A5072582600- Cancer Genomics and Diagnostics
- Nonmelanoma Skin Cancer Studies
- Immunotherapy and Immune Responses
- biodegradable polymer synthesis and properties
- Single-cell and spatial transcriptomics
- Electrospun Nanofibers in Biomedical Applications
- Physiological and biochemical adaptations
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
- Calcium Carbonate Crystallization and Inhibition
- Tissue Engineering and Regenerative Medicine
- Polar Research and Ecology
- Microbial Metabolites in Food Biotechnology
- Acute Myeloid Leukemia Research
- Plant nutrient uptake and metabolism
- Enzyme Production and Characterization
University of Otago
2008-2021
Significance Triple-negative breast cancer (TNBC) is the most aggressive subtype. Despite extensive genome-sequencing efforts, there still an incomplete understanding of genetic networks driving TNBC. Here, we used Sleeping Beauty transposon mutagenesis to identify genes that cooperate with mutant P ten in induction We identified 12 candidate TNBC trunk drivers and a larger number progression genes. Subsequent functional validation studies eight human tumor suppressor genes, including...
The systematic identification of genetic events driving cellular transformation and tumor progression in the absence a highly recurrent oncogenic driver mutation is challenge cutaneous oncology. In squamous cell carcinoma (cuSCC), high UV-induced mutational burden poses hurdle to achieve complete molecular landscape this disease. Here, we utilized Sleeping Beauty transposon mutagenesis system statistically define drivers keratinocyte cuSCC vivo UV-IR, identified both known suppressor genes...
Abstract The systematic identification of genetic events driving cellular transformation and tumor progression in the absence a highly recurrent oncogenic driver mutation is challenge cutaneous oncology. In squamous cell carcinoma (cuSCC), high UV-induced mutational burden poses hurdle to achieve complete molecular landscape this disease. Here, we utilized Sleeping Beauty transposon mutagenesis system statistically define drivers keratinocyte cuSCC vivo UV-IR, identified both known...