A5101522333- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Genomic variations and chromosomal abnormalities
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genomics and Chromatin Dynamics
- Topic Modeling
- Knowledge Management and Sharing
- Bipolar Disorder and Treatment
- Blind Source Separation Techniques
- Neural dynamics and brain function
- Ziziphus Jujuba Studies and Applications
- Image and Signal Denoising Methods
- Lipid Membrane Structure and Behavior
- Chromatin Remodeling and Cancer
- Ubiquitin and proteasome pathways
- Wikis in Education and Collaboration
- Plant Gene Expression Analysis
- Hemoglobinopathies and Related Disorders
- Calcium signaling and nucleotide metabolism
- Fungal and yeast genetics research
- Biomedical Text Mining and Ontologies
Fujian Agriculture and Forestry University
2025
Henan Psychiatric Hospital
2020-2022
Xinxiang Medical University
2016-2022
Second Xiangya Hospital of Central South University
2018-2021
Central South University
2018-2021
Peking University People's Hospital
2021
Peking University
2021
Science for Life Laboratory
2016-2018
Uppsala University
2016-2018
Kyushu University
2015
<h3>Background</h3> De novo mutations are a frequent cause of disorders related to brain development. We report the results screening patients diagnosed with both epilepsy and intellectual disability (ID) using exome sequencing identify known new causative de relevant these conditions. <h3>Methods</h3> Exome was performed on 39 patient–parent trios mutations. Clinical significance in genes determined American College Medical Genetics Genomics standard guidelines for interpretation coding...
BES1 (BRI1 EMS SUPPRESSOR 1) is a critical transcription factor involved in plant growth, development, and stress responses. Although genes have been characterized several species, their roles longan (Dimocarpus Lour.) remain unclear. This study identified analyzed eight the genome. Phylogenetic analysis classified these into four subgroups (I-IV), with conserved motifs intron–exon structures indicating potential functional similarities within subgroups. Cis-element revealed that promoters...
Intellectual Disability (ID) is a clinically heterogeneous condition that affects 2–3% of population worldwide. In recent years, exome sequencing has been successful strategy for studies genetic causes ID, providing growing list both candidate and validated ID genes. this study, was performed on 28 patients in 27 patient‐parent trios with the aim to identify de novo variants (DNVs) known novel associated We report identification 25 DNVs out which five were classified as pathogenic or likely...
Chromatin-remodeling factors are required for a wide range of cellular and biological processes including development cognition, mainly by regulating gene expression. As these functions would predict, deregulation chromatin-remodeling causes various disease syndromes, neurodevelopmental disorders. Recent reports have linked mutations in several genes coding to intellectual disability (ID). Here, we used exome sequencing identified nonsynonymous de novo mutation BAZ1A (NM_182648.2:c.4043T >...
Glycosylphosphatidylinositol (GPI) is a glycolipid that tethers more than 150 different proteins to the cell surface. Aberrations in biosynthesis of GPI anchors cause congenital disorders glycosylation with clinical features including intellectual disability (ID), seizures, and facial dysmorphism. Here, we present two siblings ID, cerebellar hypoplasia, ataxia, early-onset minor dysmorphology. Using exome sequencing, identified homozygous nonsense variant (NM_001127178.1:c.1640G>A,...
Abstract Background Brain anatomical deficits associated with cognitive dysfunction have been reported in patients schizophrenia. However, it remains unknown whether such exist individuals prodromal psychosis. The present study is designed to investigate and their associations clinical/cognitive features. Methods Seventy‐four seventy‐six healthy controls were scanned using structural magnetic resonance imaging. Support vector machines applied test might be used discriminate from controls....
Introduction: Affecting ~1% of the world population, schizophrenia is known as one costliest and most burdensome diseases worldwide. Antipsychotic medications are main treatment for to control psychotic symptoms efficiently prevent new crises. However, due poor compliance, 74% patients with discontinue medication within 1.5 years, which severely affects recovery prognosis. Through research on intra interindividual variability based a...
