A5056988834- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced X-ray and CT Imaging
- Pain Management and Opioid Use
- MRI in cancer diagnosis
- Ear and Head Tumors
- Esophageal Cancer Research and Treatment
- Radiation Therapy and Dosimetry
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Lung Cancer Research Studies
- Advanced MRI Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
Nagasaki University
2023-2025
Kameda Medical Center
2025
Nagasaki University Hospital
2024-2025
Kumamoto University
2012-2024
Kumamoto University Hospital
2014-2023
Keio University
2019
University of Wisconsin–Madison
2016-2017
National Institute of Technology, Miyakonojo College
2008-2010
Kumamoto City Hospital
2009
Saiseikai Kumamoto Hospital
2008
To assess the utility of both minimum apparent diffusion coefficients (ADCs) and ADC difference values for grading astrocytic tumors at magnetic resonance imaging.The hospital's institutional review board approved this retrospective study waived informed consent. Fifty patients (23 male patients, 27 female patients; median age, 53 years) with newly diagnosed were evaluated. Two observers blinded to clinical information independently measured ADCs by manually placing three five regions...
Although the prognostic value of perfusion MR imaging in various gliomas has been investigated, that high-grade astrocytomas alone not fully evaluated. The purpose this study was to evaluate retrospectively whether tumor maximum relative cerebral blood volume (rCBV) on pretreatment is patients with astrocytoma.Between January 1999 and December 2002, 49 (30 men, 19 women; age range, 23-76 years) supratentorial astrocytoma underwent before inception treatment. patient age, sex, symptom...
In promoting tumour malignancy IL-6 signalling is considered to have an important role. However, the biological roles of on radiosensitivity in oral squamous cell carcinoma (OSCC) remain largely unclear. The objective this study determine effects and molecular mechanisms OSCC.Two OSCC lines, tissue samples with radioresistant cells were used. We examined IL-6, or tocilizumab, a humanised anti-human receptor antibody, both DNA damage after X-ray irradiation vitro. addition, we investigated...
For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether at the simulation represents during SBRT, estimated inter- intrafractional changes patients undergoing SBRT. Ten underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided SBRT with abdominal compression (AC) fiducial markers. 4D-CBCT was performed to evaluate simulation, pre-, post-SBRT. The...
Abstract Despite advancements in treatments, oral squamous cell carcinoma (OSCC) has not significantly improved prognosis or survival rate primarily due to the presence of treatment‐resistant OSCC. The intercellular communication between tumour cells is a molecular mechanism involved acquiring OSCC treatment resistance. Extracellular vesicles (EVs) and encapsulated miRNAs are important mediators communication. Here, we focused on EVs released from clinically relevant radioresistant (CRR)...
Nuclear factor erythroid 2-related 2 (Nrf2), which regulates the expression of critical antioxidant proteins, was recently demonstrated to play a key role in cancer progression. Resistance radiotherapy is major obstacle treating oral squamous cell carcinoma (OSCC). However, little known about association between Nrf2 and radioresistance OSCC. Two OSCC lines (SAS HSC-2) their clinically relevant radioresistant (CRR) clones (SAS-R, HSC-2-R) were used. The effects downregulation on...
Radioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) lines generated by irradiating parental cells over time, which are useful for OSCC research. In present study, conducted gene expression analysis using CRR and their investigate regulation radioresistance in cells. Based on changes time subjected irradiation, forkhead box M1 (FOXM1) was selected further...
Solitary fibrous tumors (SFT) are rare, and their intraocular occurrence is extremely uncommon. Therefore, magnetic resonance imaging (MRI) reports of SFT limited, making preoperative diagnosis difficult. We present a case primary choroidal explore dynamic contrast-enhanced (DCE) MRI findings along with histopathological findings. This investigation expected to improve our understanding the SFT. An 83-year-old woman presented decreased vision in her right eye for several months. Computed...
ABSTRACT Background and Purpose Sepsis can cause sepsis‐associated encephalopathy resulting disorder of consciousness, with small hemorrhagic lesions visible in SWI. We aimed to investigate the clinical significance these lesions, termed multiple SWI low signal intensities, patients encephalopathy. Methods retrospectively examined scans 107 patients, whom 18 had intensities on MRI 89 did not. then compared data between two patient groups. Furthermore, we scored numbers (0 lesions: 0 points;...
