disease is a neurodegenerative that difficult to reverse. Akt and Wnt play role in complex cellular signaling, which important for studying the onset of AD. This study aimed screen key genes pathways as potential biomarkers early diagnosis treatment Methods We searched differentially expressed GEO database, constructed candidate gene protein-protein interaction (PPI) networks, used least absolute shrinkage selection operator (LASSO) regression analysis support...
<title>Abstract</title> Alzheimer’s disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis, comprising gene expression alterations and abnormal immune cell infiltration. In this study, we aimed at further exploring AD pathogenesis identifying potential therapeutic targets. We downloaded GSE181279 dataset-derived single-cell data from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, then processed analyzed it using various...
A large number of works have been made to apply P2P techniques into services discovery. However, most them only focus on matching the functional properties. This paper proposed a web QoS Model, which is based content addressable network. In this model, we use non-functional properties values match service, and service algorithm given out. We assign virtual weight reduce query cost some nodes since they receive more request. Experiments with real datasets show ectiveness scheme by comparing...