A5042570402- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Neuropeptides and Animal Physiology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemical Synthesis and Analysis
- Radiation Detection and Scintillator Technologies
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Receptor Mechanisms and Effects
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Estrogen and related hormone effects
- Vascular Tumors and Angiosarcomas
- Hypothalamic control of reproductive hormones
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Effects and risks of endocrine disrupting chemicals
- Radiation Effects and Dosimetry
- Traditional and Medicinal Uses of Annonaceae
Kumamoto University Hospital
2014-2024
Kumamoto Health Science University
2012-2017
Kumamoto University
2011-2017
Kumamoto Orthopedic Surgery Hospital
2011-2013
Kyushu University
1990-2010
Fukuoka University
2009
National Institutes of Health
1982-1985
Institute of Art
1985
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1985
National Institute of Diabetes and Digestive and Kidney Diseases
1985
Chemical deglycosylation of purified human chorionic gonadotropin (hCG) was performed by treatment with anhydrous HF in the presence anisole at 0 "C for 1 h.Gel chromatography product on Sephadex G-100 revealed a single peak Kav = 0.28, as compared to 0.21 intact hCG.Subunit dissociation less than 5%. Sodium dodecylsulfate-gel electrophoresis pooled peak, denoted HF-hCG, showed two bands molecular sizes 30% lower native and P subunits.No change amino acid composition detected, but...
Estrogen-related receptor γ (ERRγ), one of the 48 human nuclear receptors, has a fully active conformation with no ligand. We recently demonstrated that ERRγ binds strongly bisphenol A (BPA), nastiest endocrine disruptors, and thus retaining ERRγ's high basal constitutive activity. report BPA accumulates in maternal–fetal placental unit led us to hypothesize large amount might exist placenta. Here we evidence placenta indeed expresses exceptionally strongly. first ascertained presence nine...
The balance between androgens and estrogens is very important in the development of prostate, even small changes estrogen levels, including those estrogen-mimicking chemicals, can lead to serious changes. Bisphenol A (BPA), an endocrine-disrupting chemical, a well-known, ubiquitous, estrogenic chemical. To investigate effects fetal exposure low-dose BPA on we examined alterations situ sex steroid hormonal environment mouse urogenital sinus (UGS). In BPA-treated UGS, estradiol (E2) levels...
For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether at the simulation represents during SBRT, estimated inter- intrafractional changes patients undergoing SBRT. Ten underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided SBRT with abdominal compression (AC) fiducial markers. 4D-CBCT was performed to evaluate simulation, pre-, post-SBRT. The...
We measured the angular dependence of central and off-axis detectors in a 2D ionization chamber array, MatriXX, applied correction factors (CFs) to improve accuracy composite dose verification IMRT VMAT. The MatriXX doses were with 10° step for gantry angles (θ) 0°-180°, 1° lateral 90°-110° phantom, 30 × 10 cm2 field 6 MV photons. also calculated under same conditions by Monte Carlo (MC) algorithm. CFs obtained as function θ from ratios MatriXX-measured MC-calculated doses, normalized at =...
Abstract Introduction Due to its spherical surface, scalp angiosarcoma requires careful consideration for radiation therapy planning and dose delivery. Herein, we investigated whether volumetric modulated arc (VMAT) is superior intensity (IMRT) in terms of the plan quality delivery time. Methods Three different coplanar treatment plans were created four patients, comprising a two‐arc VMAT as well 5‐field 9‐field IMRT with 6 MV beams. The X‐ray Voxel Monte Carlo algorithm was employed...
Intensity-modulated radiation therapy is being increasingly used to treat cervical esophageal cancer (CEC); however, delineating the gross tumor volume (GTV) accurately essential for its successful treatment. The use of computed tomography (CT) images determine GTV produces a large degree interobserver variation. In this study, we evaluated whether [18F]-fluoro-2-deoxy-D-glucose positron emission (FDG-PET)/CT fused reduced variation, compared with CT alone, in patients CEC. FDG-PET/CT scans...
