A5001478916- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and biosynthesis
- Prostate Cancer Treatment and Research
- Nuts composition and effects
- Gut microbiota and health
- Bladder and Urothelial Cancer Treatments
- Tannin, Tannase and Anticancer Activities
- Diet and metabolism studies
- Cancer Research and Treatments
- Cholesterol and Lipid Metabolism
Université Laval
2016-2024
Hôtel-Dieu de Québec
2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction fecal alpha-diversity correlating with increase tumour burden two distinct groups of hormonotherapy naïve patients and three murine models. Fecal transplantation (FMT) from high volume is sufficient stimulate the growth mouse revealing existence microbiome-cancer crosstalk. Analysis microbial-related pathways mice...
Abstract Background High prostate eicosapentaenoic fatty acid (EPA) levels were associated with a significant reduction of upgrading to grade group (GG) ≥ 2 cancer in men under active surveillance. We aimed evaluate the effect MAG-EPA long-chain omega-3 dietary supplement on proliferation. Methods A phase II double-blind randomized placebo-controlled trial was conducted 130 diagnosed GG and undergoing radical prostatectomy between 2015–2017 (Clinicaltrials.gov: NCT02333435). Participants...
Background Several lines of evidence suggest effects dietary fat on prostate cancer (PCa) development and progression. Targeting omega (ω)‐3:ω6 fatty acids (FA) ratio could be beneficial against PCa by favorably modulating inflammation. Here, we studied the ω3‐ ω6‐enriched diets tumor growth inflammatory response in androgen‐deprived non‐deprived conditions. Methods Immune‐competent eugonadal castrated C57BL/6 mice were injected with TRAMP‐C2 cells daily fed or diet. FA cytokine profiles...
Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and levels assessed prostatic tissue, red blood cells (RBC), diet. We conducted a validation cross-sectional nested within phase II clinical trial. identified 157 men diagnosed with low-risk PCa...
The impact of omega (ω)-3 fatty acids on prostate cancer is controversial in epidemiological studies but experimental suggest a protective effect. However, little known about the mechanism action. Here, we studied effects purified acid molecules tumor progression using TRAMP-C2 syngeneic immunocompetent mouse model. Compared with ω-6 or ω-9-supplemented animals, observed that late-stage growth was reduced monoacylglyceride (MAG)-conjugated form eicosapentaenoic (EPA) supplementation, whereas...
<div>Abstract<p>The impact of omega (ω)-3 fatty acids on prostate cancer is controversial in epidemiological studies but experimental suggest a protective effect. However, little known about the mechanism action. Here, we studied effects purified acid molecules tumor progression using TRAMP-C2 syngeneic immunocompetent mouse model. Compared with ω-6 or ω-9–supplemented animals, observed that late-stage growth was reduced monoacylglyceride (MAG)-conjugated form eicosapentaenoic...
<p>S1. Chronic long-chain omega-3 (LCω3) treatment blocks prostate cancer cell growth. S2. Tables of differentially expressed genes in tumors MAG-EPA-supplemented mice. S3. Twenty men supplemented for 4-10 weeks with MAG-EPA or placebo before radical prostatectomy. S4. Stable expression the ω3 fatty acid desaturase 1 (FAT-1) from c. elegans, which convert ω6 into acids, hinders S5. Cytokine profiling mouse tumors.</p>
<p>S1. Chronic long-chain omega-3 (LCω3) treatment blocks prostate cancer cell growth. S2. Tables of differentially expressed genes in tumors MAG-EPA-supplemented mice. S3. Twenty men supplemented for 4-10 weeks with MAG-EPA or placebo before radical prostatectomy. S4. Stable expression the ω3 fatty acid desaturase 1 (FAT-1) from c. elegans, which convert ω6 into acids, hinders S5. Cytokine profiling mouse tumors.</p>
<div>Abstract<p>The impact of omega (ω)-3 fatty acids on prostate cancer is controversial in epidemiological studies but experimental suggest a protective effect. However, little known about the mechanism action. Here, we studied effects purified acid molecules tumor progression using TRAMP-C2 syngeneic immunocompetent mouse model. Compared with ω-6 or ω-9–supplemented animals, observed that late-stage growth was reduced monoacylglyceride (MAG)-conjugated form eicosapentaenoic...
You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VI1 Apr 2018PD42-09 EFFECTS OF OMEGA-3-RICH FISH OIL (MAG-EPA) ON PROSTATE CANCER: PRELIMINARY RESULTS A CLINICAL TRIAL Lisanne Beaudoin, Nikunj Gevariya, Karine Robitaille, Marie-Hélène Guertin, Jean-Francois Pelletier, Pierre Julien, and Vincent Fradet BeaudoinLisanne Beaudoin More articles by this author , GevariyaNikunj Gevariya RobitailleKarine Robitaille GuertinMarie-Hélène Guertin PelletierJean-Francois...
Abstract Introduction and Objective: Recently, gut microbiota emerged as an important factor for success of immunity-based cancer treatments. However, its steady-state interaction contribution to developing tumors is largely unexplored in non-intestinal cancers. Our objective was investigate the connection between prostate tumor independently therapies. Methods: Human fecal samples were obtained from men participating into a phase IIb double-blind randomized controlled trial testing 3g/day...