A5073414164- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Multiple Sclerosis Research Studies
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Peripheral Neuropathies and Disorders
- Neurological Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Protein Kinase Regulation and GTPase Signaling
- Protein Tyrosine Phosphatases
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
Centro de Biología Molecular Severo Ochoa
2020-2024
Universidad Autónoma de Madrid
2020-2024
Consejo Superior de Investigaciones Científicas
2020-2021
Brain ischemia, also known as ischemic stroke, occurs when there is a lack of blood supply into the brain. When an insult appears, both neurons and glial cells can react in several ways that will determine severity prognosis. This high heterogeneity responses has been major obstacle developing effective treatments or preventive methods for stroke. Although white matter pathophysiology not deeply assessed its remodelling greatly influence clinical outcome disability degree. Oligodendrocytes,...
Abstract In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain generation of new neurons that integrate into existing circuits. A reduction neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation proliferation survival NSCs have been hypothesized be at origin glioma. Thus, unravelling molecular underpinnings regulated activation must undergo proliferate generate progeny considerable relevance. Current research has identified...
Fast synaptic transmission in vertebrates is critically dependent on myelin for insulation and metabolic support. Myelin produced by oligodendrocytes (OLs) that maintain multilayered membrane compartments wrap around axonal fibers. Alterations myelination can therefore lead to severe pathologies such as multiple sclerosis. Given hypomyelination disorders have complex etiologies, reproducing clinical symptoms of diseases from a neurological perspective animal models has been difficult. We...
In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted that MOLs heterogeneous; however, how MOL subpopulations specified balanced in physiological settings is poorly understood. Previous works demonstrated an essential role small GTPases R-Ras1 R-Ras2...
Since the optic nerve is one of most myelinated tracts in central nervous system (CNS), many myelin diseases affect visual system. In this sense, our laboratory has recently reported that GTPases R-Ras1 and R-Ras2 are essential for oligodendrocyte survival maturation. Hypomyelination produced by absence or both proteins triggers axonal degeneration loss motor function. However, little known about R-Ras specificity other possible roles they could play CNS. work, we describe how a lack and/or...
ABSTRACT In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain generation of new neurons that integrate into existing circuits. A reduction neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation proliferation survival NSCs have been hypothesized be at origin glioma. Thus, unravelling molecular underpinnings regulated activation must undergo proliferate generate progeny considerable relevance. current research has identified...