A5026645974- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Bone Tumor Diagnosis and Treatments
- Protease and Inhibitor Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Bone health and treatments
- MicroRNA in disease regulation
- Ear and Head Tumors
- Oral health in cancer treatment
- Tumors and Oncological Cases
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
Fukuoka Dental College
2015-2025
Kumamoto University
2010-2014
Kyushu University
1996-2004
Okayama University
2000
Background Matrix metalloproteinases (MMPs) that degrade the extracellular matrices (ECMs) have been thought to play an important role in both invasion and metastasis of tumors. However, detailed MMPs TIMPs (tissue inhibitors MMP) on biological behavior tumor cells has yet be elucidated vivo. The aim present study was thus determine whether expression is associated with such clinicopathological features as invasive metastatic potential. Materials Methods This included 96 cases primary oral...
The peptides derived from ideal cancer-testis antigens, including LY6K, CDCA1, and IMP3 (identified using genome-wide cDNA microarray analyses), were used in immunotherapy for head neck squamous cell cancer (HNSCC). In this trial, we analyzed the immune response to safety efficacy of vaccine therapy.A total 37 patients with advanced HNSCC enrolled trial peptide therapy, OS, PFS, immunologic evaluated enzyme-linked ImmunoSpot (ELISPOT) pentamer assays. subcutaneously administered weekly IFA....
In promoting tumour malignancy IL-6 signalling is considered to have an important role. However, the biological roles of on radiosensitivity in oral squamous cell carcinoma (OSCC) remain largely unclear. The objective this study determine effects and molecular mechanisms OSCC.Two OSCC lines, tissue samples with radioresistant cells were used. We examined IL-6, or tocilizumab, a humanised anti-human receptor antibody, both DNA damage after X-ray irradiation vitro. addition, we investigated...
The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its significance oral squamous cell carcinoma (OSCC) not been fully explored. purpose this study was determine the clinical NLR OSCC. OSCC who underwent surgery following 5-fluorouracil (5-FU)-based chemoradiotherapy were enrolled study. associations between status and various clinicopathological features examined, effects on prognosis evaluated. Analysis circulating interleukin-6...
Necrotizing sialometaplasia (NSM) is a non-neoplastic lesion listed in the WHO classification of Head and Neck Tumours. In early NSM lesion, there infarction necrosis acinar cells squamous metaplasia salivary ducts occurs as matures. Differentiation from cell carcinoma other malignancies sometimes required clinically histopathologically. Local hypoxia caused by trauma vascular compromise proposed etiology NSM. However, mechanisms underlying pathogenesis are unclear. This study focused on...
Reduction or loss of the intercellular junctions known as desmosomes may contribute to invasive and metastatic behaviour various carcinomas. Previous studies have shown that metastasis oral squamous cell carcinomas head neck correlates with a reduction in immunohistochemical staining for desmoplakin desmoglein at invasion front. The primary aim present study was extend these observations include third component desmosomes, glycoprotein desmocollin. An additional determine whether...
The tumor-associated microenvironment has been shown to protect tumor cells from treatment, and the extracellular matrix (ECM) is known affect drug resistance as a key regulator of microenvironment. However, little about cell adhesion-mediated (CAM‑DR) due cell-ECM contact in patients with oral squamous carcinoma (OSCC). In present study, we evaluated ECM molecule fibronectin (FN) using DNA microarray data obtained parental 5-FU-resistant OSCC lines. We investigated effects adhesion FN on...
The highly malignant phenotype of oral squamous cell carcinoma (OSCC), including the presence nodal and distant metastasis, reduces patient survival. High-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that involved in advanced phenotypes poor prognosis several human cancers. However, its biological role OSCC remains to be elucidated. purpose this study was determine clinical significance HMGA2 potential OSCC. We first investigated expression pattern relevance 110...
It has been increasingly recognized that the tumour microenvironment is a critical factor involved in cancer progression. However, little known about clinical value of stromal features oral squamous cell carcinoma (OSCC). The purpose this study was to determine significance cancer-associated fibroblasts (CAFs) and tumour-associated macrophages (TAMs) OSCC. OSCC specimens were obtained from 60 patients who underwent surgery following 5-fluorouracil-based chemoradiotherapy. Paraffin-embedded...
