A5009379524- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Analytical Chemistry and Sensors
- Fatty Acid Research and Health
- Electrochemical sensors and biosensors
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Amino Acid Enzymes and Metabolism
- Biosensors and Analytical Detection
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Neuroscience and Neural Engineering
- Cancer Research and Treatments
- Photonic and Optical Devices
- Mechanical and Optical Resonators
- Regulation of Appetite and Obesity
- Laser Applications in Dentistry and Medicine
Université Laval
2018-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2020-2024
Centre hospitalier de l'Université Laval
2022
Centre of Excellence for Advanced Materials
2020
Montreal Heart Institute
2018
University of Ottawa
2012-2014
The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction fecal alpha-diversity correlating with increase tumour burden two distinct groups of hormonotherapy naïve patients and three murine models. Fecal transplantation (FMT) from high volume is sufficient stimulate the growth mouse revealing existence microbiome-cancer crosstalk. Analysis microbial-related pathways mice...
Human tumors display considerable diversity in their genetic makeup but share common physiologic attributes such as a hypoxic microenvironment that contribute to the malignant phenotype. Hypoxic cells switch from eukaryotic initiation factor 4E (eIF4E) eIF4E2 cap-dependent translation synthesize portion of proteins. Here, we show genetically distinct human cancer exploit eIF4E2-directed protein synthesis form cellular masses larger than approximately 0.15 mm, diffusion limit oxygen. Cancer...
Significance DNA methyltransferase 3a (DNMT3a) mediates the de novo methylation of to regulate gene expression and maintain cellular homeostasis. Mutations in DNMT3a primary tumors suggest that epigenetic program is modified during early tumorigenesis. We show a major consequence defects deregulation unscheduled activation EPAS1 (hypoxia-inducible factor 2α) facilitates growth viability under conditions low oxygen availability. This represents critical step tumorigenesis, because cancer...
Abstract Tumor‐associated macrophages (TAMs) support tumor progression within the microenvironment (TME). Many questions remain as to origin, development, and function of TAMs prostate TME. Evaluation in cancer (PCa) patients identified immunosuppressive TAM marker CD163 adjacent normal epithelium an independent predictor metastases or PCa death. Flow cytometry analyses frequently expressing both proinflammatory M1 (CCR7+) M2 (CD163+) markers. In vitro, we demonstrate cells similarly subvert...
Neurotransmitter analysis plays a pivotal role in diagnosing and managing neurodegenerative diseases, often characterized by disturbances neurotransmitter systems. However, prevailing methods for quantifying neurotransmitters involve invasive procedures or require bulky imaging equipment, therefore restricting accessibility posing potential risks to patients. The innovation of compact, vivo instruments neurotransmission holds the reshape disease management. This can facilitate non-invasive...
NADPH oxidase (NOX) enzymes are one of the major superoxide-generating systems in cells. NOX-generated superoxide has been suggested to promote insulin resistance liver. However, role NOX mediating metabolic dysfunction other target tissues remains unclear. Here, we show that NOX3 expression is induced differentiated 3T3-L1 adipocytes upon treatment with proinflammatory cytokines. Superoxide production increased concurrently protein cytokine-treated adipocytes, which was inhibited by...
Inducible nitric oxide (NO) synthase (NOS2) is a well-documented inflammatory mediator of insulin resistance in obesity. NOS2 expression induced both adipocytes and macrophages within adipose tissue during high-fat (HF)-induced obesity.Eight-week-old male mice with adipocyte selective deletion the Nos2 gene (Nos2AD-KO) their wildtype littermates (Nos2fl/fl) were subjected to chow or high-sucrose (HFHS) diet for 10 weeks followed by metabolic phenotyping determination brown (BAT)...
Liquid-phase exfoliation (LPE) of graphite is a promising strategy to prepare stabilized graphene inks for various applications. However, the stabilizing agents that have been used generally suffer from poor electrical properties, harming properties resulting composites once they are deposited on surface. In this study, we investigate use water-soluble, conjugated 2,6-azulene-based copolymer as agent aqueous dispersion. Due presence azulene within main chain, exhibits proton responsiveness...
The impact of omega (ω)-3 fatty acids on prostate cancer is controversial in epidemiological studies but experimental suggest a protective effect. However, little known about the mechanism action. Here, we studied effects purified acid molecules tumor progression using TRAMP-C2 syngeneic immunocompetent mouse model. Compared with ω-6 or ω-9-supplemented animals, observed that late-stage growth was reduced monoacylglyceride (MAG)-conjugated form eicosapentaenoic (EPA) supplementation, whereas...
