A5030430839- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
Harbin Medical University
2021-2024
Abstract Background IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, which a significant cause renal failure. At present, classification IgAN often limited to pathology, and its molecular mechanism has not been established. Therefore we aim identify subtypes at level explore heterogeneity in terms immune cell infiltration, functional level. Methods Two microarray datasets (GSE116626 GSE115857) were downloaded from GEO. Differential expression genes (DEGs) for...
Systemic lupus erythematosus (SLE) is a systemic and multifactorial autoimmune disease, its diverse clinical manifestations affect molecular diagnosis drug benefits. Our study was aimed at defining the SLE subtypes based on blood transcriptome data, analyzing functional patterns, elucidating benefits.Three data sets were used in this paper that collected from Gene Expression Omnibus (GEO) database, which contained two published of pediatric adult patients (GSE65391, GSE49454) public...
Systemic lupus erythematosus (SLE) is a complex disease involving many interactions at the molecular level, details of which remain unclear. Here, we demonstrated an analytical paradigm prioritizing genes and regulatory elements based on GWAS loci single-cell levels. Our initial step was to apply TWMR identify causal methylation sites in SLE. Based eQTL, LD mQTL, calculated correlation between these sites. Next, separately used gene expression DNAm as exposure variables outcome analyze...
Autoimmune diseases (ADs) are a broad range of in which the immune response to self-antigens causes damage or disorder tissues, and genetic susceptibility is regarded as key etiology ADs. Accumulating evidence has suggested that there certain commonalities among different However, theoretical research about similarity between ADs still limited. In this work, we first computed 26 based on three measurements: network (NetSim), functional (FunSim), semantic (SemSim), systematically identified...