MicroRNAs are a class of small, endogenous, noncoding 18- to 24-nucleotide-long RNAs that can regulate multiple processes related cancer progression. However, their clinical value in patients with oral squamous cell carcinoma has not yet been fully explored. Therefore, the aim this study was investigate significance circulating microRNAs patients. The expression levels miR-1246 and miR-1290 healthy volunteers were examined by quantitative real-time polymerase chain reaction. both...
Abstract Background Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines facilitates transcription. BRD4 been implicated in proliferation, metastasis, prognosis several types of cancer. However, the role OSCC remains to be elucidated. Methods We investigated utility as therapeutic target OSCC. Results JQ1, inhibitor,...
Pretreatment nutritional and immunological status is useful for predicting survival outcomes various types of malignant tumors. Our objective was to determine the impact pretreatment Onodera's prognostic index (OPNI) on patients who underwent definitive chemoradiotherapy advanced oral squamous cell carcinoma (OSCC). We reviewed 47 treated OSCC with (CRT) at our institution between January 2004 December 2011. determined OPNI according following formula: 10 × serum albumin (g/dL) + 0.005 total...
Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed death-1, an immunocyte co-receptor, resulting evasion from the immune system. Chemotherapeutic drugs have been recently reported induce expression of PD-L, such as PD-L1, some cancer cells. However, little is known regarding PD-L2 and its role oral squamous carcinoma (OSCC). In this study, we examined effect cisplatin on regulation OSCC lines analyzed malignant behavior PD-L2-expressing using...
Nucleostemin (NS) is essential for the maintenance of stem cell properties, functions which remain poorly understood in cancer cells. The purpose this study was to explore impact NS on malignancy and its clinical significance oral squamous carcinoma (OSCC) patients.We investigated effects proliferation invasion OSCC using NS-overexpressing or -knockdown We assessed activation STAT3 (signal transducer activator transcription 3) signalling pathway downstream targets cells with different...
Ameloblastoma (AB) is the most common benign epithelial odontogenic tumor occurring in jawbone. AB a slowly growing but sometimes shows locally invasive and an aggressive growth pattern with marked bone resorption. In addition, local recurrence distant metastasis of also occurs, which resembles one typical malignant potentials. From these points view, to understand better mechanisms cell migration or invasion necessary for clinical therapy improvements patients' quality life. Microtubules...
Nuclear factor-κB (NF-κB) activation contributes to the development of metastasis, thus leading a poor prognosis in many cancers, including OSCC. However, little vivo experimental data are available about effects NF-κB inhibition on OSCC metastasis. sublines were established from GFP-expressing parental cell line, GSAS, and designated GSAS/N3 N5 according passage number after cervical lymph node metastasis by serial orthotopic transplantation model. In vitro migration invasion assessed these...
Background The deregulation of microRNA (miRNA) is associated with multiple processes involved in cancer progression. RN ase III endonucleases, Dicer and Drosha, are key enzymes for mi RNA biogenesis, it has been reported that altered expressions these molecules affect the clinical outcomes patients various cancers. However, value measuring levels Drosha oral squamous cell carcinoma ( OSCC ) unclear. purpose this study was to determine significance . Methods Oral specimens were obtained from...
Abstract We investigated the involvement of hepatocyte growth factor (HGF) in salivary gland (SG) branching morphogenesis. The mouse submandibular (SMG) starts to develop at embryonic day 11.5–12 (E11.5–E12), and morphogenesis occurs area between mandibular bone tongue E14 E16.5. Real‐time reverse transcriptase‐polymerase chain reaction showed that expression c‐met /HGF receptor gene SMG increased peaked E16.5, concomitant with epithelial branching, high levels HGF mRNA were detected...
Abstract Oral leukoplakia ( OL ) is a common, potentially malignant disorder of the oral cavity. SMAD 4 was initially identified as tumor suppressor and central mediator transforming growth factor TGF )‐ β signaling. In this study, we aimed to determine expression patterns in , its relationship with degree inflammation, clinical implications biomarker for transformation. A total 150 patients were enrolled study. Paraffin‐embedded sections obtained from biopsy or resection specimens subjected...
Many attempts have been made to identify the risk factors for postoperative delirium, but this has proved difficult due its complex morbidity. Furthermore, there is little information on delirium in patients undergoing tumor resection and reconstructive surgery oral cancer. The aim of current study was investigate incidence present included 104 with pedicle or free flap reconstruction. Postoperative developed 22 (21.2%) these patients. mean time onset 2.5±1.0 days duration 1.9±1.2 days....