A5103136851- Protein Kinase Regulation and GTPase Signaling
- Oral microbiology and periodontitis research
- Cellular transport and secretion
- Metabolism, Diabetes, and Cancer
- Salivary Gland Disorders and Functions
- Cell Adhesion Molecules Research
- Synthesis and Catalytic Reactions
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Protease and Inhibitor Mechanisms
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Adipokines, Inflammation, and Metabolic Diseases
- DNA and Nucleic Acid Chemistry
- Bone Metabolism and Diseases
- Bone health and treatments
- Lipid Membrane Structure and Behavior
- Bone and Dental Protein Studies
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Proteoglycans and glycosaminoglycans research
- PI3K/AKT/mTOR signaling in cancer
Kyushu Dental University
2016-2025
Mitsui Memorial Hospital
2020-2022
Keio University
1963-2018
Takasaki University of Health and Welfare
2005-2018
Japanese Red Cross Nagoya Daini Hospital
2016-2018
Kyushu University
2005-2015
Nagoya City University
2001-2011
Asahi University
1991-2009
Sapporo Medical University
2001-2005
National Kinki Chuo Hospital for Chest Disease
2005
Background Matrix metalloproteinases (MMPs) that degrade the extracellular matrices (ECMs) have been thought to play an important role in both invasion and metastasis of tumors. However, detailed MMPs TIMPs (tissue inhibitors MMP) on biological behavior tumor cells has yet be elucidated vivo. The aim present study was thus determine whether expression is associated with such clinicopathological features as invasive metastatic potential. Materials Methods This included 96 cases primary oral...
Design : The aim of this study was to determine the association between aging and adiponectin level from aspect influence renal function sex hormones in humans. Methods Serum blood urea nitrogen (BUN) levels were measured 964 subjects (372 males) aged 60.3±12.5 years. Testosterone free testosterone 123 males, estrone estradiol 114 females. divided into two age groups; 65 years or older (Age ≥65 group) less than <65 group). Results Adiponectin increased linearly with whereas it...
The uncarboxylated form (ucOC), but not the γ-carboxylated (GlaOC), of bone-derived protein osteocalcin stimulates insulin secretion and regulates energy metabolism in target tissues. Glucagon-like peptide-1 (GLP-1) is an secretagogue that released from gut response to food intake. We have now found Gprc6a, a putative ucOC receptor, expressed epithelial cells mouse small intestine as well STC-1 enteroendocrine cells. Secretion GLP-1 by was stimulated GlaOC. serum concentration mice increased...
Background. Depression is a remitting but recurring disease. However, there paucity of prospectively recorded data on the course depression after recovery. Method. A multi-centre prospective serial follow-up study an inception cohort hitherto untreated unipolar major ( N =95) for 6 years. We report time to recurrence recovery from index depressive episode and their predictors. Results. The cumulative probability remaining well without subthreshold symptoms was 57% (95% CI, 46 68%) at 1 year,...
To screen 16 isoflavonoids isolated from Erythrina variegata (Leguminosae) for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).The roots of E. were macerated with acetone. The chloroform-soluble fraction the residue was subjected to repeated silica gel column chromatography followed by elution various solvents. Structures compounds determined extensive spectroscopic studies. Each compound dissolved in dimethyl sulphoxide and added agar plates (final...
Abstract Purpose: Recently, somatic mutations of the epidermal growth factor receptor (EGFR) gene were found in ∼25% Japanese lung cancer patients. These EGFR are reported to be correlated with clinical response gefitinib therapy. However, DNA sequencing using PCR methods described date is time-consuming and requires significant quantities DNA; thus, this existing approach not suitable for a routine pretherapeutic screening program. Experimental Design: We have genotyped mutation status...
Abstract Since several anti‐cancer drugs interact with cell membrane lipids, the effects of dietary factors on liposomal membranes different lipid composition were comparatively studied by measuring fluorescence polarization. Fluidity was imparted both hydrophobic and hydrophilic regions bilayers decreasing cholesterol increasing unsaturated phosphatidylcholine in membranes. At 0.625‐10 μM, (‐)‐epigallocatechin gallate, genistein, apigenin, resveratrol a reference drug, doxorubicin,...
Bone morphogenic proteins (BMPs) stimulate bone formation in vivo and osteoblast differentiation vitro via a Smad signaling pathway. Recent findings revealed that the activation of nuclear factor-κB (NF-κB) inhibits BMP-induced differentiation. Here, we show NF-κB BMP by directly targeting A selective inhibitor classic pathway, BAY11–770682, enhanced BMP2-induced ectopic vivo. In mouse embryonic fibroblasts (MEFs) prepared from mice deficient p65, main subunit NF-κB, BMP2, induced...
Abstract The uncarboxylated form of osteocalcin (GluOC) regulates glucose and lipid metabolism in mice. We previously showed that low-dose (≤10 ng/ml) GluOC induces the expression adiponectin peroxisome proliferator-activated receptor γ (PPARγ) via a cAMP–PKA–ERK–CREB signaling pathway 3T3-L1 adipocytes. also noticed high-dose (≥20 inhibits PPARγ these cells. have here explored mechanism underlying effects GluOC. High-dose triggered morphological changes adipocytes suggestive induction cell...
The protein p130 was originally isolated from rat brain as an inositol 1,4,5-trisphosphate-binding with a domain organization similar to that of phospholipase C-δ1 but which lacks C activity. Yeast two-hybrid screening human cDNA library for clones encode proteins interact has now led the identification catalytic subunit phosphatase 1α (PP1cα) p130-binding protein. association between and PP1cα also confirmedin vitro by overlay assay, "pull-down" surface plasmon resonance analysis....
Interleukin-1α(IL-1α) stimulates the production of prostaglandin E 2 (PGE ) in odontogenic keratocyst fibroblasts. However, signaling pathways remain obscure. In this study, we investigated IL-1αsignaling that regulate cyclooxygenase-2 (COX-2) expression IL-1αincreased COX-2 mRNA and protein, PGE secretion phosphorylation extracellular signal-regulated protein kinase-1/2 (ERK1/2), p38 mitogen-activated kinase (MAPK), c-Jun N-terminal (JNK). PD-98059, SB-203580, SP-600125, PDTC—which are...