The miniaturization of sensing systems often requires embedding an electronic subsystem for local or edge computing, to interface with the sensor pre-processing operations. part work presented in this paper is optoelectronic system that measures neurotransmitters concentration based on visible spectroscopy and currently implemented external processor a computer. This presents System Chip (SoC) design RISC-V required peripheral interfaces replace current system. new first simulated then...
Neurotransmitter sensing is currently a challenge in biomedical research, and optoelectronic may play an important role this field. In particular, miniature visible-light photo-spectrometers can be very useful for molecular detection. respect, work evaluates new type of spectrometer geometry based on the grism, or grating-prism, which combines optical grating prism. The system was first designed either transmission reflection geometry, then adapted to fit commercially available components so...
Human skin contains photolabile nitric oxide (NO) derivatives which decompose after UVA irradiation and release vasoactive NO. However, aside from blue light, barely nothing has been reported about the effects of red NIR wavelengths. We decided to investigate if photobiomodulation, using visible would increase NO in skin. A custom-built airtight sleeve envelopes forearm a subject was used measure emanating under photobiomodulation conditions quantified by chemiluminescence detection....
Neurotransmitter sensing in the brain is crucial for understanding of neuro-degenerative diseases. Most modern methods purpose rely on bulky instruments or are disruptive to neurotransmitter medium. In this work, we describe and evaluate design a novel, compact non-invasive instrument detection based colorimetric method. The includes grism-based spectrometer that measures wavelength shift gold nanoparticles functionalized with aptamers act as neurotransmitter-specific markers. It also...
The sensing of neurotransmitters is currently a difficult task for scientists in the field biomedical research. design new compact and accurate sensor would benefit greatly research being done on neurotransmitters. In this effect, optoelectronic sensors are ideal candidate as they non-invasive non-reactive to test sample. This work describes design, fabrication, calibration, tests type neurotransmitter using spectral analysis based Grism. optical was fitted with self calibrating algorithm...
In this work, we propose a semi-autonomous device to measure the absorbance spectrum of sample with high spectral resolution and intensity precision address previously mentioned issues. The proposed system includes integrated optical, microfluidic electronic modules. optical module is based on polychromator spectrophotometer using Grism diffractive component for resolution. layout also filter monochromator precision. controls all subsystems while communicating user interface data acquisition...
Neurotransmitter sensing is an importance component of biomedical research, and optoelectronic sensors play important role in it. In particular, visible-light photo-spectrometers can be very useful for molecular detection measurement. This work evaluates two optical design modes the conception a Czerny-Turner spectrometer. The system was designed at first using non-sequential mode then remade sequential mode. By comparing same made both modes, had shown superior optimization potential.
This work presents the design and implementation of a portable optofluidic system for biodetection based on ultrastable gold nanoparticles functionalized with dopamine-binding aptamer. The automatic sampling mixing fluidic integrated into spectrometer is configured to measure nanoparticles’ plasmon band position. novel molecule detection method has been previously tested using dopamine as target molecule. designed bathochromic shift an optical resolution 1 nm 50- <inline-formula...
Neurotransmitter sensing is essential in biomedical research to understand brain behavior, with Optical useful for passive measurements. For instance, visible-light spectrophotometry can be used detect and measure neurotransmitter concentrations liquid. An important part of the process prediction molecule concentration from measured data. This work describes an FPGA-based system a multi-sensor platform, using optical spectrometer simple regression predictor. The design required very few...
In this work, we propose a device to measure neurotransmitters in liquid solution using functionalized ultrastable gold nanoparticles multi-system architecture. The instrument is made of heterogeneous technological approach based on an optical, microfluidic and electronic systems synchronized together for the detection neurotransmitters. system used manipulate mix samples sensing vial. It was all designed at our laboratory be efficient, modular compact. optical layout spectrometer with grism...
Nitric oxide (NO) is synthesized from L‐arginine by NO synthase (NOS) enzymes. The expression of the inducible member NOS family, iNOS, markedly enhanced in adipose, skeletal muscle and liver tissues response to bacterial endotoxins (LPS), inflammatory cytokines, diet‐induced obesity. We have previously showed that mice lacking iNOS are protected insulin resistance induced high‐fat feeding; acute exposure LPS or lipid infusion, providing genetic evidence a key mediator these settings. It...