In this study, we evaluated the performance of a three‐dimensional (3D) dose verification system, COMPASS version 3, which has dedicated beam models and calculation engine. It was possible to reconstruct 3D distributions in patient anatomy based on measured fluence using MatriXX 2D array. The system compared with Monte Carlo simulation (MC), glass rod dosimeter (GRD), 3DVH, an anthropomorphic phantom for intensity‐modulated radiation therapy (IMRT) clinical neck cases. GRD measurements...
This study investigated the accuracy of positioning and irradiation targeting for multiple off-isocenter targets in intracranial image-guided radiation therapy (IGRT). A phantom with nine circular was created to evaluate both accuracies. First, central point isocenter target positioned a combination an ExacTrac x-ray (ETX) 6D couch. The determined from deviations coordinates each obtained kV-cone beam computed tomography (kV-CBCT) IGRT planning CT. Similarly, evaluated between multi-leaf...
Abstract Stereotactic body radiation therapy ( SBRT ) involves the delivery of substantially larger doses over fewer fractions than conventional therapy. Therefore, treatments will strongly benefit patients using vivo patient dose verification, because impact fraction is large. For in measurements, a commercially available quality assurance QA system COMPASS IBA Dosimetry, Germany). uses new transmission detector (Dolphin, Dosimetry). In this study, we evaluated method for 3D reconstruction...
To evaluate the impact of 99mTc-labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) image-guided inverse planning on dose-function histogram (DFH) parameters for stereotactic body radiation therapy in patients with hepatocellular carcinoma (HCC).Eleven were enrolled this study. The functional liver structure (FLS) was derived from SPECT thresholds 60% to 80% maximum pixel value. Two treatment plans optimized...
Abstract Background Radiotherapy of gastric mucosa-associated lymphoid tissue (MALT) lymphoma should be delivered to the entire stomach with planning target volume (PTV) that accounts for variations in volume, respiratory movement, and patient set-up error. In this study, we evaluated whether use four-dimensional cone-beam computed tomography (4D-CBCT) reduces PTV. Methods Eight patients underwent radiotherapy 15 fractions MALT using 4D-CBCT. PTV structures 5–30 mm margins (5 intervals) from...
Background/Aim: We evaluated the influence of previous treatments on parametric discrepancies between dose–volume histograms (DVHs) and dose–function (DFHs) generated based <sup>99m</sup>Tc-GSA SPECT images hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRT). Patients Methods: Twelve underwent SBRT at 30-40 Gy. Registration planning CT SPECT/CT was performed, DFH parameters were calculated as follows: Fx=(sum counts within liver volume receiving a...
Background/Aim: To evaluate the utility of high spatial resolution digital positron emission tomography images with source-to-background ratio (SBR) algorithm for gross tumour volume (GTV) delineation. Materials and Methods: The bowl spheres (10-37 mm) were filled fluoro-2-deoxy-D-glucose to achieve 4-16 times background radioactivity. reconstructed using three isotropic voxel sizes. SBR percentage threshold (TH) SUV<sub>max</sub> calculated. plots between TH fitted a regression equation....
The purpose of this study was to evaluate a single-scan protocol using Gafchromic EBT3 film (EBT3) by comparing it with the commonly used 24-hr measurement for radiochromic dosimetry. Radiochromic is generally scanned 24 hr after exposure (24-hr protocol). enables results within short time only verification film, one calibration and unirradiated film. 30 min irradiation. curves were obtained multichannel dosimetry method. dose verifications each performed step pattern, pyramid clinical...
We compared three-dimensional conformal RT (3D-CRT), intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma using four-dimensional computed tomography (4D-CT) images.Three treatment plans of 3D-CRT, IMRT, VMAT with 30 Gy were created based on 4D-CT images seven patients. calculated D95, homogeneity index (HI), conformity (CI) planning target volume, organs at risk doses.There was no significant...