A5047379618- RNA Research and Splicing
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Glycosylation and Glycoproteins Research
- Cellular transport and secretion
- Sarcoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
University of Liège
2015-2021
Centre National pour la Recherche Scientifique et Technique (CNRST)
2013
Université de Lille
2013
Centre National de la Recherche Scientifique
2013
Lipid microdomains (rafts) are cholesterol-enriched dynamic ordered lipid domains belonging to cell membranes involved in diverse cellular functions, including signal transduction, membrane trafficking, and infection. Many studies have reported relationships between insulin signaling rafts. Likewise, links O-GlcNAcylation also been described. However, the potential connection O-GlcNAc raft dynamics remains unexplored. Here we show that enzyme creates this modification, transferase (OGT),...
ERG family proteins (ERG, FLI1 and FEV) are a subfamily of ETS transcription factors with key roles in physiology development. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 regulates both alternative splicing pre-messenger RNAs. However, whether wild-type might regulate is unknown. Here, we show that associate spliceosomal components, found on nascent RNAs, induce when recruited onto reporter minigene. Transcriptomic analysis revealed large numbers spliced exons (ASEs) enriched...