Efficient learning from Web resources can depend on accurately assessing the quality of each resource. We present a methodology for developing computational models that assist users in resources. The consists four steps: 1) meta-analysis previous studies to decompose into high-level dimensions and low-level indicators, 2) an expert study identify key indicators target domain, 3) human annotation provide collection example where presence or absence has been tagged, 4) training machine model...
Background: Anatomical and functional deficits in the cortico-limbic-cerebellar circuit are involved neurobiology of somatization disorder (SD). The present study was performed to examine causal connectivity related structural first-episode, drug-naive patients with SD at rest. Methods: A total 25 28 healthy controls underwent resting-state magnetic resonance imaging. Voxel-based morphometry Granger causality analysis were used analyze data. Results: Results showed that exhibited decreased...
Skp1 an essential component of the SCF (Skp1/cullin/F-box) E3 ubiquitin ligases, which target proteins for degradation by 26S proteasome. We generated a skp1dM mutant strain that is defective galactose induction GAL1 gene and we have found galactose-induced protein repressor Mig2 in this strain. was also abolished cells lacking kinase Snf1 F-box Das1, suggesting triggers SCFDas1. Chromatin immunoprecipitation showed associates with promoter upon exit Mig1 cells, but not wild-type conditional...
We present a new algorithm to measure domain-specific readability. It iteratively computes the readability of resources based on difficulty concepts and vice versa, in style reminiscent other bipartite graph algorithms such as Hyperlink-Induced Topic Search (HITS) Stochastic Approach for Link-Structure Analysis (SALSA). While simple, our outperforms standard heuristic measures remains competitive among supervised-learning approaches. Moreover, it is less domain-dependent portable across...
Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with somatization disorder (SD). However, changes anatomical specificity thalamo-cortical functional connectivity (FC) SD remain unclear.Resting-state fMRI scans were collected 25 first-episode, drug-naive patients SD, as well 28 sex-, age-, education-matched healthy controls. We parcellated seven predefined regions interest (ROIs) used them seeds map whole-brain FC. Correlation analysis was...
End-user trust has been increasingly recognized as important for successful management and use of web information systems (IS). This research investigates influential factors the establishment end-user toward IS. The theory reasoned action technology acceptance model are adopted theoretical foundation model. Based on analysis data collected from 88 participants an international coffee company, results reveal that perceived ease use, usefulness, user familiarity, system normality have...
Objective: To study the impairments of cognitive function in first-episode schizophrenia and potential effectiveness risperidone olanzapine monotherapy on schizophrenia. Methods: A total 57 30 healthy controls were assessed at baseline, patients again after 8-week antipsychotics therapy. Results: The positive negative symptom scale (PANSS) reductive ratio between two groups was similar. At performance significant poor than four domains (P<0.05); 8-week's therapy, Trail Making Test (t=3.862,...
The precise estimation of the frequency signal is great significance in many areas application. In this paper, a new algorithm for estimating one real tone noise from block N uniformly spaced samples proposed. This based on fundamental principle DFT. As stand-alone algorithm, estimator provides excellent performance but computation more complex comparatively when operate independently. can also cooperate with other estimators, which reduces computational complexity efficiently without reduction.
The nucleosomes occupying the chromosomal start sites of transcription contain histone H2A variant H2A.Z in place H2A. Upon galactose induction, are evicted from GAL1 locus Saccharomyces cerevisiae cells. (which is encoded by HTZ1 gene S. cerevisiae) required for eviction promoter nucleosome and transcriptional activation gene; however, histones also important repression we asked present paper if plays a role glucose promoter. With help fusion URA3 ORF (open reading frame) to promoter, were...
Objective To explore the characteristics of evoked potentials P300 and mismatched negativity (MMN) in treatment-refractory schizophrenia. Methods 21 schizophrenia patients as case group 26 healthy subjects normal control were measured events-related potential MMN, differences at F3, F4, Fz, Cz MMN Cz, Pz two groups compared. Results ① The reaction time group[(408.91±202.24) ms] was longer than group((361.60±254.32) ms), difference significant(P<0.05). ②P300 latency...