A5015569287- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Peroxisome Proliferator-Activated Receptors
- Alkaline Phosphatase Research Studies
Universidade Nova de Lisboa
2022-2023
BACKGROUND/OBJECTIVES: Indole-3-propionic acid (IPA) is a tryptophan-derived microbial metabolite that has been associated with protective effects against inflammatory and metabolic diseases.However, there lack of knowledge regarding the IPA under physiological conditions at intestinal level.MATERIALS/METHODS: Human epithelial Caco-2 cells were treated for 2, 24, and/ or 72 h its precursors -indole, tryptophan, propionate -at 1, 10, 100, 250, 500 μM to assess cell viability, integrity,...
Although elevated blood levels of trimethylamine N -oxide (TMAO) have been associated with atherosclerosis development in humans, the role its gut microbiota-derived precursor, TMA, this process has not yet deciphered. Taking into account, and fact that increased intestinal fatty acid absorption contributes to onset progression, study aimed evaluate effect TMA on a cell line mimics human enterocytes. Caco-2 cells were treated 250 μM for 24 h. Fatty was assessed by measuring...