Introduction: Synchronous cancer, which is when a secondary cancer occurs simultaneously or within six months of primary diagnosis, rare for malignant female genital tract neoplasms. Despite cervical and endometrial cancers being very common gynecologic malignancies, they do not frequently occur synchronously. Case Report: Here, we report case 49-year-old patient with synchronous occurrence adenocarcinoma carcinosarcoma (CCS), an extremely aggressive subtype. Transvaginal ultrasonography...
Introduction Mycobacterium avium complex pulmonary disease (MAC-PD) necessitates prolonged treatment. However, determining the appropriate time to conclude treatment is challenging because of lack indices for evaluating activity. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can be used visualize inflammatory sites and hypothesized indicate efficacy in diseases. Therefore, we conducted this single-arm, open-label, interventional study investigate utility...
On contrast-enhanced magnetic resonance (MR) images, pilocytic astrocytomas (PAs) are usually well-enhanced tumors that may mimic high-grade gliomas (HGGs). the other hand, it has been suggested areas exhibiting minimum apparent diffusion coefficient (ADC) values reflect sites of highest cellularity within heterogeneous tumors.To test hypothesis PAs is significantly different to HGGs, which should result in significant differences ADC values.Between 1999 and 2005, 15 patients (nine males,...
To evaluate whether saliva production reflects the parotid volume during course of radiation therapy (RT) in patients with head-and-neck cancer.Twenty advanced oral squamous cell carcinomas, who were treated preoperative chemo-RT, underwent morphological assessment CT or MRI and functional Saxon test. For test, was measured by weighing a gauze pad before 2 min after chewing without swallowing; low-normal value is g. Saliva volumes weeks RT compared paired t-test, Spearman rank correlation...
Aim: Our study sought to identify dosimetric predictors of treatment-related lymphopenia during chemoradiotherapy for esophageal cancer. Materials and Methods: Patients with cancer who had received definitive at our Institution were retrospectively assessed. The absolute volume the spleen, body, bone marrow that 5, 10, 20, 30 Gy mean splenic dose recorded. Results: Multivariate linear regression analysis revealed docetaxel use spleen dose–volume parameters (V5, V10, V20, V30, dose)...
MicroRNAs are a class of small, endogenous, noncoding 18- to 24-nucleotide-long RNAs that can regulate multiple processes related cancer progression. However, their clinical value in patients with oral squamous cell carcinoma has not yet been fully explored. Therefore, the aim this study was investigate significance circulating microRNAs patients. The expression levels miR-1246 and miR-1290 healthy volunteers were examined by quantitative real-time polymerase chain reaction. both...
Abstract Background To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC). Methods Thirty-four consecutive patients with HNC were treated at least one cycle RTOG regimen. Treatment plans included use VMAT 6 MV photons generated by linear accelerator. Two daily fractions 3.7 Gy delivered an interval h 2 days, totaling 14.8 over 4 fractions....
Pretreatment nutritional and immunological status is useful for predicting survival outcomes various types of malignant tumors. Our objective was to determine the impact pretreatment Onodera's prognostic index (OPNI) on patients who underwent definitive chemoradiotherapy advanced oral squamous cell carcinoma (OSCC). We reviewed 47 treated OSCC with (CRT) at our institution between January 2004 December 2011. determined OPNI according following formula: 10 × serum albumin (g/dL) + 0.005 total...
<b>BACKGROUND AND PURPOSE:</b> Differentiation between paraclinoid and cavernous sinus aneurysms of the internal carotid artery (ICA) is critical when considering treatment options. The purpose this study was to determine whether contrast-enhanced (CE) 3D constructive interference in steady state (CISS) MR imaging useful differentiate aneurysms. <b>MATERIALS METHODS:</b> This included 11 10 consecutive female patients, ranging from 52 66 years age. All were adjacent anterior clinoid process....
Although gross tumor volume (GTV) at the primary site can predict local control of head-and-neck squamous cell carcinoma (SCC) in patients who are treated with organ-preservation therapy, GTV assessment does not eliminate substantial interobserver variation.To evaluate whether F-18-fluorodeoxyglucose positron emission tomography (FDG-PET)/computed (CT) fused imaging provides additional information for assessment.We obtained FDG-PET/CT images on 20 SCC. All had undergone preoperative...